PDB: 30867 件ウェブページステータス検索Chemie searchBIRD

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6Q49	CDK2 in complex with FragLite6 分子名称: 4-bromanyl-1~{H}-pyridin-2-one, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
8SMH	Chimeric ETS-domain of murine PU.1 harboring the corresponding beta-strand 3 (S3) residues from murine Ets-1 in complex with d(AATAAGCGGAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2023-04-26 公開日 2023-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. Structure, 32, 2024
6CQG	YycF Effector Domain Structure without DNA bound 分子名称: DNA-binding response regulator, ZINC ION 著者 Riboldi-Tunnicliffe, A, Gabrielsen, M, Williamson, R.M, Panjikar, S. 登録日 2018-03-15 公開日 2019-06-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.932 Å) 主引用文献 YycF Effector Domain Structure without DNA bound To Be Published
6YS6	Arabidopsis aspartate transcarbamoylase complex with PALA 分子名称: GLYCEROL, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, PYRB, ... 著者 Ramon Maiques, S, Del Cano Ochoa, F, Bellin, L, Mohlmann, T. 登録日 2020-04-21 公開日 2021-03-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase. Nat Commun, 12, 2021
8AU6	Structure of Corynebacterium glutamicum Cg1604, a cell division regulator 分子名称: CALCIUM ION, Regulatory protein Cg1604 著者 Gaday, Q, Wehenkel, A.M, Alzari, P.M. 登録日 2022-08-25 公開日 2023-01-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales. Proc.Natl.Acad.Sci.USA, 119, 2022
8SP1	Chimeric ETS-domain of murine PU.1 harboring the corresponding beta-strand 3 (S3) residues from murine Ets-1 in complex with d(AATAAGCGIAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2023-05-01 公開日 2023-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. Structure, 32, 2024
5VXS	Crystal Structure Analysis of human CLYBL in apo form 分子名称: CITRIC ACID, Citrate lyase subunit beta-like protein, mitochondrial 著者 Shen, H. 登録日 2017-05-24 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.954 Å) 主引用文献 The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12. Cell, 171, 2017
8STS	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) varient in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (JLJ636), a non-nucleoside inhibitor 分子名称: 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... 著者 Hollander, K, Jorgensen, W.L, Anderson, K.S. 登録日 2023-05-11 公開日 2023-11-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 分子名称: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Ottmann, C. 登録日 2021-12-14 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
6CQN	Crystal structure of F5 TCR -DR11-RQ13 peptide complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, F5 alpha chain, ... 著者 Farenc, C, Gras, S, Rossjohn, J. 登録日 2018-03-15 公開日 2018-06-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 CD4+T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 3, 2018
6Y1R	Nb22-LBT 分子名称: Nb22-LBT, SULFATE ION, TERBIUM(III) ION 著者 Pompidor, G, Zimmermann, S, Loew, C, Schneider, T. 登録日 2020-02-13 公開日 2021-02-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Engineered nanobodies with a lanthanide binding motif for crystallographic phasing To Be Published
6Q4G	CDK2 in complex with FragLite37 分子名称: 2-[3-(2-azanyl-9~{H}-purin-6-yl)phenyl]ethanoic acid, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (0.98 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
7QRG	Structure of the post-fusion complex between precursor membrane ectodomain (prM) and envelope ectodomain protein (E) from tick-borne encephalitis virus 分子名称: Envelope protein E, GLYCEROL, Genome polyprotein 著者 Vaney, M.C, Rouvinski, A, Rey, F.A. 登録日 2022-01-11 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery. Nat Commun, 13, 2022
7KHM	Crystal structure of hDHHS20 bound to palmitoyl CoA 分子名称: Isoform 4 of Palmitoyltransferase ZDHHC20, PHOSPHATE ION, Palmitoyl-CoA, ... 著者 Lee, C.-J, Banerjee, A. 登録日 2020-10-21 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase. Proc.Natl.Acad.Sci.USA, 119, 2022
8SME	Structure of SPO1 phage Tad2 in apo state 分子名称: Gp34.65 著者 Lu, A, Yirmiya, E, Leavitt, A, Avraham, C, Osterman, I, Garb, J, Antine, S.P, Mooney, S.E, Hobbs, S.J, Amitai, G, Sorek, R, Kranzusch, P.J. 登録日 2023-04-26 公開日 2023-11-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Phages overcome bacterial immunity via diverse anti-defence proteins. Nature, 625, 2024
6CR0	1.55 A resolution structure of (S)-6-hydroxynicotine oxidase from Shinella HZN7 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, (S)-6-hydroxynicotine oxidase, ACETATE ION, ... 著者 Deay III, D, Lovell, S, Battaile, K.P, Petillo, P, Richter, M. 登録日 2018-03-16 公開日 2018-03-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.548 Å) 主引用文献 Improving the kinetic parameters of nicotine oxidizing enzymes by homologous structure comparison and rational design Arch.Biochem.Biophys., 2022
6Y21	Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-Cystathionine 分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase 著者 Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. 登録日 2020-02-14 公開日 2021-02-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Cystathionine Beta-synthase from Toxoplasma gondii with PLP-Cystathionine To Be Published
7QRE	Structure of the hetero-tetramer complex between precursor membrane protein fragment (pr) and envelope protein (E) from tick-borne encephalitis virus 分子名称: ACETATE ION, Envelope protein E, Genome polyprotein, ... 著者 Vaney, M.C, Dellarole, M, Rey, F.A. 登録日 2022-01-11 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery. Nat Commun, 13, 2022
6PU5	MicroED structure of proteinase K recorded on CetaD 分子名称: CALCIUM ION, Proteinase K 著者 Hattne, J, Martynowycz, M.W, Penzcek, P.A, Gonen, T. 登録日 2019-07-17 公開日 2019-08-28 最終更新日 2023-10-11 実験手法 ELECTRON CRYSTALLOGRAPHY (2.7 Å) 主引用文献 MicroED with the Falcon III direct electron detector. Iucrj, 6, 2019
5FA5	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ... 著者 Sprague, E.R, McNamara, J.T. 登録日 2015-12-10 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351, 2016
7QF0	Crystal structure of the SARS-CoV-2 RBD in complex with the human antibody CV2.2325 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CV2.2325 heavy chain, ... 著者 Fernandez, I, Pederzoli, R, Rey, F.A. 登録日 2021-12-03 公開日 2022-05-18 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2. J.Exp.Med., 219, 2022
8STV	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor 分子名称: 1,2-ETHANEDIOL, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, MAGNESIUM ION, ... 著者 Hollander, K, Jorgensen, W.L, Anderson, K.S. 登録日 2023-05-11 公開日 2023-11-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
6Q4O	Fusidic acid bound AcrB_I27A 分子名称: (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPIN, DECANE, ... 著者 Tam, H.K, Pos, K.M. 登録日 2018-12-06 公開日 2019-11-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB. J.Mol.Biol., 432, 2020
6HB0	Crystal structure of MSMEG_1712 from Mycobacterium smegmatis 分子名称: ABC transporter periplasmic-binding protein YtfQ, ZINC ION 著者 Li, M, Mueller, C, Einsle, O, Jessen-Trefzer, C. 登録日 2018-08-09 公開日 2019-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol. Cell Chem Biol, 26, 2019
7KP6	Structure of Ack1 kinase in complex with a selective inhibitor 分子名称: 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine, Activated CDC42 kinase 1, CHLORIDE ION 著者 Thakur, M.K, Miller, W.T, Mahajan, N, Seeliger, M.A. 登録日 2020-11-10 公開日 2022-02-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nat Commun, 13, 2022

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