PDB: 98041 件ウェブページステータス検索Chemie searchBIRD

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7NK3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-128 分子名称: 14-3-3 protein sigma, 2-(4-methylphenyl)sulfonyl-3,4-dihydro-1~{H}-isoquinoline, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-17 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
8PPO	First Intermediate Amyloid (FIA) - Tau 分子名称: Microtubule-associated protein tau 著者 Lovestam, S, Scheres, S.H.W, Goedert, M, Li, D. 登録日 2023-07-07 公開日 2023-08-02 最終更新日 2024-01-24 実験手法 ELECTRON MICROSCOPY (2 Å) 主引用文献 Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
7NJ9	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-133 分子名称: 14-3-3 protein sigma, 4-(3,4-dihydro-2~{H}-quinolin-1-ylsulfonyl)benzaldehyde, DI(HYDROXYETHYL)ETHER, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-16 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NIF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-011 分子名称: 1-(4-methylphenyl)imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-12 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
4SDH	HIGH RESOLUTION CRYSTALLOGRAPHIC ANALYSIS OF A COOPERATIVE DIMERIC HEMOGLOBIN 分子名称: HEMOGLOBIN I (DEOXY), PROTOPORPHYRIN IX CONTAINING FE 著者 Royerjunior, W.E. 登録日 1993-06-23 公開日 1993-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 High-resolution crystallographic analysis of a co-operative dimeric hemoglobin. J.Mol.Biol., 235, 1994
7NJB	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-132 分子名称: 14-3-3 protein sigma, 4-piperidin-1-ylsulfonylbenzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-16 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
1YCK	Crystal structure of human peptidoglycan recognition protein (PGRP-S) 分子名称: Peptidoglycan recognition protein 著者 Guan, R, Wang, Q, Sundberg, E.J, Mariuzza, R.A. 登録日 2004-12-22 公開日 2005-03-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. J.Mol.Biol., 347, 2005
7NJ6	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1005 分子名称: 14-3-3 protein sigma, 4-[4-(trifluoromethyl)imidazol-1-yl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-16 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7NJ8	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1007 分子名称: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-16 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
5DVA	Fragments bound to the OXA-48 beta-lactamase: Compound 1 分子名称: 3-(pyridin-4-yl)benzoic acid, Beta-lactamase, CHLORIDE ION 著者 Lund, B.A, Christopeit, T, Leiros, H.-K.S. 登録日 2015-09-21 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.50003886 Å) 主引用文献 Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening. J.Med.Chem., 59, 2016
7NIG	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1008 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-12 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7NJA	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1006 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-16 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
4RML	Crystal structure of the Olfactomedin domain of latrophilin 3 in C2221 crystal form 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Latrophilin-3, MAGNESIUM ION 著者 Ranaivoson, F.M, Liu, Q, Martini, F, Bergami, F, Von daake, S, Li, S, Demeler, B, Hendrickson, W.A, Comoletti, D. 登録日 2014-10-21 公開日 2015-08-19 最終更新日 2015-10-07 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development. Structure, 23, 2015
5DYU	Crystal Structure of BAZ2B bromodomain in complex with fragment F39 分子名称: 1H-imidazol-5-ylmethanol, Bromodomain adjacent to zinc finger domain protein 2B 著者 Lolli, G, Caflisch, A. 登録日 2015-09-25 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. Acs Chem.Biol., 11, 2016
5DZ6	Acyl transferase from Bacillaene PKS 分子名称: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... 著者 Till, M, Race, P.R. 登録日 2015-09-25 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Architectural hierarchy of trans-acting enoyl reductases from polyunsaturated fatty acid and trans-acyltransferase polyketide synthases To Be Published
4TLJ	Ultra-high resolution crystal structure of caprine Beta-lactoglobulin 分子名称: 1,4-BUTANEDIOL, Beta-lactoglobulin 著者 Crowther, J.M, Jameson, G.B, Suzuki, H, Dobson, R.C.J. 登録日 2014-05-30 公開日 2014-06-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.17 Å) 主引用文献 Ultra-high resolution crystal structure of recombinant caprine beta-lactoglobulin. Febs Lett., 588, 2014
5E7B	Structure of a nanobody (vHH) from camel against phage Tuc2009 RBP (BppL, ORF53) 分子名称: nanobody nano-L06 著者 Legrand, P, Collins, B, Blangy, S, Murphy, J, Spinelli, S, Gutierrez, C, Richet, N, Kellenberger, C, Desmyter, A, Mahony, J, van Sinderen, D, Cambillau, C. 登録日 2015-10-12 公開日 2015-12-30 最終更新日 2016-05-04 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules. Mbio, 7, 2016
4HAX	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4HB0	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 分子名称: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
6RWH	Fragment AZ-007 binding at a primary and secondary binding site of the the p53pT387/14-3-3 sigma complex 分子名称: 14-3-3 protein sigma, 5-(1~{H}-imidazol-5-yl)-4-phenyl-thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
1HIM	STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION 分子名称: IGG2A-KAPPA 17/9 FAB (HEAVY CHAIN), IGG2A-KAPPA 17/9 FAB (LIGHT CHAIN), INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 100-108) 著者 Schulze-Gahmen, U, Wilson, I.A. 登録日 1992-07-08 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural evidence for induced fit as a mechanism for antibody-antigen recognition. Science, 255, 1992
7LPA	Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius 分子名称: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... 著者 Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. 登録日 2021-02-11 公開日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
7LPE	Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 分子名称: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... 著者 Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. 登録日 2021-02-11 公開日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3.72 Å) 主引用文献 Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
1HIN	STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION 分子名称: IGG2A-KAPPA 17/9 FAB (HEAVY CHAIN), IGG2A-KAPPA 17/9 FAB (LIGHT CHAIN), INFLUENZA HEMAGGLUTININ HA1 (STRAIN X47) (RESIDUES 100-107) 著者 Rini, J.M, Wilson, I.A. 登録日 1992-07-08 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural evidence for induced fit as a mechanism for antibody-antigen recognition. Science, 255, 1992
4QRP	Crystal Structure of HLA B*0801 in complex with HSKKKCDEL and DD31 TCR 分子名称: Beta-2-microglobulin, DD31 TCR alpha chain, DD31 TCR beta chain, ... 著者 Gras, S, Berry, R, Lucet, I.S, Rossjohn, J. 登録日 2014-07-02 公開日 2014-11-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant. J.Immunol., 193, 2014

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