4R06
Crystal Structure of SR2067 bound to PPARgamma
Summary for 4R06
Entry DOI | 10.2210/pdb4r06/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 1-(naphthalen-1-ylsulfonyl)-N-[(1S)-1-phenylpropyl]-1H-indole-5-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | nuclear receptor, ligand binding protein, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 62981.10 |
Authors | Marrewijk, L.,Kamenecka, T.,Griffin, P.R.,Bruning, J.B. (deposition date: 2014-07-30, release date: 2016-01-27, Last modification date: 2023-09-20) |
Primary citation | van Marrewijk, L.M.,Polyak, S.W.,Hijnen, M.,Kuruvilla, D.,Chang, M.R.,Shin, Y.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B. SR2067 Reveals a Unique Kinetic and Structural Signature for PPAR gamma Partial Agonism. Acs Chem.Biol., 11:273-283, 2016 Cited by PubMed: 26579553DOI: 10.1021/acschembio.5b00580 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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