4WNO
Structure of ULK1 bound to an inhibitor
Summary for 4WNO
| Entry DOI | 10.2210/pdb4wno/pdb |
| Related | 4WNP |
| Descriptor | Serine/threonine-protein kinase ULK1, N~2~-(4-aminophenyl)-N~4~-(5-cyclopropyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine (3 entities in total) |
| Functional Keywords | kinase, autophagy, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytosol : O75385 |
| Total number of polymer chains | 1 |
| Total formula weight | 32677.67 |
| Authors | Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. (deposition date: 2014-10-14, release date: 2015-01-14, Last modification date: 2023-09-27) |
| Primary citation | Lazarus, M.B.,Novotny, C.J.,Shokat, K.M. Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. Acs Chem.Biol., 10:257-261, 2015 Cited by PubMed: 25551253DOI: 10.1021/cb500835z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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