6Q76
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8ATZ
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![BU of 8atz by Molmil](/molmil-images/mine/8atz) | Crystal structure of PPAR gamma (PPARG) in complex with SA112 (compound 2). | 分子名称: | 2-[4-chloranyl-6-[[3-(2-phenylethoxy)phenyl]amino]pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma | 著者 | Chaikuad, A, Arifi, S, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-08-24 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145, 2023
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6CDB
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![BU of 6cdb by Molmil](/molmil-images/mine/6cdb) | Crystal Structure of V66L CzrA in the Zn(II)bound state | 分子名称: | ArsR family transcriptional regulator, CHLORIDE ION, SODIUM ION, ... | 著者 | Capdevila, D.A, Campanello, G, Gonzalez-Gutierrez, G, Giedroc, D.P. | 登録日 | 2018-02-08 | 公開日 | 2018-07-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System. J. Am. Chem. Soc., 140, 2018
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5UQY
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![BU of 5uqy by Molmil](/molmil-images/mine/5uqy) | Crystal structure of Marburg virus GP in complex with the human survivor antibody MR78 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP1, ... | 著者 | Hashiguchi, T, Fusco, M.L, Hastie, K.M, Bomholdt, Z.A, Lee, J.E, Flyak, A.I, Matsuoka, R, Kohda, D, Yanagi, Y, Hammel, M, Crowe, J.E, Saphire, E.O. | 登録日 | 2017-02-08 | 公開日 | 2017-03-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell, 160, 2015
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6HB2
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![BU of 6hb2 by Molmil](/molmil-images/mine/6hb2) | Structure of Hgh1, crystal form I, Selenomethionine derivative | 分子名称: | CHLORIDE ION, Protein HGH1 | 著者 | Moenkemeyer, L, Klaips, C.L, Balchin, D, Koerner, R, Hartl, F.U, Bracher, A. | 登録日 | 2018-08-09 | 公開日 | 2019-02-27 | 最終更新日 | 2019-04-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2. Mol.Cell, 74, 2019
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6FRA
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6CB0
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![BU of 6cb0 by Molmil](/molmil-images/mine/6cb0) | Crystal Structure of the FAK FERM domain | 分子名称: | Focal adhesion kinase 1 | 著者 | Dementiev, A, Marlowe, T. | 登録日 | 2018-02-01 | 公開日 | 2019-02-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site. BMC Mol Cell Biol, 20, 2019
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8AQ8
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![BU of 8aq8 by Molmil](/molmil-images/mine/8aq8) | FAD-dependent monooxygenase from Stenotrophomonas maltophilia | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Maly, M, Kolenko, P, Duskova, J, Skalova, T, Dohnalek, J. | 登録日 | 2022-08-11 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Tetracycline-modifying enzyme SmTetX from Stenotrophomonas maltophilia. Acta Crystallogr.,Sect.F, 79, 2023
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5URO
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![BU of 5uro by Molmil](/molmil-images/mine/5uro) | Structure of a soluble epoxide hydrolase identified in Trichoderma reesei | 分子名称: | 2,2'-oxydi(ethyn-1-ol), Predicted protein | 著者 | Wilson, C, de Oliveira, G, Chambergo, F, Dias, M.V.B. | 登録日 | 2017-02-11 | 公開日 | 2017-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | Structure of a soluble epoxide hydrolase identified in Trichoderma reesei. Biochim. Biophys. Acta, 1865, 2017
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6Q78
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8ATY
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![BU of 8aty by Molmil](/molmil-images/mine/8aty) | Crystal structure of PPAR gamma (PPARG) in complex with JP85 (compound 1). | 分子名称: | 2-[4-chloranyl-6-(5,6,7,8-tetrahydronaphthalen-1-ylamino)pyrimidin-2-yl]sulfanylethanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma | 著者 | Chaikuad, A, Pollinger, J, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2022-08-24 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPAR gamma Modulation. J.Am.Chem.Soc., 145, 2023
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6Q28
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8AVI
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![BU of 8avi by Molmil](/molmil-images/mine/8avi) | Crystal structure of IsdG from Bacillus cereus in complex with heme | 分子名称: | 1,3-PROPANDIOL, 1,4-BUTANEDIOL, Heme-degrading monooxygenase, ... | 著者 | Andersen, H.K, Hammerstad, M, Hersleth, H.-P. | 登録日 | 2022-08-26 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction. Antioxidants, 12, 2023
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5USV
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6Q7T
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![BU of 6q7t by Molmil](/molmil-images/mine/6q7t) | ERK2 mini-fragment binding | 分子名称: | 1,2-oxazol-3-amine, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-13 | 公開日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6HCE
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6GBO
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![BU of 6gbo by Molmil](/molmil-images/mine/6gbo) | Crystal Structure of the oligomerization domain of Vp35 from Ebola virus | 分子名称: | Polymerase cofactor VP35 | 著者 | Zinzula, L, Nagy, I, Orsini, M, Weyher-Stingl, E, Baumeister, W, Bracher, A. | 登録日 | 2018-04-16 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species. Structure, 27, 2019
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6CEV
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![BU of 6cev by Molmil](/molmil-images/mine/6cev) | MBD3 MBD in complex with methylated, non-palindromic CpG DNA: alternative interpretation of crystallographic data | 分子名称: | DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 3, ... | 著者 | Liu, K, Tempel, W, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-12 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.005 Å) | 主引用文献 | Structural analyses reveal that MBD3 is a methylated CG binder. Febs J., 286, 2019
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6Q3O
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![BU of 6q3o by Molmil](/molmil-images/mine/6q3o) | PROTEIN-AROMATIC FOLDAMER COMPLEX CRYSTAL STRUCTURE | 分子名称: | 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid, 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid, Carbonic anhydrase 2, ... | 著者 | Zeberko, C, Langlois d'Estaintot, B, Fischer, L, Granier, T, Kauffmann, B, Huc, I. | 登録日 | 2018-12-04 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | PROTEIN-AROMATIC FOLDAMER COMPLEX CRYSTAL STRUCTURE To Be Published
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6Q8C
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![BU of 6q8c by Molmil](/molmil-images/mine/6q8c) | Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine | 分子名称: | 1,2-ETHANEDIOL, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine, Leucine--tRNA ligase, ... | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | 登録日 | 2018-12-14 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173, 2019
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6FM9
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![BU of 6fm9 by Molmil](/molmil-images/mine/6fm9) | Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase | 著者 | Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2018-01-30 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell, 175, 2018
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6Q47
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6FMK
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![BU of 6fmk by Molmil](/molmil-images/mine/6fmk) | pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) | 分子名称: | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... | 著者 | Soares, P, Lucas, X, Ciulli, A. | 登録日 | 2018-01-31 | 公開日 | 2018-04-11 | 最終更新日 | 2018-06-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26, 2018
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8A9P
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![BU of 8a9p by Molmil](/molmil-images/mine/8a9p) | Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment | 分子名称: | (3-phenyl-1,2,4-oxadiazol-5-yl)methanamine, BROMIDE ION, CHLORIDE ION, ... | 著者 | Snee, M, Katariya, M, Levy, C, Leys, D. | 登録日 | 2022-06-29 | 公開日 | 2023-07-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment To Be Published
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6CF3
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![BU of 6cf3 by Molmil](/molmil-images/mine/6cf3) | Ethylene forming enzyme Y306A variant in complex with manganese and 2-oxoglutarate | 分子名称: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ... | 著者 | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | 登録日 | 2018-02-13 | 公開日 | 2019-02-13 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme. Biochemistry, 2024
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