8J00
| Human KCNQ2-CaM in complex with CBD | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8IZY
| Human KCNQ2-CaM in complex with HN37 | 分子名称: | Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8IOB
| Herg1a-herg1b closed state 1 | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | 著者 | Zhang, M.F. | 登録日 | 2023-03-10 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of Herg1a-herg1b closed state 1 To Be Published
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8IO5
| Herg1a-herg1b closed state 2 | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | 著者 | Zhang, M.F. | 登録日 | 2023-03-10 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of Herg1a-herg1b open state To Be Published
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8IO4
| Herg1a-herg1b open state | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | 著者 | Zhang, M.F. | 登録日 | 2023-03-10 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of Herg1a-herg1b open state To Be Published
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8IO3
| Cryo-EM structure of human HCN3 channel with cilobradine | 分子名称: | 3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | 著者 | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | 登録日 | 2023-03-10 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM structure of human HCN3 channel with cilobradine To Be Published
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8INZ
| Cryo-EM structure of human HCN3 channel in apo state | 分子名称: | 4-[[(2~{S},4~{a}~{R},6~{S},8~{a}~{S})-6-[(4~{S},5~{R})-4-[(2~{S})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | 著者 | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | 登録日 | 2023-03-10 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Cryo-EM structure of human HCN3 channel and its regulation by cAMP. J.Biol.Chem., 300, 2024
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8IJK
| human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 | 分子名称: | Calmodulin-1, N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Ma, D, Guo, J. | 登録日 | 2023-02-27 | 公開日 | 2024-01-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol., 20, 2024
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8I5Y
| Structure of human Nav1.7 in complex with vixotrigine | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5X
| Structure of human Nav1.7 in complex with Vinpocetine | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5G
| Structure of human Nav1.7 in complex with PF-05089771 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-25 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8I5B
| Structure of human Nav1.7 in complex with bupivacaine | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-24 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8HMB
| Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with benidipine (BEN) | 分子名称: | (3R)-1-benzylpiperidin-3-yl methyl (2R,3R,4R,5R,6S)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-12-02 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HMA
| Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-12-02 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HLP
| Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-11-30 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HK7
| Structure of PKD2-F604P (Polycystin-2, TRPP2) with ML-SA1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, CALCIUM ION, ... | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | 登録日 | 2022-11-25 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands. Proc.Natl.Acad.Sci.USA, 121, 2024
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8HA2
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8HA1
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8H9Y
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8H9X
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8H9W
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8H9O
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8GZ2
| Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin | 分子名称: | (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 8 subunit alpha, ... | 著者 | Li, Y, Jiang, D. | 登録日 | 2022-09-24 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
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8GZ1
| Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Sodium channel protein type 8 subunit alpha, ... | 著者 | Li, Y, Jiang, D. | 登録日 | 2022-09-24 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
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8GVX
| Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2 | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Won, J, Jeong, H, Lee, H.H. | 登録日 | 2022-09-16 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Molecular architecture of the G alpha i -bound TRPC5 ion channel. Nat Commun, 14, 2023
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