8DSY
| PPARg bound to inverse agonist H3B-343 | 分子名称: | Peroxisome proliferator-activated receptor gamma, {5-[(5-{[(4-tert-butylphenyl)methyl]carbamoyl}-2,3-dimethyl-1H-indol-1-yl)methyl]-2-chlorophenoxy}acetic acid | 著者 | Larsen, N.A. | 登録日 | 2022-07-24 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPAR gamma by inverse agonists. J.Biol.Chem., 298, 2022
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2AXY
| Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA | 分子名称: | C-rich strand of human telomeric dna, Poly(rC)-binding protein 2 | 著者 | Du, Z, Lee, J.K, Tjhen, R.J, Li, S, Stroud, R.M, James, T.L. | 登録日 | 2005-09-06 | 公開日 | 2005-09-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of the First KH Domain of Human Poly(C)-binding Protein-2 in Complex with a C-rich Strand of Human Telomeric DNA at 1.7 A J.Biol.Chem., 280, 2005
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6QMC
| Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction | 分子名称: | (3~{S})-3-(4-chlorophenyl)-3-(2-oxidanylidene-1~{H}-pyridin-4-yl)propanoic acid, Kelch-like ECH-associated protein 1 | 著者 | Davies, T.G. | 登録日 | 2019-02-07 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. J.Med.Chem., 62, 2019
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7RDN
| Crystal structure of S. cerevisiae pre-mRNA leakage protein 39 (Pml39) | 分子名称: | Pre-mRNA leakage protein 39, ZINC ION | 著者 | Hashimoto, H, Ramirez, D.H, Pawlak, N, Blobel, G, Palancade, B, Debler, E.W. | 登録日 | 2021-07-09 | 公開日 | 2022-07-27 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Sci Rep, 12, 2022
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4ZG0
| Crystal structure of Mouse Syndesmos protein | 分子名称: | Protein syndesmos | 著者 | Lee, I, Kim, H, Yoo, J, Cho, H, Lee, W. | 登録日 | 2015-04-22 | 公開日 | 2016-04-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | Crystal structure of syndesmos and its interaction with Syndecan-4 proteoglycan Biochem.Biophys.Res.Commun., 463, 2015
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1GV0
| Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | 分子名称: | MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | 登録日 | 2002-02-04 | 公開日 | 2002-02-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases J.Mol.Biol., 318, 2002
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8F28
| Lysozyme Structures from Single-Entity Crystallization Method NanoAC | 分子名称: | ACETATE ION, CHLORIDE ION, Lysozyme C, ... | 著者 | Yang, R, Sankaran, B, Ogbonna, E, Wang, G. | 登録日 | 2022-11-07 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | A Single-Entity Method for Actively Controlled Nucleation and High-Quality Protein Crystal Synthesis. Anal.Chem., 95, 2023
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7UDI
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7UQO
| Pathogenesis related 10-10 (S)-tetrahydropapaverine complex | 分子名称: | (1~{S})-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, Pathogenesis Related 10-10 protein | 著者 | Carr, S.C, Ng, K.K.S. | 登録日 | 2022-04-19 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun, 13, 2022
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7UQN
| Pathogenesis related 10-10 noscapine complex | 分子名称: | Pathogenesis Related 10-10 protein, noscapine | 著者 | Carr, S.C, Ng, K.K.S. | 登録日 | 2022-04-19 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun, 13, 2022
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6QMJ
| Small molecule inhibitor of the KEAP1-NRF2 protein-protein interaction | 分子名称: | (3~{S})-3-(7-methoxy-1-methyl-benzotriazol-5-yl)-3-[4-methyl-3-[[methyl(phenylsulfonyl)amino]methyl]phenyl]propanoic acid, CHLORIDE ION, Kelch-like ECH-associated protein 1, ... | 著者 | Davies, T.G. | 登録日 | 2019-02-07 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. J.Med.Chem., 62, 2019
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7UQL
| Pathogenesis related 10-10 app from | 分子名称: | Pathogenesis Related 10-10 protein | 著者 | Carr, S.C, Ng, K.K.S. | 登録日 | 2022-04-19 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun, 13, 2022
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7UQM
| Pathogenesis related 10-10 papaverine complex | 分子名称: | 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE, Pathogenesis Related 10-10 protein | 著者 | Carr, S.C, Ng, K.K.S. | 登録日 | 2022-04-19 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation. Nat Commun, 13, 2022
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4TWU
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8EO2
| Lufaxin a bifunctional inhibitor of complement and coagulation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | 著者 | Andersen, J.F, Strayer, E.C. | 登録日 | 2022-10-01 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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8ENU
| Structure of the C3bB proconvertase in complex with lufaxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2022-09-30 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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4TUG
| Crystal structure of MjMre11-DNA2 complex | 分子名称: | DNA (5'-D(P*CP*TP*GP*TP*CP*CP*TP*AP*CP*GP*TP*GP*CP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*CP*GP*TP*AP*GP*GP*AP*CP*AP*GP*C)-3'), DNA double-strand break repair protein Mre11, ... | 著者 | Sung, S, Cho, Y. | 登録日 | 2014-06-24 | 公開日 | 2014-10-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA. Embo J., 33, 2014
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4TWV
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7YKD
| Cryo-EM structure of the human chemerin receptor 1 complex with the C-terminal nonapeptide of chemerin | 分子名称: | CHOLESTEROL, Chemerin-like receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Chen, G, Liao, Q, Ye, R.D, Wang, J. | 登録日 | 2022-07-22 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proc.Natl.Acad.Sci.USA, 120, 2023
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4X3V
| Crystal structure of human ribonucleotide reductase 1 bound to inhibitor | 分子名称: | N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE | 著者 | Dealwis, C.G, Ahmad, M.F, Alam, I. | 登録日 | 2014-12-01 | 公開日 | 2015-11-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J.Med.Chem., 58, 2015
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6QV7
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6QVA
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7R2E
| Structure of human Senp7 with SUMO2 | 分子名称: | Sentrin-specific protease 7, Small ubiquitin-related modifier 3, prop-2-en-1-amine | 著者 | Reverter, D, Li, Y. | 登録日 | 2022-02-04 | 公開日 | 2022-12-07 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Structural Basis for the SUMO2 Isoform Specificity of SENP7. J.Mol.Biol., 434, 2022
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7YK3
| Crystal structure of DarTG toxin-antitoxin complex from Mycobacterium tuberculosis | 分子名称: | DNA ADP-ribosyl glycohydrolase, DNA ADP-ribosyl transferase, PHOSPHATE ION | 著者 | Deep, A, Kaur, J, Singh, L, Thakur, K.G. | 登録日 | 2022-07-21 | 公開日 | 2023-05-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited. Structure, 31, 2023
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7RDG
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