2FEQ

orally active thrombin inhibitors

Summary for 2FEQ

• Entry DOI: 10.2210/pdb2feq/pdb
• Related: 1O0D
• Related PRD ID: PRD_000480 PRD_000612
• Descriptor: Thrombin light chain, Thrombin heavy chain, Decapeptide Hirudin Analogue, ... (5 entities in total)
• Functional Keywords: thrombin inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35855.94

Authors

Mack, H.,Baucke, D.,Hornberger, W.,Lange, U.E.W.,Hoeffken, H.W. (deposition date: 2005-12-16, release date: 2006-08-08, Last modification date: 2018-04-04)

• Primary citation: Mack, H.,Baucke, D.,Hornberger, W.,Lange, U.E.W.,Seitz, W.,Hoeffken, H.W.; Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety; Bioorg.Med.Chem.Lett., 16:2641-2647, 2006; PubMed: 16517159; DOI: 10.1016/j.bmcl.2006.02.040

Experimental method

X-RAY DIFFRACTION (2.44 Å)