8WIU

Bromodomain and Extra-terminal Domain (BET) BRD4

Summary for 8WIU

• Entry DOI: 10.2210/pdb8wiu/pdb
• Descriptor: Isoform C of Bromodomain-containing protein 4, 7-[5-[1-(cyclopropylmethyl)-3,5-dimethyl-pyrazol-4-yl]pyridin-3-yl]-1~{H}-imidazo[4,5-b]pyridine (3 entities in total)
• Functional Keywords: binds acetylated lysine residues, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15084.46

Authors

Cao, D.,Zhiyan, D.,Xiong, B. (deposition date: 2023-09-25, release date: 2024-01-03)

• Primary citation: Chen, X.,Wu, T.,Du, Z.,Kang, W.,Xu, R.,Meng, F.,Liu, C.,Chen, Y.,Bao, Q.,Shen, J.,You, Q.,Cao, D.,Jiang, Z.,Guo, X.; Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis.; Eur.J.Med.Chem., 265:116080-116080, 2023; PubMed: 38142510; DOI: 10.1016/j.ejmech.2023.116080

Experimental method

X-RAY DIFFRACTION (1.4 Å)