PDB: 663 件ウェブページステータス検索Chemie searchBIRD

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2XXT	Crystal structure of the GluK2 (GluR6) wild-type LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXX	Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate (P21 21 21) 分子名称: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXW	Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate 分子名称: CHLORIDE ION, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXU	Crystal structure of the GluK2 (GluR6) M770K LBD dimer in complex with glutamate 分子名称: CHLORIDE ION, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXV	Crystal structure of the GluK2 (GluR6) M770K LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXY	Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
3PMV	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMW	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: DIMETHYL SULFOXIDE, GLUTAMIC ACID, GLYCEROL, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2023-05-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMX	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... 著者 Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3QXM	Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A 分子名称: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, Glutamate receptor ionotropic, kainate 2 著者 Unno, M, Sasaki, M, Ikeda-Saito, M. 登録日 2011-03-02 公開日 2011-10-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide 著者 Kallen, J. 登録日 2011-03-23 公開日 2011-05-18 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator 分子名称: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... 著者 Timm, D.E. 登録日 2011-04-22 公開日 2011-05-25 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3RT6	Fluorowillardiine bound to the ligand binding domain of GluA3 分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.836 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RT8	Chlorowillardiine bound to the ligand binding domain of GluA3 分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 3, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.426 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-03 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RTW	Nitrowillardiine bound to the ligand binding domain of GluA2 分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-05-04 公開日 2011-05-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3S2V	Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution 分子名称: (S)-1-(2'-AMINO-2'-CARBOXYETHYL)-3-[(2-CARBOXYTHIEN-3-YL)METHYL]THIENO[3,4-D]PYRIMIDIN-2,4-DIONE, CHLORIDE ION, GLYCEROL, ... 著者 Venskutonyte, R, Frydenvang, K, Kastrup, J.S. 登録日 2011-05-17 公開日 2011-06-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. J.Med.Chem., 54, 2011
3S9E	Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate 分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... 著者 Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2011-06-01 公開日 2011-09-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J.Struct.Biol., 176, 2011
3T96	Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.872 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T9H	Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.015 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T93	Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-02 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.907 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T9V	CNQX bound to a reduced double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.975 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T9X	Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.823 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T9U	CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2011-08-03 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011

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