5V5H
 
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5W23
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5LAY
 | | Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g | | 分子名称: | (3~{S},3'~{S},4'~{S},5'~{S})-4'-azanyl-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-[(3-ethoxyphenyl)methyl]-5'-methyl-spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ... | | 著者 | Kessler, D, Gollner, A. | | 登録日 | 2016-06-15 | | 公開日 | 2016-11-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
J. Med. Chem., 59, 2016
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6CM4
 | | Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone | | 分子名称: | 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, D(2) dopamine receptor, endolysin chimera, ... | | 著者 | Wang, S, Che, T, Levit, A, Shoichet, B.K, Wacker, D, Roth, B.L. | | 登録日 | 2018-03-02 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.867 Å) | | 主引用文献 | Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.
Nature, 555, 2018
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6X0Q
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4R48
 | | Racemic crystal structure of a calcium-bound DNA four-way junction | | 分子名称: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', CALCIUM ION, SODIUM ION | | 著者 | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | | 登録日 | 2014-08-19 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Racemic DNA crystallography.
Angew.Chem.Int.Ed.Engl., 53, 2014
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6WUQ
 | | Crystal structure of AjiA1 in apo form | | 分子名称: | AjiA1, MAGNESIUM ION, ZINC ION | | 著者 | Paiva, F.C.R, Chan, K, Leadlay, P, Dias, M.V.B. | | 登録日 | 2020-05-05 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family
Acta Crystallogr.,Sect.D, 76, 2020
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6CNY
 | | 2.3 Angstrom Structure of Phosphodiesterase treated Vivid (complex with FMN) | | 分子名称: | FLAVIN MONONUCLEOTIDE, Vivid PAS protein VVD | | 著者 | Zoltowski, B.D, Shabalin, I.G, Kowiel, M, Porebski, P.J, Crane, B.R, Bilwes, A.M. | | 登録日 | 2018-03-09 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Conformational switching in the fungal light sensor Vivid.
Science, 316, 2007
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3DD2
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7KRA
 | | Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | | 著者 | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | | 登録日 | 2020-11-19 | | 公開日 | 2020-12-02 | | 最終更新日 | 2020-12-09 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
Elife, 9, 2020
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5GL2
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6CBV
 | | Crystal structure of BRIL bound to an affinity matured synthetic antibody. | | 分子名称: | BRIL, FORMIC ACID, GLYCEROL, ... | | 著者 | Mukherjee, S, Skrobek, B, Kossiakoff, A.A. | | 登録日 | 2018-02-05 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.872 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6CCF
 | | Crystal Structure of the Human CAMKK1A in complex with Hesperadin | | 分子名称: | 1,2-ETHANEDIOL, Calcium/calmodulin-dependent protein kinase kinase 1, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE, ... | | 著者 | Santiago, A.S, Counago, R.M, dos Reis, C.V, Ramos, P.Z, Silva, P.N.B, Drewry, D, Elkins, J.M, Massirer, K.B, Arruda, P, Edwards, A.M, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-07 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of the Human CAMKK1A in complex with Hesperadin
To be Published
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6TCJ
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8E37
 | | Structure of Campylobacter concisus wild-type SeMet PglC | | 分子名称: | N,N'-diacetylbacilliosaminyl-1-phosphate transferase | | 著者 | Vuksanovic, N, Ray, L.C, Imperiali, B, Allen, K.N. | | 登録日 | 2022-08-16 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble.
J.Biol.Chem., 299, 2023
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3V0A
 | | 2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BoNT/A, CALCIUM ION, ... | | 著者 | Gu, S, Rumpel, S, Zhou, J, Strotmeier, J, Bigalke, H, Perry, K, Shoemaker, C.B, Rummel, A, Jin, R. | | 登録日 | 2011-12-07 | | 公開日 | 2012-03-14 | | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | | 主引用文献 | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
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6CXX
 | | Horse liver E267H alcohol dehydrogenase complex with 3'-dephosphocoenzyme A | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, Alcohol dehydrogenase E chain, ... | | 著者 | Plapp, B.V. | | 登録日 | 2018-04-04 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | | 主引用文献 | Substitutions of a buried glutamate residue hinder the conformational change in horse liver alcohol dehydrogenase and yield a surprising complex with endogenous 3'-Dephosphocoenzyme A.
Arch. Biochem. Biophys., 653, 2018
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4R06
 | | Crystal Structure of SR2067 bound to PPARgamma | | 分子名称: | 1-(naphthalen-1-ylsulfonyl)-N-[(1S)-1-phenylpropyl]-1H-indole-5-carboxamide, Peroxisome proliferator-activated receptor gamma, SULFATE ION | | 著者 | Marrewijk, L, Kamenecka, T, Griffin, P.R, Bruning, J.B. | | 登録日 | 2014-07-30 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | SR2067 Reveals a Unique Kinetic and Structural Signature for PPAR gamma Partial Agonism.
Acs Chem.Biol., 11, 2016
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6CSM
 | | Crystal structure of the natural light-gated anion channel GtACR1 | | 分子名称: | GtACR1, OLEIC ACID, RETINAL | | 著者 | Kato, H.E, Kim, Y, Yamashita, K, Kobilka, B.K, Deisseroth, K. | | 登録日 | 2018-03-21 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Nature, 561, 2018
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5GNH
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6CZY
 | | Crystal structure of Arabidopsis thaliana phosphoserine aminotransferase isoform 1 (AtPSAT1) in complex with Pyridoxamine-5'-phosphate (PMP) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sekula, B, Ruszkowski, M, Dauter, Z. | | 登録日 | 2018-04-09 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) FromArabidopsis thaliana- the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis.
Front Plant Sci, 9, 2018
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6E8R
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8DTS
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4S2L
 | | Crystal Structure of OXA-163 beta-lactamase | | 分子名称: | Beta-lactamase, SODIUM ION | | 著者 | Stojanoski, V, Liya, H, Palzkill, T.G, Prasad, B, Sankaran, B. | | 登録日 | 2015-01-21 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structural Basis for Different Substrate Profiles of Two Closely Related Class D beta-Lactamases and Their Inhibition by Halogens.
Biochemistry, 54, 2015
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3HJK
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