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2VBA

beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound amino- thiazole inhibitor

Summary for 2VBA
Entry DOI10.2210/pdb2vba/pdb
Related1DD8 1EK4 1F91 1FJ4 1FJ8 1G5X 1H4F 2AQ7 2AQB 2BUH 2BUI 2BYW 2BYX 2BYY 2BYZ 2BZ3 2BZ4 2VB7 2VB8 2VB9
Descriptor3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE (3 entities in total)
Functional Keywordscytoplasm, antibiotic, transferase, amino-thiazole, acyltransferase, lipid synthesis, fatty acid synthesis, fatty acid biosynthesis
Biological sourceESCHERICHIA COLI
Total number of polymer chains4
Total formula weight170857.11
Authors
Pappenberger, G.,Schulz-Gasch, T.,Bailly, J.,Hennig, M. (deposition date: 2007-09-06, release date: 2007-12-25, Last modification date: 2023-12-13)
Primary citationPappenberger, G.,Schulz-Gasch, T.,Kusznir, E.,Mueller, F.,Hennig, M.
Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis.
Acta Crystallogr.,Sect.D, 63:1208-, 2007
Cited by
PubMed: 18084068
DOI: 10.1107/S0907444907049852
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.36 Å)
Structure validation

217705

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