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4R06

Crystal Structure of SR2067 bound to PPARgamma

Summary for 4R06
Entry DOI10.2210/pdb4r06/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, 1-(naphthalen-1-ylsulfonyl)-N-[(1S)-1-phenylpropyl]-1H-indole-5-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsnuclear receptor, ligand binding protein, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight62981.10
Authors
Marrewijk, L.,Kamenecka, T.,Griffin, P.R.,Bruning, J.B. (deposition date: 2014-07-30, release date: 2016-01-27, Last modification date: 2023-09-20)
Primary citationvan Marrewijk, L.M.,Polyak, S.W.,Hijnen, M.,Kuruvilla, D.,Chang, M.R.,Shin, Y.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B.
SR2067 Reveals a Unique Kinetic and Structural Signature for PPAR gamma Partial Agonism.
Acs Chem.Biol., 11:273-283, 2016
Cited by
PubMed: 26579553
DOI: 10.1021/acschembio.5b00580
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.22 Å)
Structure validation

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