PDB: 364 件ウェブページステータス検索Chemie searchBIRD

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7UHY	Human GATOR2 complex 分子名称: GATOR complex protein MIOS, GATOR complex protein WDR24, GATOR complex protein WDR59, ... 著者 Rogala, K.B, Valenstein, M.L, Lalgudi, P.V. 登録日 2022-03-27 公開日 2022-07-20 最終更新日 2022-08-03 実験手法 ELECTRON MICROSCOPY (3.66 Å) 主引用文献 Structure of the nutrient-sensing hub GATOR2. Nature, 607, 2022
4L45	Crystal structures of human p70S6K1-T389E 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L43	Crystal structures of human p70S6K1-T389A (form I) 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L44	Crystal structures of human p70S6K1-T389A (form II) 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L46	Crystal structures of human p70S6K1-WT 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
4L42	Crystal structures of human p70S6K1-PIF 分子名称: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein, SULFATE ION, ... 著者 Wang, J, Zhong, C, Ding, J. 登録日 2013-06-07 公開日 2013-07-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
3R7W	Crystal Structure of Gtr1p-Gtr2p complex 分子名称: GTP-binding protein GTR1, GTP-binding protein GTR2, MAGNESIUM ION, ... 著者 Gong, R, Li, L, Liu, Y, Wang, P, Yang, H, Wang, L, Cheng, J, Guan, K.L, Xu, Y. 登録日 2011-03-23 公開日 2011-08-24 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.773 Å) 主引用文献 Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation Genes Dev., 25, 2011
7QAJ	ZK002 with Anti-angiogenic and Anti-inflamamtory Properties 分子名称: SULFATE ION, Snaclec clone 2100755 alpha, Snaclec clone 2100755 beta 著者 Wong, W.Y, Chan, B.D, Muk Lan Lee, M, Dai, X, Tsim, K.W.K, Hsiao, W.L.W, Li, M, Li, X.Y, Tai, W.C.S. 登録日 2021-11-17 公開日 2023-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties. Front Pharmacol, 14, 2023
6CET	Cryo-EM structure of GATOR1 分子名称: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3 著者 Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. 登録日 2018-02-12 公開日 2018-03-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
6CES	Cryo-EM structure of GATOR1-RAG 分子名称: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... 著者 Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. 登録日 2018-02-12 公開日 2018-03-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
7K0D	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to mTORC1/2 inhibitor AZD3147 分子名称: N-(4-{4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)-N'-(2-hydroxyethyl)thiourea, Transcription initiation factor TFIID subunit 1 著者 Karim, M.R, Schonbrunn, E. 登録日 2020-09-04 公開日 2021-09-22 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
3IBE	Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma 分子名称: 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Bard, J, Svenson, K. 登録日 2009-07-15 公開日 2009-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.798 Å) 主引用文献 ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines. J.Med.Chem., 52, 2009
5C0V	Structure of the LARP1-unique domain DM15 分子名称: La-related protein 1, SULFATE ION 著者 Lahr, R.M, Berman, A.J. 登録日 2015-06-12 公開日 2015-08-05 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence. Nucleic Acids Res., 43, 2015
2L0X	Solution structure of the 21 kDa GTPase RHEB bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Stoll, R, Heumann, R, Berghaus, C, Kock, G. 登録日 2010-07-19 公開日 2010-08-04 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J.Biol.Chem., 285, 2010
4ZC4	Crystal structure of LARP1-unique domain DM15 分子名称: La-related protein 1, SULFATE ION 著者 Lahr, R.M, Berman, A.J. 登録日 2015-04-15 公開日 2015-08-05 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence. Nucleic Acids Res., 43, 2015
6Z6M	Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. 登録日 2020-05-28 公開日 2020-07-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Plos Biol., 18, 2020
6Z6N	Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1) 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Wells, J.N, Buschauer, R, Mackens-Kiani, T, Best, K, Kratzat, H, Berninghausen, O, Becker, T, Cheng, J, Beckmann, R. 登録日 2020-05-28 公開日 2020-07-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Plos Biol., 18, 2020
6XK9	Cereblon in complex with DDB1, CC-90009, and GSPT1 分子名称: 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... 著者 Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P. 登録日 2020-06-25 公開日 2020-12-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.64 Å) 主引用文献 CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood, 137, 2021
4UED	Complex of human eIF4E with the 4E binding protein 4E-BP1 分子名称: EUKARYOTIC TRANSLATION FACTOR 4E-BINDING PROTEIN 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
3L54	Structure of Pi3K gamma with inhibitor 分子名称: 6-(1H-pyrazolo[3,4-b]pyridin-5-yl)-4-pyridin-4-ylquinoline, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Elkins, P.A, Smallwood, A.M. 登録日 2009-12-21 公開日 2010-06-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin. ACS Med Chem Lett, 1, 2010
3L08	Structure of Pi3K gamma with a potent inhibitor: GSK2126458 分子名称: 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Elkins, P.A, Marrero, E.M. 登録日 2009-12-09 公開日 2010-06-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin. ACS Med Chem Lett, 1, 2010
4DK5	Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor 分子名称: 4-(2-[(6-methoxypyridin-3-yl)amino]-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Whittington, D.A, Tang, J, Yakowec, P. 登録日 2012-02-03 公開日 2012-05-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases. J.Med.Chem., 55, 2012
3NR5	Crystal structure of human Maf1 分子名称: Repressor of RNA polymerase III transcription MAF1 homolog 著者 Ringel, R, Vannini, A, Kusser, A.G, Berninghausen, O, Kassavetis, G.A, Cramer, P. 登録日 2010-06-30 公開日 2010-10-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Molecular Basis of RNA Polymerase III Transcription Repression by Maf1 Cell(Cambridge,Mass.), 143, 2010
8K2C	Cryo-EM structure of the human 80S ribosome with Tigecycline 分子名称: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... 著者 Li, X, Wang, M, Cheng, J. 登録日 2023-07-12 公開日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
8K2D	Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A 分子名称: 18S rRNA, 23S rRNA, 40S ribosomal protein S1-A, ... 著者 Buschauer, R, Beckmann, R, Cheng, J. 登録日 2023-07-12 公開日 2024-07-10 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024

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