PDB: 37273 件ウェブページステータス検索Chemie searchBIRD

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3P8F	Crystal Structure of MT-SP1 in complex with SFTI-1 分子名称: GLUTATHIONE, ST14 protein, Trypsin inhibitor 1 著者 Yuan, C, Huang, M, Chen, L. 登録日 2010-10-13 公開日 2011-08-10 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1. Bmc Struct.Biol., 11, 2011
3OK9	Crystal structure of wild-type HIV-1 protease with new oxatricyclic designed inhibitor GRL-0519A 分子名称: (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, GLYCEROL, ... 著者 Wang, Y.-F, Agniswamy, J, Weber, I.T. 登録日 2010-08-24 公開日 2010-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors. Chemmedchem, 5, 2010
4EK1	Crystal Structure of Electron-Spin Labeled Cytochrome P450cam 分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Lee, Y.-T, Goodin, D.B. 登録日 2012-04-08 公開日 2012-07-25 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Double electron-electron resonance shows cytochrome P450cam undergoes a conformational change in solution upon binding substrate. Proc.Natl.Acad.Sci.USA, 109, 2012
4AHG	S28N - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis 分子名称: ANGIOGENIN, D(-)-TARTARIC ACID 著者 Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. 登録日 2012-02-06 公開日 2012-10-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.448 Å) 主引用文献 Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons. Nat.Commun., 3, 2012
4ABA	Fragments bound to bovine trypsin for the SAMPL challenge 分子名称: 1,2-ETHANEDIOL, 1-[2-(thiophen-2-yl)-1,3-thiazol-4-yl]methanamine, CALCIUM ION, ... 著者 Newman, J, Peat, T.S. 登録日 2011-12-08 公開日 2012-02-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 The Dingo Dataset: A Comprehensive Set of Data for the Sampl Challenge. J.Comput.Aided Mol.Des., 26, 2012
3GI4	Crystal structure of protease inhibitor, KB60 in complex with wild type HIV-1 protease 分子名称: 5S)-N-[(1S,2R)-3-[(1,3-Benzodioxol-5-ylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-2-oxo-3-[3-(tr ifluoromethyl)phenyl]-5-oxazolidinecarboxamide, ACETATE ION, PHOSPHATE ION, ... 著者 Nalam, M.N.L, Schiffer, C.A. 登録日 2009-03-05 公開日 2010-03-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J.Virol., 84, 2010
3GCT	STRUCTURE OF GAMMA-*CHYMOTRYPSIN IN THE RANGE $P*H 2.0 TO $P*H 10.5 SUGGESTS THAT GAMMA-CHYMOTRYPSIN IS A COVALENT ACYL-ENZYME ADDUCT AT LOW $P*H 分子名称: GAMMA-CHYMOTRYPSIN A, SULFATE ION, UNK PRO GLY ALA TYR PEPTIDE 著者 Dixon, M.M, Matthews, B.W. 登録日 1990-09-04 公開日 1991-10-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH. Int.J.Biol.Macromol., 13, 1991
3GBQ	SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, MINIMIZED AVERAGE STRUCTURE 分子名称: GRB2, SOS-1 著者 Wittekind, M, Mapelli, C, Lee, V, Goldfarb, V, Friedrichs, M.S, Meyers, C.A, Mueller, L. 登録日 1996-12-23 公開日 1997-09-04 最終更新日 2024-10-09 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts. J.Mol.Biol., 267, 1997
3GCH	CHEMISTRY OF CAGED ENZYMES. BINDING OF PHOTOREVERSIBLE CINNAMATES TO CHYMOTRYPSIN 分子名称: GAMMA-CHYMOTRYPSIN, TRANS-O-HYDROXY-ALPHA-METHYL CINNAMATE 著者 Stoddard, B.L, Ringe, D, Petsko, G.A. 登録日 1989-09-25 公開日 1990-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and activity of two photoreversible cinnamates bound to chymotrypsin. Biochemistry, 29, 1990
3GF1	SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY 分子名称: INSULIN-LIKE GROWTH FACTOR I 著者 Cooke, R.M, Harvey, T.S, Campbell, I.D. 登録日 1991-01-24 公開日 1993-04-15 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry, 30, 1991
3WH3	human Mincle, ligand free form 分子名称: C-type lectin domain family 4 member E, CALCIUM ION 著者 Furukawa, A, Kamishikiryo, J, Mori, D, Toyonaga, K, Okabe, Y, Toji, A, Kanda, R, Miyake, Y, Ose, T, Yamasaki, S, Maenaka, K. 登録日 2013-08-21 公開日 2013-10-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL Proc.Natl.Acad.Sci.USA, 110, 2013
4EGL	Crystal structure of two tandem RNA recognition motifs of Human antigen R 分子名称: ELAV-like protein 1, GLYCEROL, SULFATE ION 著者 Wang, H, Zeng, F, Liu, H, Teng, M, Li, X. 登録日 2012-03-31 公開日 2012-05-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of two tandem RNA recognition motifs of Human antigen R To be Published
3WBG	Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid 分子名称: 8-ANILINO-1-NAPHTHALENE SULFONATE, Fatty acid-binding protein, heart 著者 Hirose, M, Sugiyama, S, Ishida, H, Niiyama, M, Matsuoka, D, Hara, T, Sato, F, Mizohata, E, Murakami, S, Inoue, T, Matsuoka, S, Murata, M. 登録日 2013-05-16 公開日 2013-10-30 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure of the human-heart fatty-acid-binding protein 3 in complex with the fluorescent probe 1-anilinonaphthalene-8-sulphonic acid J.SYNCHROTRON RADIAT., 20, 2013
4EPR	Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Sun, Q, Burke, J.P, Phan, J, Burns, M.C, Olejniczak, E.T, Waterson, A.G, Lee, T, Rossanese, O.W, Fesik, S.W. 登録日 2012-04-17 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew.Chem.Int.Ed.Engl., 51, 2012
3OOT	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes 分子名称: 2-(3-fluoro-2-methylbenzyl)-4-methyl-1-phenyl-3-(piperazin-1-ylcarbonyl)-1H-indol-5-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin 著者 Bocskei, Z. 登録日 2010-08-31 公開日 2010-10-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
4EPW	Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation 分子名称: (4-hydroxypiperidin-1-yl)(1H-indol-3-yl)methanethione, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sun, Q, Burke, J.P, Phan, J, Burns, M.C, Olejniczak, E.T, Waterson, A.G, Lee, T, Rossanese, O.W, Fesik, S.W. 登録日 2012-04-17 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew.Chem.Int.Ed.Engl., 51, 2012
4ER2	The active site of aspartic proteinases 分子名称: ENDOTHIAPEPSIN, PEPSTATIN, SULFATE ION 著者 Bailey, D, Veerapandian, B, Cooper, J.B, Blundell, T.L. 登録日 1990-10-20 公開日 1991-01-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The active site of aspartic proteinases FEBS Lett., 174, 1984
4J5J	Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir 分子名称: CHLORIDE ION, Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER 著者 Shen, C.H, Weber, I.T. 登録日 2013-02-08 公開日 2013-05-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1'-Pyrrolidinone or P2-Tris-tetrahydrofuran. J.Med.Chem., 56, 2013
3WR1	Crystal structure of Cormorant (Phalacrocorax carbo) hemoglobin 分子名称: Hemoglobin subunit alpha-A, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE 著者 Jagadeesan, G, Vinodh Kumar, V, Peters, H.G, Malathy, P, Harikrishna Etti, S, Gunasekaran, K, Aravindhan, S. 登録日 2014-02-09 公開日 2014-03-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Crystal structure of Cormorant (Phalacrocorax carbo) hemoglobin To be Published
4EJK	HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap 分子名称: INDOLYLPROPIONIC ACID, Protease, pepstatin 著者 Tiefenbrunn, T, Stout, C.D. 登録日 2012-04-06 公開日 2013-05-01 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (1.794 Å) 主引用文献 Small molecule regulation of protein conformation by binding in the Flap of HIV protease. Acs Chem.Biol., 8, 2013
4EWO	Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors 分子名称: Beta-secretase 1, N-[(2S,3R)-4-{[(4S)-2-(2,2-dimethylpropyl)-6,6-dimethyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]amino}-3-hydroxy-1-phenylbutan-2-yl]acetamide 著者 Borkakoti, N, Lindberg, J, Derbyshire, D. 登録日 2012-04-27 公開日 2012-10-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates. Bioorg.Med.Chem.Lett., 22, 2012
4J60	Crystal structure of Ribonuclease A soaked in 25% Cyclopentanol: One of twelve in MSCS set 分子名称: Ribonuclease pancreatic, SULFATE ION, cyclopentanol 著者 Kearney, B.M, Dechene, M, Swartz, P.D, Mattos, C. 登録日 2013-02-11 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 DRoP: A program for analysis of water structure on protein surfaces to be published
4EWZ	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-04-29 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.791 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
3WRL	Crystal structure of P450cam 分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Kishimoto, A, Takagi, K, Amano, A, Sakurai, K, Mizushima, T, Shimada, H. 登録日 2014-02-25 公開日 2015-03-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure of P450cam intermedite To be published
4J64	Crystal structure of Ribonuclease A soaked in 40% Dioxane: One of twelve in MSCS set 分子名称: 1,4-DIETHYLENE DIOXIDE, Ribonuclease pancreatic, SULFATE ION 著者 Kearney, B.M, Dechene, M, Swartz, P.D, Mattos, C. 登録日 2013-02-11 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.781 Å) 主引用文献 DRoP: A program for analysis of water structure on protein surfaces to be published

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