PDB: 98041 件ウェブページステータス検索Chemie searchBIRD

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7DPI	Plasmodium falciparum cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD7929 分子名称: (8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanine--tRNA ligase, ... 著者 Manmohan, S, Malhotra, N, Harlos, K, Manickam, Y, Sharma, A. 登録日 2020-12-19 公開日 2022-03-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.597 Å) 主引用文献 Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development. Structure, 30, 2022
6KJM	Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis 分子名称: ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... 著者 Ramachandran, R, Shukla, A, Afsar, M. 登録日 2019-07-22 公開日 2020-07-22 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213, 2021
1RKA	THE APO FORM OF E. COLI RIBOKINASE 分子名称: PROTEIN (RIBOKINASE) 著者 Sigrell, J.A, Cameron, A.D, Mowbray, S.L. 登録日 1999-03-22 公開日 1999-08-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Induced fit on sugar binding activates ribokinase. J.Mol.Biol., 290, 1999
2FEQ	orally active thrombin inhibitors 分子名称: Decapeptide Hirudin Analogue, N-(CARBOXYMETHYL)-3-CYCLOHEXYL-D-ALANYL-N-({4-[(E)-AMINO(IMINO)METHYL]-1,3-THIAZOL-2-YL}METHYL)-L-PROLINAMIDE, Thrombin heavy chain, ... 著者 Mack, H, Baucke, D, Hornberger, W, Lange, U.E.W, Hoeffken, H.W. 登録日 2005-12-16 公開日 2006-08-08 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety Bioorg.Med.Chem.Lett., 16, 2006
7E2M	Crystal structure of the RWD domain of human GCN2 - 2 分子名称: eIF-2-alpha kinase GCN2 著者 Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. 登録日 2021-02-05 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
7E2K	Crystal structure of the RWD domain of human GCN2 - 1 分子名称: eIF-2-alpha kinase GCN2 著者 Hei, Z, Zhou, J, Liu, Z, Wang, J, Fang, P. 登録日 2021-02-05 公開日 2021-03-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.041 Å) 主引用文献 Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochem.Biophys.Res.Commun., 549, 2021
7K5C	Structure of T7 DNA ejectosome periplasmic tunnel 分子名称: Internal virion protein gp15, Peptidoglycan transglycosylase gp16 著者 Swanson, N, Cingolani, G, Pumroy, R. 登録日 2020-09-16 公開日 2021-07-28 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 angstrom resolution. Mol.Cell, 81, 2021
2FES	Orally active thrombin inhibitors 分子名称: Decapeptide Hirudin Analogue, N-(CARBOXYMETHYL)-3-CYCLOHEXYL-D-ALANYL-N-({5-[(E)-AMINO(IMINO)METHYL]THIEN-2-YL}METHYL)-L-PROLINAMIDE, Thrombin heavy chain, ... 著者 Hoeffken, H.W. 登録日 2005-12-16 公開日 2006-05-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg.Med.Chem.Lett., 16, 2006
4CMG	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-16 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CLR	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: 2-amino-5-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE 1 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CMC	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE 1 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-16 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CME	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE 1 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-16 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CM9	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-amino-5,6-diphenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, ACETATE ION, ... 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CLD	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: 2-amino-4-thiomorpholino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-14 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CLH	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: 4-thiomorpholino-7H-pyrrolo[2,3-d]pyrimidin-2-amine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-14 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
4CMJ	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: 6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE 1 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-16 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
2POL	THREE-DIMENSIONAL STRUCTURE OF THE BETA SUBUNIT OF ESCHERICHIA COLI DNA POLYMERASE III HOLOENZYME: A SLIDING DNA CLAMP 分子名称: DNA POLYMERASE III (BETA SUBUNIT) 著者 Kong, X.-P, Kuriyan, J. 登録日 1992-11-13 公開日 1994-01-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. Cell(Cambridge,Mass.), 69, 1992
7ELT	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Trp-AMP 分子名称: TRYPTOPHANYL-5'AMP, Tryptophan--tRNA ligase 著者 Xu, M, Chen, S. 登録日 2021-04-12 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
7ENS	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Indolmycin and ATP 分子名称: (5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5H)-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Xu, M, Chen, S. 登録日 2021-04-19 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
7EL8	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase 分子名称: Tryptophan--tRNA ligase 著者 Xu, M, Chen, S. 登録日 2021-04-09 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
7ENT	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-13 and ATP 分子名称: (5S)-2-(methylamino)-5-[(1R)-1-(4-methyl-1H-indol-3-yl)ethyl]-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Xu, M, Chen, S. 登録日 2021-04-19 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
4CM8	Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor 分子名称: (E)-2,4-diamino-6-(4-methylstyryl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETATE ION, ... 著者 Barrack, K.L, Hunter, W.N. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57, 2014
7E5E	Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20 分子名称: CHLORIDE ION, GD20, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Hu, Q, Dai, S, Shokat, K.M. 登録日 2021-02-18 公開日 2022-03-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 185, 2022
6J7H	Crystal structure of blue fluorescent protein from metagenomic library 分子名称: Blue fluorescent protein 著者 Seo, P.W, Kim, J.S. 登録日 2019-01-18 公開日 2019-09-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.309 Å) 主引用文献 Structure-Guided Generation of a Redox-Independent Blue Fluorescent Protein from mBFP. J.Mol.Biol., 431, 2019
6J7U	Crystal structure of blue fluorescent protein from metagenomic library in complex with NADPH 分子名称: Blue fluorescent protein, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seo, P.W, Kim, J.S. 登録日 2019-01-18 公開日 2019-09-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.302 Å) 主引用文献 Structure-Guided Generation of a Redox-Independent Blue Fluorescent Protein from mBFP. J.Mol.Biol., 431, 2019

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