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2DLZ
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Solution structure of the SH2 domain of human protein vav-2
分子名称: Protein vav-2
著者Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-04-20
公開日2007-04-03
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain of human protein vav-2
To be Published
2DLY
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BU of 2dly by Molmil
Solution structure of the SH2 domain of murine Fyn-related kinase
分子名称: Fyn-related kinase
著者Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-04-20
公開日2006-10-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain of murine Fyn-related kinase
To be Published
2GSB
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BU of 2gsb by Molmil
Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1
分子名称: Ras GTPase-activating protein 1
著者Kurosaki, C, Suetake, T, Yoshida, M, Hayashi, F, Yokoyma, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-04-26
公開日2007-05-01
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1
To be Published
2H46
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BU of 2h46 by Molmil
Native domain-swapped dimer crystal structure of the Grb2 SH2 domain
分子名称: GLYCEROL, Growth Receptor Binding Protein 2
著者Benfield, A.P, Martin, S.F, Whiddon, B.B.
登録日2006-05-23
公開日2006-06-06
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2H5K
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BU of 2h5k by Molmil
Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2
分子名称: CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand
著者Benfield, A.P, Whiddon, B.B, Martin, S.F.
登録日2006-05-26
公開日2006-08-15
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
2IUG
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BU of 2iug by Molmil
Crystal structure of the PI3-kinase p85 N-terminal SH2 domain
分子名称: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
著者Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
登録日2006-06-03
公開日2006-06-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUI
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide
分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta
著者Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
登録日2006-06-03
公開日2006-06-06
最終更新日2021-04-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2IUH
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Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide
分子名称: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT
著者Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C.
登録日2006-06-03
公開日2006-06-06
最終更新日2021-04-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
2H8H
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Src kinase in complex with a quinazoline inhibitor
分子名称: N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE, Proto-oncogene tyrosine-protein kinase Src
著者Otterbein, L.R, Norman, R, Pauptit, R.A, Rowsell, S, Breed, J.
登録日2006-06-07
公開日2006-11-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
J.Med.Chem., 49, 2006
2HDV
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BU of 2hdv by Molmil
Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B
分子名称: SH2-B PH domain containing signaling mediator 1 gamma isoform
著者Hu, J, Hubbard, S.R.
登録日2006-06-20
公開日2006-08-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HDX
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Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
分子名称: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform
著者Hu, J, Hubbard, S.R.
登録日2006-06-21
公開日2006-08-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HMH
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Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.
分子名称: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3
著者Bergamin, E, Wu, J, Hubbard, S.R.
登録日2006-07-11
公開日2006-08-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
Structure, 14, 2006
2IZV
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CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ...
著者Debreczeni, J.E, Bullock, A, Papagrigoriou, E, Turnbull, A, Pike, A.C.W, Gorrec, F, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Knapp, S.
登録日2006-07-26
公開日2006-08-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Structure, 15, 2007
2HUW
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BU of 2huw by Molmil
X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
分子名称: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION
著者Benfield, A.P, Martin, S.F.
登録日2006-07-27
公開日2006-08-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
Angew.Chem.Int.Ed.Engl., 45, 2006
2DVJ
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BU of 2dvj by Molmil
phosphorylated Crk-II
分子名称: V-crk sarcoma virus CT10 oncogene homolog, isoform a
著者Kobashigawa, Y, Inagaki, F.
登録日2006-07-31
公開日2007-05-08
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Nat.Struct.Mol.Biol., 14, 2007
2DX0
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BU of 2dx0 by Molmil
Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
分子名称: Phospholipase C, gamma 2, SULFATE ION
著者Handa, N, Takagi, T, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-08-22
公開日2007-09-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
To be Published
2OQ1
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Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide
分子名称: LEAD (II) ION, T-cell surface glycoprotein CD3 zeta chain, Tyrosine-protein kinase ZAP-70
著者Hatada, M.H, Laird, E.R, Green, J, Morgenstern, J, Ram, M.K.
登録日2007-01-30
公開日2007-03-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular basis for the interaction of ZAP-70 with the T-cell receptor
Nature, 377, 1995
2ECD
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BU of 2ecd by Molmil
Solution structure of the human ABL2 SH2 domain
分子名称: Tyrosine-protein kinase ABL2
著者Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-02-13
公開日2008-02-19
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the human ABL2 SH2 domain
To be Published
2OZO
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Autoinhibited intact human ZAP-70
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase ZAP-70
著者Deindl, S, Kadlecek, T.A, Brdicka, T, Cao, X, Weiss, A, Kuriyan, J.
登録日2007-02-26
公開日2007-05-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70.
Cell(Cambridge,Mass.), 129, 2007
2EKX
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Solution structure of the human BMX SH2 domain
分子名称: Cytoplasmic tyrosine-protein kinase BMX
著者Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-26
公開日2007-10-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the human BMX SH2 domain
To be Published
2EO3
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Solution structure of the SH2 domain from human Crk-like protein
分子名称: Crk-like protein
著者Kurosaki, C, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-28
公開日2008-04-08
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain from human Crk-like protein
To be Published
2EOB
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Solution structure of the second SH2 domain from rat PLC gamma-2
分子名称: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2
著者Sano, R, Hayashi, F, Nagashima, T, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-29
公開日2008-04-01
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the second SH2 domain from rat PLC gamma-2
To be Published
2EO6
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Solution structure of the SH2 domain from mouse B-cell linker protein BLNK
分子名称: B-cell linker protein
著者Sano, R, Hayashi, F, Kurosaki, C, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-29
公開日2008-04-01
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the SH2 domain from mouse B-cell linker protein BLNK
To be Published
2YSX
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Solution structure of the human SHIP SH2 domain
分子名称: Signaling inositol polyphosphate phosphatase SHIP II
著者Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-04-04
公開日2008-04-08
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the human SHIP SH2 domain
To be Published
2YU7
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Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
分子名称: Tyrosine-protein phosphatase non-receptor type 6, natural killer group 2A
著者Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-04-05
公開日2008-04-15
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
To be Published

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