7VRO
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![BU of 7vro by Molmil](/molmil-images/mine/7vro) | crystal structure of BRD2-BD1 in complex with purine derivative | 分子名称: | Bromodomain-containing protein 2, SULFATE ION, THEOBROMINE | 著者 | Padmanabhan, B, Arole, A, Deshmukh, P, Ashok, S, Mathur, S. | 登録日 | 2021-10-23 | 公開日 | 2023-02-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family. Acta Crystallogr D Struct Biol, 79, 2023
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4WNO
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![BU of 4wno by Molmil](/molmil-images/mine/4wno) | Structure of ULK1 bound to an inhibitor | 分子名称: | N~2~-(4-aminophenyl)-N~4~-(5-cyclopropyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine, Serine/threonine-protein kinase ULK1 | 著者 | Lazarus, M.B, Novotny, C.J, Shokat, K.M. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. Acs Chem.Biol., 10, 2015
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6Y5U
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7T19
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![BU of 7t19 by Molmil](/molmil-images/mine/7t19) | Rev1 Ternary Complex with dGTP and Ca2+ | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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6EZ4
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![BU of 6ez4 by Molmil](/molmil-images/mine/6ez4) | NMR structure of the C-terminal domain of the human RPAP3 protein | 分子名称: | RNA polymerase II-associated protein 3 | 著者 | Fabre, P, Chagot, M.E, Bragantini, B, Manival, X, Quinternet, M. | 登録日 | 2017-11-14 | 公開日 | 2018-04-18 | 最終更新日 | 2024-01-17 | 実験手法 | SOLUTION NMR | 主引用文献 | The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones. Nat Commun, 9, 2018
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7T1B
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![BU of 7t1b by Molmil](/molmil-images/mine/7t1b) | Rev1 Ternary Complex with rCTP and Ca2+ | 分子名称: | CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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5EP1
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![BU of 5ep1 by Molmil](/molmil-images/mine/5ep1) | Quorum-Sensing Signal Integrator LuxO - Catalytic Domain | 分子名称: | ACETATE ION, Putative repressor protein luxO | 著者 | Shah, T, Selcuk, H.B, Jeffrey, P.D, Hughson, F.M. | 登録日 | 2015-11-11 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. Plos Biol., 14, 2016
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7T9F
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![BU of 7t9f by Molmil](/molmil-images/mine/7t9f) | Structure of VcINDY-apo | 分子名称: | DASS family sodium-coupled anion symporter | 著者 | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | 登録日 | 2021-12-19 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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7SQY
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![BU of 7sqy by Molmil](/molmil-images/mine/7sqy) | CSDaV GFP mutant | 分子名称: | Citrus Sudden Death-associated Virus Capsid Protein,Green fluorescent protein,Citrus Sudden Death-associated Virus Capsid Protein | 著者 | Guo, F, Matsumura, E.E, Falk, B.W. | 登録日 | 2021-11-07 | 公開日 | 2022-05-25 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Citrus sudden death-associated virus as a new expression vector for rapid in planta production of heterologous proteins, chimeric virions, and virus-like particles. Biotechnol Rep., 35, 2022
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6M88
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![BU of 6m88 by Molmil](/molmil-images/mine/6m88) | Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with myricetin | 分子名称: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, Inositol polyphosphate multikinase,Inositol polyphosphate multikinase | 著者 | Wang, H, Shears, S.B. | 登録日 | 2018-08-21 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J. Med. Chem., 62, 2019
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7T9G
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![BU of 7t9g by Molmil](/molmil-images/mine/7t9g) | Structure of VcINDY-Na+ | 分子名称: | DASS family sodium-coupled anion symporter, SODIUM ION | 著者 | Sauer, D.B, Marden, J.J, Song, J.M, Wang, D.N. | 登録日 | 2021-12-19 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis of ion - substrate coupling in the Na + -dependent dicarboxylate transporter VcINDY. Nat Commun, 13, 2022
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7VRZ
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![BU of 7vrz by Molmil](/molmil-images/mine/7vrz) | crystal structure of BRD2-BD1 in complex with purine derivative | 分子名称: | Bromodomain-containing protein 2, Doxofylline, SULFATE ION | 著者 | Padmanabhan, B, Arole, A, Deshmukh, P, Ashok, S, Mathur, S. | 登録日 | 2021-10-25 | 公開日 | 2023-02-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family. Acta Crystallogr D Struct Biol, 79, 2023
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1BFN
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![BU of 1bfn by Molmil](/molmil-images/mine/1bfn) | BETA-AMYLASE/BETA-CYCLODEXTRIN COMPLEX | 分子名称: | BETA-AMYLASE, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), SULFATE ION | 著者 | Adachi, M, Mikami, B, Katsube, T, Utsumi, S. | 登録日 | 1998-05-22 | 公開日 | 1998-10-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Crystal structure of recombinant soybean beta-amylase complexed with beta-cyclodextrin. J.Biol.Chem., 273, 1998
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4PX1
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![BU of 4px1 by Molmil](/molmil-images/mine/4px1) | CRYSTAL STRUCTURE OF Maleylacetoacetate isomerase from Methylobacteriu extorquens AM1 WITH BOUND MALONATE (TARGET EFI-507068) | 分子名称: | CHLORIDE ION, MALONIC ACID, Maleylacetoacetate isomerase (Glutathione S-transferase) | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Imker, H.J, Al Obaidi, N, Stead, M, Love, J, Gerlt, J.A, Armstrong, R.N, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2014-03-21 | 公開日 | 2014-04-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of glutathione s-transferase zeta from methylobacterium extorquens (TARGET EFI-507068) To be Published
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7T18
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![BU of 7t18 by Molmil](/molmil-images/mine/7t18) | Rev1 Ternary Complex with dTTP and Ca2+ | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*G)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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6M8C
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7T1A
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![BU of 7t1a by Molmil](/molmil-images/mine/7t1a) | Rev1 Ternary Complex with dATP and Ca2+ | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | 著者 | Freudenthal, B.D, Weaver, T.M. | 登録日 | 2021-12-01 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nat Commun, 13, 2022
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4HX6
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![BU of 4hx6 by Molmil](/molmil-images/mine/4hx6) | Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6 | 分子名称: | ACETATE ION, Oxidoreductase, SULFATE ION | 著者 | Tan, K, Bigelow, L, Clancy, S, Babnigg, G, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2012-11-09 | 公開日 | 2012-11-28 | 最終更新日 | 2016-12-07 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry, 55, 2016
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1BGE
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6YAE
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![BU of 6yae by Molmil](/molmil-images/mine/6yae) | AP2 core in physiological buffer | 分子名称: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | 著者 | Kane Dickson, V, Kovtun, O, Kelly, B.T, Owen, D.J, Briggs, J.A.G. | 登録日 | 2020-03-12 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Sci Adv, 6, 2020
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4WRE
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![BU of 4wre by Molmil](/molmil-images/mine/4wre) | Crystal Structure of Surfactant Protein-A DEDN Mutant (E171D/P175E/R197N/K203D) Complexed with Inositol | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, CALCIUM ION, CHLORIDE ION, ... | 著者 | Rynkiewicz, M.J, Wu, H, Cafarella, T.R, Nikolaidis, N.M, Head, J.F, Seaton, B.A, McCormack, F.X. | 登録日 | 2014-10-23 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | 主引用文献 | Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop To be published
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6EZW
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![BU of 6ezw by Molmil](/molmil-images/mine/6ezw) | Crystal structure of a llama VHH antibody BCD090-M2 against human ErbB3 in space group C2 | 分子名称: | VHH antibody BCD090-M2 | 著者 | Eliseev, I.E, Yudenko, A.N, Vysochinskaya, V.V, Svirina, A.A, Evstratyeva, A.V, Drozhzhachih, M.S, Krendeleva, E.A, Vladimirova, A.K, Nemankin, T.A, Ekimova, V.M, Ulitin, A.B, Lomovskaya, M.I, Yakovlev, P.A, Moiseenko, F.V, Chakchir, O.B. | 登録日 | 2017-11-16 | 公開日 | 2017-11-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.59842849 Å) | 主引用文献 | Crystal structures of a llama VHH antibody BCD090-M2 targeting human ErbB3 receptor. F1000Res, 7, 2018
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5EP4
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![BU of 5ep4 by Molmil](/molmil-images/mine/5ep4) | Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Shah, T, Selcuk, H.B, Jeffrey, P.D, Hughson, F.M. | 登録日 | 2015-11-11 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. Plos Biol., 14, 2016
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4HXF
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![BU of 4hxf by Molmil](/molmil-images/mine/4hxf) | Acylaminoacyl peptidase in complex with Z-Gly-Gly-Phe-chloromethyl ketone | 分子名称: | CHLORIDE ION, HEXANE-1,6-DIOL, MAGNESIUM ION, ... | 著者 | Kiss-Szeman, A, Menyhard, D.K, Tichy-Racs, E, Hornung, B, Radi, K, Szeltner, Z, Domokos, K, Szamosi, I, Naray-Szabo, G, Polgar, L, Harmat, V. | 登録日 | 2012-11-09 | 公開日 | 2013-05-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION. J.Biol.Chem., 288, 2013
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6F0F
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![BU of 6f0f by Molmil](/molmil-images/mine/6f0f) | Crystal structure ASF1-ip2_s | 分子名称: | Histone chaperone ASF1A, ip2_s | 著者 | Gaubert, A, Guichard, B, Murciano, B, Le Du, M.H, Ochsenbein, F, Guerois, R, Andreani, J. | 登録日 | 2017-11-20 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chem Biol, 26, 2019
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