PDB: 284 件ウェブページステータス検索Chemie searchBIRD

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2WGE	Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGG	Crystal Structure of Mycobacterium tuberculosis C171Q KasA variant with bound TLM 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, NONAETHYLENE GLYCOL, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2VB7	beta-ketoacyl-ACP synthase I (KAS) from E. coli, apo structure after soak in PEG solution 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1 著者 Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M. 登録日 2007-09-06 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallogr.,Sect.D, 63, 2007
2VZ8	Crystal Structure of Mammalian Fatty Acid Synthase 分子名称: FATTY ACID SYNTHASE 著者 Maier, T, Leibundgut, M, Ban, N. 登録日 2008-07-31 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.219 Å) 主引用文献 The Crystal Structure of a Mammalian Fatty Acid Synthase. Science, 321, 2008
2VZ9	Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP 分子名称: FATTY ACID SYNTHASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Maier, T, Leibundgut, M, Ban, N. 登録日 2008-07-31 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The Crystal Structure of a Mammalian Fatty Acid Synthase. Science, 321, 2008
2WGF	Crystal structure of Mycobacterium tuberculosis C171Q KasA variant 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... 著者 Luckner, S.R, Kisker, C. 登録日 2009-04-17 公開日 2009-07-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2VB8	beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, CHLORIDE ION, THIOLACTOMYCIN 著者 Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M. 登録日 2007-09-06 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallogr.,Sect.D, 63, 2007
2UV8	Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom resolution 分子名称: FATTY ACID SYNTHASE SUBUNIT ALPHA (FAS2), FATTY ACID SYNTHASE SUBUNIT BETA (FAS1), FLAVIN MONONUCLEOTIDE 著者 Leibundgut, M, Jenni, S, Frick, C, Ban, N. 登録日 2007-03-09 公開日 2007-04-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase Science, 316, 2007
2VBA	beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound amino- thiazole inhibitor 分子名称: 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1 著者 Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M. 登録日 2007-09-06 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallogr.,Sect.D, 63, 2007
2BYY	E.coli KAS I H298E Mutation 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BUH	E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I, 120 K 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION 著者 Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-06-13 公開日 2005-06-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2C9H	Structure of mitochondrial beta-ketoacyl synthase 分子名称: MITOCHONDRIAL BETA-KETOACYL SYNTHASE, NICKEL (II) ION 著者 Bunkoczi, G, Wu, X, Smee, C, Gileadi, O, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, von Delft, F, Oppermann, U. 登録日 2005-12-12 公開日 2005-12-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of Mitochondrial Beta-Ketoacyl Synthase To be Published
2BYX	KAS I LYS328ALA Mutant in complex with fatty acid 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BYW	Structure of Escherichia coli beta-ketoacyl (acyl carrier protein) synthase I LYS328ALA mutant 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-09 公開日 2005-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BZ4	structure of E.coli KAS I H298Q mutant 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, SULFATE ION 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-10 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BZ3	Structure of E.coli KAS I H298E mutant in complex with C12 fatty acid 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID, ... 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-10 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BUI	E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I IN COMPLEX WITH OCTANOIC ACID, 120K 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, OCTANOIC ACID (CAPRYLIC ACID) 著者 Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-06-13 公開日 2005-06-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BYZ	Structure of E.coli KAS I H298Q mutant in complex with C12 fatty acid 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID 著者 Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. 登録日 2005-08-09 公開日 2006-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2CF2	Architecture of mammalian fatty acid synthase 分子名称: FATTY ACID SYNTHASE, DH DOMAIN, ER DOMAIN, ... 著者 Maier, T, Jenni, S, Ban, N. 登録日 2006-02-14 公開日 2006-03-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 Architecture of Mammalian Fatty Acid Synthase at 4.5 A Resolution. Science, 311, 2006
2AQ7	Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli 分子名称: (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I 著者 Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. 登録日 2005-08-17 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
2ALM	Crystal structure analysis of a mutant beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae 分子名称: 3-oxoacyl-(acyl-carrier-protein) synthase II, MAGNESIUM ION 著者 Zhang, Y.M, Hurlbert, J, White, S.W, Rock, C.O. 登録日 2005-08-07 公開日 2005-08-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae. J.Biol.Chem., 281, 2006
2AQB	Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli 分子名称: (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I 著者 Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. 登録日 2005-08-17 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
8CG5	The ACP crosslinked to the KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT) 分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide 著者 Munoz-Hernandez, H, Tittes, Y.U, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 CryoEM structure of ACP crosslinked to KS of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (SAT-KS:ACP-MAT) at 2.7 Angstroms resolution To Be Published
8CG6	The ACP crosslinked to the SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) 分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide 著者 Munoz-Hernandez, H, Tittes, Y.U, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 CryoEM structure of ACP crosslinked to SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) at 3.4 Angstroms resolution To Be Published
8CG4	The organise full-length structure of the fungal non-reducing polyketide synthase (NR-PKS) PksA 分子名称: Norsolorinic acid synthase 著者 Munoz-Hernandez, H, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 CryoEM structure of the Aspergilus sp. fungal non-reducing polyketide synthase (NR-PKS) PksA at 2.6 Angstroms resolution To Be Published

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