5VZ8
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![BU of 5vz8 by Molmil](/molmil-images/mine/5vz8) | Post-catalytic complex of human Polymerase Mu (G433A) mutant with incoming UTP | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2017-05-27 | 公開日 | 2017-07-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
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5VZB
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![BU of 5vzb by Molmil](/molmil-images/mine/5vzb) | Post-catalytic complex of human Polymerase Mu (G433S) mutant with incoming UTP | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2017-05-27 | 公開日 | 2017-07-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
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7EGS
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![BU of 7egs by Molmil](/molmil-images/mine/7egs) | The crystal structure of lobe domain of E. coli RNA polymerase complexed with the C-terminal domain of UvrD | 分子名称: | DNA helicase II, DNA-directed RNA polymerase subunit beta, GLYCEROL | 著者 | Zheng, F, Shen, L, Li, L, Zhang, Y. | 登録日 | 2021-03-26 | 公開日 | 2022-04-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crucial role and mechanism of transcription-coupled DNA repair in bacteria. Nature, 604, 2022
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3H5S
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![BU of 3h5s by Molmil](/molmil-images/mine/3h5s) | Hepatitis C virus polymerase NS5B with saccharin inhibitor | 分子名称: | (5S)-5-tert-butyl-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-3-[8-(methylsulfonyl)-1,1-dioxido-6,7,8,9-tetrahydroisothiazolo[4,5-h]isoquinolin-3-yl]-1,5-dihydro-2H-pyrrol-2-one, RNA-directed RNA polymerase | 著者 | Harris, S.F, Wong, A. | 登録日 | 2009-04-22 | 公開日 | 2009-09-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides Bioorg.Med.Chem.Lett., 19, 2009
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5CE7
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![BU of 5ce7 by Molmil](/molmil-images/mine/5ce7) | Structure of a non-canonical CID of Ctk3 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CTD kinase subunit gamma | 著者 | Muehlbacher, W, Mayer, A, Sun, M, Remmert, M, Cheung, A.C, Niesser, J, Soeding, J, Cramer, P. | 登録日 | 2015-07-06 | 公開日 | 2015-08-05 | 最終更新日 | 2015-09-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold. Proteins, 83, 2015
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6WIE
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![BU of 6wie by Molmil](/molmil-images/mine/6wie) | Post-catalytic nicked complex of human Polymerase Mu on a complementary DNA double-strand break substrate | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*CP*G)-3'), ... | 著者 | Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. | 登録日 | 2020-04-09 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
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3H5U
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![BU of 3h5u by Molmil](/molmil-images/mine/3h5u) | Hepatitis C virus polymerase NS5B with saccharin inhibitor 1 | 分子名称: | N-({3-[(5S)-5-tert-butyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzisothiazol-7-yl}methyl)methanesulfonamide, RNA-directed RNA polymerase | 著者 | Harris, S.F, Ghate, M. | 登録日 | 2009-04-22 | 公開日 | 2009-09-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides Bioorg.Med.Chem.Lett., 19, 2009
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6IDO
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![BU of 6ido by Molmil](/molmil-images/mine/6ido) | Crystal structure of Klebsiella pneumoniae sigma4 of sigmaS fusing with the RNA polymerase beta-flap-tip-helix in complex with -35 element DNA | 分子名称: | DNA (5'-D(P*CP*CP*AP*CP*TP*TP*GP*AP*CP*AP*AP*AP*TP*CP*G)-3'), DNA (5'-D(P*GP*AP*TP*TP*TP*GP*TP*CP*AP*AP*GP*TP*GP*GP*C)-3'), RNA polymerase sigma factor RpoS,RNA polymerase beta-flap-tip-helix | 著者 | Lou, Y.C, Chien, C.Y, Chen, C, Hsu, C.H. | 登録日 | 2018-09-10 | 公開日 | 2019-09-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.748 Å) | 主引用文献 | Structural basis for -35 element recognition by sigma4chimera proteins and their interactions with PmrA response regulator. Proteins, 88, 2020
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8V38
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3SKE
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![BU of 3ske by Molmil](/molmil-images/mine/3ske) | I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles | 分子名称: | 1-[(2-aminopyridin-4-yl)methyl]-3-(2,4-dioxo-1,2-dihydrothieno[3,4-d]pyrimidin-3(4H)-yl)-5-(trifluoromethyl)-1H-indole-2-carboxylic acid, HCV NS5B RNA_DEPENDENT RNA POLYMERASE, PHOSPHATE ION | 著者 | Lesburg, C.A, Anilkumar, G.N. | 登録日 | 2011-06-22 | 公開日 | 2011-08-31 | 最終更新日 | 2012-09-26 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles. Bioorg.Med.Chem.Lett., 21, 2011
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2I1R
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![BU of 2i1r by Molmil](/molmil-images/mine/2i1r) | Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure | 分子名称: | (5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE, RNA-directed RNA polymerase (NS5B) (P68) | 著者 | Yao, N, Yan, S. | 登録日 | 2006-08-14 | 公開日 | 2006-10-31 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure. Bioorg.Med.Chem.Lett., 17, 2007
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2WNM
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![BU of 2wnm by Molmil](/molmil-images/mine/2wnm) | Solution structure of Gp2 | 分子名称: | GENE 2 | 著者 | Camara, B, Liu, M, Shadrinc, A, Liu, B, Simpson, P, Weinzierl, R, Severinovc, K, Cota, E, Matthews, S, Wigneshweraraj, S.R. | 登録日 | 2009-07-13 | 公開日 | 2010-02-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site. Proc.Natl.Acad.Sci.USA, 107, 2010
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3OMX
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![BU of 3omx by Molmil](/molmil-images/mine/3omx) | Crystal structure of Ssu72 with vanadate complex | 分子名称: | CG14216, VANADATE ION | 著者 | Zhang, Y, Zhang, M, Zhang, Y. | 登録日 | 2010-08-27 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3366 Å) | 主引用文献 | Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem.J., 434, 2011
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4IZ0
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![BU of 4iz0 by Molmil](/molmil-images/mine/4iz0) | Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide | 分子名称: | 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide, RNA-directed RNA polymerase | 著者 | Coulombe, R. | 登録日 | 2013-01-29 | 公開日 | 2013-04-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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6PTG
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![BU of 6ptg by Molmil](/molmil-images/mine/6ptg) | |
4KBJ
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3Q0Z
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![BU of 3q0z by Molmil](/molmil-images/mine/3q0z) | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, RNA-directed RNA polymerase, SULFATE ION | 著者 | Sheriff, S. | 登録日 | 2010-12-16 | 公開日 | 2011-04-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus. Bioorg.Med.Chem.Lett., 21, 2011
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6T8H
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![BU of 6t8h by Molmil](/molmil-images/mine/6t8h) | Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi | 分子名称: | DNA polymerase II small subunit, DNA polymerase sliding clamp, DNA primer, ... | 著者 | Madru, C, Raia, P, Hugonneau Beaufet, I, Pehau-Arnaudet, G, England, P, Lindhal, E, Delarue, M, Carroni, M, Sauguet, L. | 登録日 | 2019-10-24 | 公開日 | 2020-03-04 | 最終更新日 | 2020-04-08 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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7X7H
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![BU of 7x7h by Molmil](/molmil-images/mine/7x7h) | Crystal structure of Fructose regulator/Histidine phosphocarrier protein complex from Vibrio cholerae | 分子名称: | CALCIUM ION, Catabolite repressor/activator, HPr family phosphocarrier protein | 著者 | Kim, M.-K, Zhang, J, Yoon, C.-K, Seok, Y.-J. | 登録日 | 2022-03-09 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | HPr prevents FruR-mediated facilitation of RNA polymerase binding to the fru promoter in Vibrio cholerae. Nucleic Acids Res., 51, 2023
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4M04
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![BU of 4m04 by Molmil](/molmil-images/mine/4m04) | Human DNA Polymerase Mu ternary complex | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2013-08-01 | 公開日 | 2014-02-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Sustained active site rigidity during synthesis by human DNA polymerase mu. Nat.Struct.Mol.Biol., 21, 2014
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5TXX
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![BU of 5txx by Molmil](/molmil-images/mine/5txx) | DNA Polymerase Mu Pre-Catalytic Ground State Ternary Complex, Ca2+ | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-17 | 公開日 | 2017-08-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.948 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5UH7
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5VZI
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![BU of 5vzi by Molmil](/molmil-images/mine/5vzi) | Post-catalytic complex of human Polymerase Mu (W434H) mutant with incoming dTTP | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2017-05-27 | 公開日 | 2017-07-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
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5VZF
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![BU of 5vzf by Molmil](/molmil-images/mine/5vzf) | Post-catalytic complex of human Polymerase Mu (W434A) mutant with incoming dTTP | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... | 著者 | Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. | 登録日 | 2017-05-27 | 公開日 | 2017-07-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
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3FDF
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![BU of 3fdf by Molmil](/molmil-images/mine/3fdf) | Crystal structure of the serine phosphatase of RNA polymerase II CTD (SSU72 superfamily) from Drosophila melanogaster. Orthorhombic crystal form. Northeast Structural Genomics Consortium target FR253. | 分子名称: | FR253 | 著者 | Kuzin, A.P, Chen, Y, Seetharaman, J, Forouhar, F, Chinag, Y, Fang, Y, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-11-25 | 公開日 | 2009-01-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Orthorombic crystal structure of serine phosphatase of rna polymerase ii ctd from fly drosofila melanogaster. northeast structural genomics consortium target fr253. To be Published
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