5V5H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5v5h by Molmil](/molmil-images/mine/5v5h) | |
5W23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5w23 by Molmil](/molmil-images/mine/5w23) | |
5LAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lay by Molmil](/molmil-images/mine/5lay) | Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g | 分子名称: | (3~{S},3'~{S},4'~{S},5'~{S})-4'-azanyl-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-[(3-ethoxyphenyl)methyl]-5'-methyl-spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ... | 著者 | Kessler, D, Gollner, A. | 登録日 | 2016-06-15 | 公開日 | 2016-11-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J. Med. Chem., 59, 2016
|
|
6CM4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cm4 by Molmil](/molmil-images/mine/6cm4) | Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone | 分子名称: | 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, D(2) dopamine receptor, endolysin chimera, ... | 著者 | Wang, S, Che, T, Levit, A, Shoichet, B.K, Wacker, D, Roth, B.L. | 登録日 | 2018-03-02 | 公開日 | 2018-03-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.867 Å) | 主引用文献 | Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature, 555, 2018
|
|
6X0Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x0q by Molmil](/molmil-images/mine/6x0q) | |
4R48
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r48 by Molmil](/molmil-images/mine/4r48) | Racemic crystal structure of a calcium-bound DNA four-way junction | 分子名称: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', CALCIUM ION, SODIUM ION | 著者 | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | 登録日 | 2014-08-19 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
|
|
6WUQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wuq by Molmil](/molmil-images/mine/6wuq) | Crystal structure of AjiA1 in apo form | 分子名称: | AjiA1, MAGNESIUM ION, ZINC ION | 著者 | Paiva, F.C.R, Chan, K, Leadlay, P, Dias, M.V.B. | 登録日 | 2020-05-05 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family Acta Crystallogr.,Sect.D, 76, 2020
|
|
6CNY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cny by Molmil](/molmil-images/mine/6cny) | 2.3 Angstrom Structure of Phosphodiesterase treated Vivid (complex with FMN) | 分子名称: | FLAVIN MONONUCLEOTIDE, Vivid PAS protein VVD | 著者 | Zoltowski, B.D, Shabalin, I.G, Kowiel, M, Porebski, P.J, Crane, B.R, Bilwes, A.M. | 登録日 | 2018-03-09 | 公開日 | 2018-03-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conformational switching in the fungal light sensor Vivid. Science, 316, 2007
|
|
3DD2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dd2 by Molmil](/molmil-images/mine/3dd2) | |
7KRA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7kra by Molmil](/molmil-images/mine/7kra) | Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | 著者 | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | 登録日 | 2020-11-19 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
|
|
5GL2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gl2 by Molmil](/molmil-images/mine/5gl2) | |
6CBV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cbv by Molmil](/molmil-images/mine/6cbv) | Crystal structure of BRIL bound to an affinity matured synthetic antibody. | 分子名称: | BRIL, FORMIC ACID, GLYCEROL, ... | 著者 | Mukherjee, S, Skrobek, B, Kossiakoff, A.A. | 登録日 | 2018-02-05 | 公開日 | 2019-02-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.872 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
|
|
6CCF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ccf by Molmil](/molmil-images/mine/6ccf) | Crystal Structure of the Human CAMKK1A in complex with Hesperadin | 分子名称: | 1,2-ETHANEDIOL, Calcium/calmodulin-dependent protein kinase kinase 1, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE, ... | 著者 | Santiago, A.S, Counago, R.M, dos Reis, C.V, Ramos, P.Z, Silva, P.N.B, Drewry, D, Elkins, J.M, Massirer, K.B, Arruda, P, Edwards, A.M, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-07 | 公開日 | 2018-03-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of the Human CAMKK1A in complex with Hesperadin To be Published
|
|
6TCJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6tcj by Molmil](/molmil-images/mine/6tcj) | |
8E37
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e37 by Molmil](/molmil-images/mine/8e37) | Structure of Campylobacter concisus wild-type SeMet PglC | 分子名称: | N,N'-diacetylbacilliosaminyl-1-phosphate transferase | 著者 | Vuksanovic, N, Ray, L.C, Imperiali, B, Allen, K.N. | 登録日 | 2022-08-16 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble. J.Biol.Chem., 299, 2023
|
|
3V0A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3v0a by Molmil](/molmil-images/mine/3v0a) | 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ... | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | 登録日 | 2011-12-07 | 公開日 | 2012-03-14 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science, 335, 2012
|
|
6CXX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cxx by Molmil](/molmil-images/mine/6cxx) | Horse liver E267H alcohol dehydrogenase complex with 3'-dephosphocoenzyme A | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Alcohol dehydrogenase E chain, ... | 著者 | Plapp, B.V. | 登録日 | 2018-04-04 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Substitutions of a buried glutamate residue hinder the conformational change in horse liver alcohol dehydrogenase and yield a surprising complex with endogenous 3'-Dephosphocoenzyme A. Arch. Biochem. Biophys., 653, 2018
|
|
4R06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r06 by Molmil](/molmil-images/mine/4r06) | Crystal Structure of SR2067 bound to PPARgamma | 分子名称: | 1-(naphthalen-1-ylsulfonyl)-N-[(1S)-1-phenylpropyl]-1H-indole-5-carboxamide, Peroxisome proliferator-activated receptor gamma, SULFATE ION | 著者 | Marrewijk, L, Kamenecka, T, Griffin, P.R, Bruning, J.B. | 登録日 | 2014-07-30 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | SR2067 Reveals a Unique Kinetic and Structural Signature for PPAR gamma Partial Agonism. Acs Chem.Biol., 11, 2016
|
|
6CSM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6csm by Molmil](/molmil-images/mine/6csm) | Crystal structure of the natural light-gated anion channel GtACR1 | 分子名称: | GtACR1, OLEIC ACID, RETINAL | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | 登録日 | 2018-03-21 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature, 561, 2018
|
|
5GNH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gnh by Molmil](/molmil-images/mine/5gnh) | |
6CZY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6czy by Molmil](/molmil-images/mine/6czy) | Crystal structure of Arabidopsis thaliana phosphoserine aminotransferase isoform 1 (AtPSAT1) in complex with Pyridoxamine-5'-phosphate (PMP) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Sekula, B, Ruszkowski, M, Dauter, Z. | 登録日 | 2018-04-09 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) FromArabidopsis thaliana- the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis. Front Plant Sci, 9, 2018
|
|
6E8R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e8r by Molmil](/molmil-images/mine/6e8r) | |
8DTS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8dts by Molmil](/molmil-images/mine/8dts) | |
4S2L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4s2l by Molmil](/molmil-images/mine/4s2l) | Crystal Structure of OXA-163 beta-lactamase | 分子名称: | Beta-lactamase, SODIUM ION | 著者 | Stojanoski, V, Liya, H, Palzkill, T.G, Prasad, B, Sankaran, B. | 登録日 | 2015-01-21 | 公開日 | 2015-07-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structural Basis for Different Substrate Profiles of Two Closely Related Class D beta-Lactamases and Their Inhibition by Halogens. Biochemistry, 54, 2015
|
|
3HJK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hjk by Molmil](/molmil-images/mine/3hjk) | |