4WNO

Structure of ULK1 bound to an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0010506	biological_process	regulation of autophagy

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 3RF A 401

Chain	Residue
A	ILE22
A	LEU145
A	ASP165
A	HOH540
A	HOH553
A	VAL30
A	ALA44
A	GLU93
A	TYR94
A	CYS95
A	GLY98
A	ASP102
A	HIS105

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGHGAFAVVFkGrhraahdle.........VAVK

Chain	Residue	Details
A	ILE22-LYS46

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpqNILL

Chain	Residue	Details
A	ILE134-LEU146

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP138

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE22

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:20921139

Chain	Residue	Details
A	LYS46

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O70405

Chain	Residue	Details
A	LYS162

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