3QCS
 
 | | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine | | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2H-indazol-3-amine, GLYCEROL, ... | | 著者 | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | | 登録日 | 2011-01-17 | | 公開日 | 2011-03-09 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.487 Å) | | 主引用文献 | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors.
J.Med.Chem., 54, 2011
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3IU9
 | | M. tuberculosis methionine aminopeptidase with Ni inhibitor T07 | | 分子名称: | 5-[(2,4-dichlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine, CHLORIDE ION, Methionine aminopeptidase, ... | | 著者 | Ye, Q.Z, Lu, J.P. | | 登録日 | 2009-08-30 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase
J.Med.Chem., 53, 2010
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3QCU
 | | Crystal structure of the LT3015 antibody Fab fragment in complex with lysophosphatidic acid (14:0) | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, LT3015 antibody Fab fragment, heavy chain, ... | | 著者 | Fleming, J.K, Wojciak, J.M, Campbell, M.-A, Huxford, T. | | 登録日 | 2011-01-17 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | | 主引用文献 | Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
J.Mol.Biol., 408, 2011
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3QD6
 | | Crystal structure of the CD40 and CD154 (CD40L) complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand, Tumor necrosis factor receptor superfamily member 5 | | 著者 | Lee, J.-O, Kim, Y.J, Song, D.H, Kim, H.M, Park, B.S. | | 登録日 | 2011-01-18 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation
J.Biol.Chem., 286, 2011
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3IVD
 | | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine | | 分子名称: | CHLORIDE ION, FE (III) ION, MANGANESE (II) ION, ... | | 著者 | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-08-31 | | 公開日 | 2009-09-29 | | 最終更新日 | 2021-02-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine
To be Published
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3IK7
 | | Human glutathione transferase a4-4 with GSDHN | | 分子名称: | (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((3S,4R)-1,4-dihydroxynonan-3-ylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid, Glutathione S-transferase A4, SULFATE ION | | 著者 | Balogh, L.M, Le Trong, I, Atkins, W.M, Stenkamp, R.E. | | 登録日 | 2009-08-05 | | 公開日 | 2010-06-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.
Biochemistry, 49, 2010
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3IKR
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3IWO
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3IXG
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3QGE
 | | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide | | 分子名称: | (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, (2R)-4-(2,6-dimethoxypyrimidin-4-yl)-N-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazine-2-carboxamide, RNA-directed RNA polymerase, ... | | 著者 | Sheriff, S. | | 登録日 | 2011-01-24 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
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3I7Y
 | | High pressure structure of I106A variant of RNase A (0.48 GPa) | | 分子名称: | CHLORIDE ION, Ribonuclease pancreatic | | 著者 | Lewinski, K, Kurpiewska, K, Dziubek, K, Katrusiak, A, Font, J, Ribo, M, Vilanova, M. | | 登録日 | 2009-07-09 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural investigation of ribonuclease A conformational preferences using high pressure protein crystallography
Chem.Phys., 468, 2016
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3QH2
 | | Crystal structure of TenI from Bacillus subtilis complexed with product cThz-P | | 分子名称: | 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, Regulatory protein tenI, SULFATE ION | | 著者 | Han, Y, Zhang, Y, Hazra, A, Chatterjee, A, Lai, R, Begley, T.P, Ealick, S.E. | | 登録日 | 2011-01-25 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.231 Å) | | 主引用文献 | A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase.
J.Am.Chem.Soc., 133, 2011
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3I9A
 | | Crystal structure of human transthyretin variant A25T - #1 | | 分子名称: | TRIETHYLENE GLYCOL, Transthyretin | | 著者 | Palmieri, L.C, Freire, J.B.B, Palhano, F.L, Azevedo, E.P.C, Foguel, D, Lima, L.M.T.R. | | 登録日 | 2009-07-10 | | 公開日 | 2010-08-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystal structure of human transthyretin variant A25T - #1
To be Published
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3I9Q
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3IMY
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3QI7
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3IA8
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3IAJ
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3IAM
 | | Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, reduced, 2 mol/ASU, with bound NADH | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Sazanov, L.A, Berrisford, J.M. | | 登録日 | 2009-07-14 | | 公開日 | 2009-09-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural basis for the mechanism of respiratory complex I
J.Biol.Chem., 284, 2009
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3IP1
 | | Structure of putative alcohol dehydrogenase (TM_042) from Thermotoga maritima | | 分子名称: | Alcohol dehydrogenase, zinc-containing, CADMIUM ION, ... | | 著者 | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-08-15 | | 公開日 | 2009-09-29 | | 最終更新日 | 2021-02-10 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure of putative alcohol dehydrogenase (TM_042) from Thermotoga maritima
To be published
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3QKB
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3ICN
 | | Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl pyrophosphate and 3-Fluoro-1-(2-hydroxy-2,2-bis-phosphono-ethyl)-pyridinium | | 分子名称: | 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ... | | 著者 | Amzel, L.M, Huang, C.H, Gabelli, S.B, Oldfield, E. | | 登録日 | 2009-07-17 | | 公開日 | 2010-02-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.
Proteins, 78, 2010
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3QKV
 | | Crystal structure of fatty acid amide hydrolase with small molecule compound | | 分子名称: | (6-bromo-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidin]-1'-yl)methanol, Fatty-acid amide hydrolase 1 | | 著者 | Min, X, Walker, N.P.C, Wang, Z. | | 登録日 | 2011-02-01 | | 公開日 | 2011-04-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
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3QLC
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3IQT
 | | Structure of the HPT domain of Sensor protein barA from Escherichia coli CFT073. | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Signal transduction histidine-protein kinase barA | | 著者 | Cuff, M.E, Rakowski, E, Kim, Y, Freeman, L, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2009-08-20 | | 公開日 | 2009-09-22 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure of the HPT domain of Sensor protein barA from Escherichia coli CFT073.
TO BE PUBLISHED
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