PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

---

7O7C	Crystal structure of rsEGFP2 mutant V151A in the non-fluorescent off-state determined by synchrotron radiation at 100K 分子名称: Green fluorescent protein, SULFATE ION 著者 Woodhouse, J, Adam, V, Hadjidemetriou, K, Colletier, J.-P, Weik, M. 登録日 2021-04-13 公開日 2022-07-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Rational Control of Off-State Heterogeneity in a Photoswitchable Fluorescent Protein Provides Switching Contrast Enhancement. Chemphyschem, 23, 2022
8ZHI	SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (6.05 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
8ZHJ	SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C1 symmetry) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (8.45 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
8ZHK	SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
7NY9	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 38 分子名称: 3-[2,6-bis(oxidanylidene)-4-(trifluoromethyl)-5~{H}-pyrimidin-1-yl]-~{N}-methyl-2-pyridin-2-yl-imidazo[1,2-a]pyridine-7-carboxamide, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-22 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
8ZHL	SARS-CoV-2 spike trimer (6P) in complex with two H18 and two R1-32 Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.96 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
8ZHM	SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
8ZHN	SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs (one RBD rotated) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... 著者 Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. 登録日 2024-05-11 公開日 2024-08-21 実験手法 ELECTRON MICROSCOPY (4.12 Å) 主引用文献 Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
7OA9	Crystal structure of Human Menin in complex with Fragment 21 分子名称: (~{E})-2-cyano-3-(4-hydroxyphenyl)-~{N}-(2-morpholin-4-ylethyl)prop-2-enamide, 1,2-ETHANEDIOL, GLYCEROL, ... 著者 Groves, M.R, Gao, K. 登録日 2021-04-19 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Crystal structure of Human Menin in complex with Fragment 21 To Be Published
7OAS	Structural basis for targeted p97 remodeling by ASPL as prerequisite for p97 trimethylation by METTL21D 分子名称: 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, S-adenosyl-L-methionine-dependent methyltransferases superfamily protein 著者 Petrovic, S, Heinemann, U, Roske, Y. 登録日 2021-04-20 公開日 2022-08-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.819 Å) 主引用文献 Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc.Natl.Acad.Sci.USA, 120, 2023
7NXO	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 24(5-F) 分子名称: 4-[2,4-bis(oxidanylidene)-6-(phenylsulfonyl)-1H-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-19 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
7OAT	Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Petrovic, S, Heinemann, U, Roske, Y. 登録日 2021-04-20 公開日 2022-08-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc.Natl.Acad.Sci.USA, 120, 2023
7NWA	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND COMPOUND A 分子名称: 2-[[4-chloranyl-2,6-bis(fluoranyl)phenyl]methylamino]-7-oxidanylidene-5-propyl-4H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-16 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
7NWB	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 1 分子名称: 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-16 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
7NYA	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR BAY-069 (COMPOUND 36) 分子名称: 3-[4-chloranyl-3-(2-methylphenoxy)naphthalen-1-yl]-6-(trifluoromethyl)-5~{H}-pyrimidine-2,4-dione, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-22 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
7NWM	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 12 分子名称: 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-5-methoxy-2-(2-methylphenoxy)benzenecarbonitrile, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-17 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
6AZP	A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Ramyar, K.X, Geisbrecht, B.V. 登録日 2017-09-11 公開日 2017-12-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.291 Å) 主引用文献 A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor (SPIN). J. Biol. Chem., 293, 2018
7NWC	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 2 分子名称: 3-(5-chloranyl-2,4-dimethoxy-phenyl)-6-(trifluoromethyl)-1H-pyrimidine-2,4-dione, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-16 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
7NXN	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 21(5-F) 分子名称: 4-[6-[bis(fluoranyl)-phenyl-methyl]-2,4-bis(oxidanylidene)-1~{H}-pyrimidin-3-yl]-5-fluoranyl-2-(2-methylphenoxy)benzenecarbonitrile, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-19 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
6P2D	Structure of mouse ketohexokinase-C in complex with fructose and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Ketohexokinase, NITRATE ION, ... 著者 Gasper, W.C, Allen, K.N, Tolan, D.R. 登録日 2019-05-21 公開日 2020-06-03 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Michaelis-like complex of mouse ketohexokinase isoform C ACTA CRYSTALLOGR.,SECT.D, 2024
7NY2	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 35 分子名称: 4-[2,4-bis(oxidanylidene)-6-(trifluoromethyl)-1H-pyrimidin-3-yl]-2-(2-methylphenoxy)naphthalene-1-carbonitrile, Branched-chain-amino-acid aminotransferase, cytosolic, ... 著者 Hillig, R.C. 登録日 2021-03-19 公開日 2022-11-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J.Med.Chem., 65, 2022
7O6U	Crystal structure of the VIN3 VEL polymerising domain (R554A R556D mutant) 分子名称: Protein VERNALIZATION INSENSITIVE 3 著者 Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M. 登録日 2021-04-12 公開日 2022-11-09 最終更新日 2022-11-23 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control. Cell Rep, 41, 2022
7O6T	Crystal structure of the polymerising VEL domain of VIN3 (R556D I575D mutant) 分子名称: MAGNESIUM ION, Protein VERNALIZATION INSENSITIVE 3 著者 Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M. 登録日 2021-04-12 公開日 2022-11-09 最終更新日 2022-11-23 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control. Cell Rep, 41, 2022
7O4D	QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline 分子名称: 8-methyl-2-(4-methyl-3-piperazin-1-ylsulfonyl-phenyl)imidazo[1,2-a]pyridine, FLAVIN-ADENINE DINUCLEOTIDE, Ribosyldihydronicotinamide dehydrogenase [quinone], ... 著者 Gould, N.L, Scherer, G.R, Carvalh, S, Shurrush, K, Edry, E, Elkobi, A, David, O, Dym, O, Albeck, S, Peleg, Y, Germain, N, Babaev, I, Sharir, H, Lefker, B, Subramanyam, C, Barr, H, Rosenblum, K. 登録日 2021-04-06 公開日 2022-08-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.249 Å) 主引用文献 Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice. J.Clin.Invest., 133, 2023
7O6V	Crystal structure of the VEL1 VEL polymerising domain (R643A K645D I664D mutant) 分子名称: VIN3-like protein 2 著者 Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M. 登録日 2021-04-12 公開日 2022-11-09 最終更新日 2022-11-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control. Cell Rep, 41, 2022

<806807808809810811812813814815816817818819820821>