3TO6
 
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4J5X
 | | Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex | | 分子名称: | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... | | 著者 | Wallace, B.D, Betts, L, Redinbo, M.R. | | 登録日 | 2013-02-10 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha.
J.Mol.Biol., 425, 2013
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7GQT
 | | Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7GQS
 | | Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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7GQU
 | | Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ... | | 著者 | Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G. | | 登録日 | 2023-10-19 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
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2LG2
 | | Structure of the duplex containing HNE derived (6S,8R,11S) N2-dG cyclic hemiacetal when placed opposite dT | | 分子名称: | (2R,5S)-5-pentyltetrahydrofuran-2-ol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*TP*GP*CP*TP*AP*GP*C)-3') | | 著者 | Huang, H, Wang, H, Kozekova, A, Lloyd, R.S, Rizzo, C.J, Stone, M.P. | | 登録日 | 2011-07-19 | | 公開日 | 2012-08-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ring-chain tautomerization of trans-4-hydroxynonenal derived (6S,8R,11S) gamma-hydroxy-1,N2-propano-deoxyguanosine adduct when placed opposite 2'-deoxythymidine in duplex
To be Published
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4ONL
 | | Crystal structure of human Mms2/Ubc13_D81N, R85S, A122V, N123P | | 分子名称: | Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 | | 著者 | Hodge, C.D, Edwards, R.A, Glover, J.N.M. | | 登録日 | 2014-01-28 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.
Acs Chem.Biol., 10, 2015
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4ORH
 | | Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer | | 分子名称: | E3 ubiquitin-protein ligase RNF8, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2, ... | | 著者 | Campbell, S.J, Edwards, R.A, Glover, J.N.M. | | 登録日 | 2014-02-11 | | 公開日 | 2014-02-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (4.802 Å) | | 主引用文献 | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
J.Biol.Chem., 287, 2012
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4PRX
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4CWE
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4PU9
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3F1Z
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4PRV
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3F5C
 | | Structure of Dax-1:LRH-1 complex | | 分子名称: | Nuclear receptor subfamily 0 group B member 1, Nuclear receptor subfamily 5 group A member 2 | | 著者 | Fletterick, R.J, Sablin, E.P. | | 登録日 | 2008-11-03 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Proc.Natl.Acad.Sci.USA, 105, 2008
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3VCF
 | | SSV1 integrase C-terminal catalytic domain (174-335aa) | | 分子名称: | Probable integrase | | 著者 | Ouyang, S, Liang, W, Huang, L, Liu, Z.-J. | | 登録日 | 2012-01-04 | | 公開日 | 2012-05-30 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase.
Acta Crystallogr.,Sect.D, 68, 2012
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2RN2
 | | STRUCTURAL DETAILS OF RIBONUCLEASE H FROM ESCHERICHIA COLI AS REFINED TO AN ATOMIC RESOLUTION | | 分子名称: | RIBONUCLEASE H | | 著者 | Katayanagi, K, Miyagawa, M, Matsushima, M, Ishikawa, M, Kanaya, S, Nakamura, H, Ikehara, M, Matsuzaki, T, Morikawa, K. | | 登録日 | 1992-04-15 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution.
J.Mol.Biol., 223, 1992
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4HRE
 | | Crystal Structure of p11/Annexin A2 Heterotetramer in Complex with SMARCA3 Peptide | | 分子名称: | Annexin A2, Helicase-like transcription factor, Protein S100-A10 | | 著者 | Gao, P, Patel, D.J. | | 登録日 | 2012-10-27 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7852 Å) | | 主引用文献 | SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
Cell(Cambridge,Mass.), 152, 2013
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4HRH
 | | Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide | | 分子名称: | Helicase-like transcription factor, Protein S100-A10, Annexin A2, ... | | 著者 | Gao, P, Patel, D.J. | | 登録日 | 2012-10-27 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | | 主引用文献 | SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
Cell(Cambridge,Mass.), 152, 2013
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3CZ7
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8UQE
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density) | | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.562 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQA
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ... | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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8UQB
 | | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1) | | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | | 登録日 | 2023-10-23 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
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1KHM
 | | C-TERMINAL KH DOMAIN OF HNRNP K (KH3) | | 分子名称: | PROTEIN (HNRNP K) | | 著者 | Baber, J, Libutti, D, Levens, D, Tjandra, N. | | 登録日 | 1999-01-07 | | 公開日 | 2000-01-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor.
J.Mol.Biol., 289, 1999
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3CW4
 | | Large c-terminal domain of influenza a virus RNA-dependent polymerase PB2 | | 分子名称: | Polymerase basic protein 2 | | 著者 | Kuzuhara, T, Kise, D, Yoshida, H, Horita, T, Murasaki, Y, Utsunomiya, H, Fujiki, H, Tsuge, H. | | 登録日 | 2008-04-21 | | 公開日 | 2009-01-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue
J.Biol.Chem., 284, 2009
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4DJA
 | | Crystal structure of a prokaryotic (6-4) photolyase PhrB from Agrobacterium Tumefaciens with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore at 1.45A resolution | | 分子名称: | 1-deoxy-1-(6,7-dimethyl-2,4-dioxo-3,4-dihydropteridin-8(2H)-yl)-D-ribitol, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Scheerer, P, Zhang, F, Oberpichler, I, Lamparter, T, Krauss, N. | | 登録日 | 2012-02-01 | | 公開日 | 2013-04-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore.
Proc.Natl.Acad.Sci.USA, 110, 2013
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