PDB: 161 件ウェブページステータス検索Chemie searchBIRD

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7EDR	The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin 分子名称: Moesin/ezrin/radixin homolog 2 著者 Zhang, F, Long, J, Zhou, H. 登録日 2021-03-16 公開日 2021-04-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.527 Å) 主引用文献 The crystal structure of the FERM and C-terminal domain complex of Drosophila Merlin. Biochem.Biophys.Res.Commun., 553, 2021
7LWH	Human neurofibromin 2/merlin residues 1-339 in complex with LATS1 分子名称: GLYCEROL, IMIDAZOLE, Merlin, ... 著者 Primi, M.C, Rangarajan, E.S, Izard, T. 登録日 2021-03-01 公開日 2021-08-11 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.606 Å) 主引用文献 Conformational flexibility determines the Nf2/merlin tumor suppressor functions. Matrix Biol Plus, 12, 2021
8CIR	The FERM domain of human moesin with a bound peptide identified by phage display 分子名称: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... 著者 Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. 登録日 2023-02-10 公開日 2023-03-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8CIS	The FERM domain of human moesin with two bound peptides identified by phage display 分子名称: 1,2-ETHANEDIOL, ACETATE ION, C3P, ... 著者 Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. 登録日 2023-02-10 公開日 2023-03-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8CIT	The FERM domain of human moesin mutant L281R 分子名称: Moesin 著者 Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. 登録日 2023-02-10 公開日 2023-03-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.536 Å) 主引用文献 Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8CIU	The FERM domain of human moesin mutant H288A 分子名称: Moesin 著者 Bradshaw, W.J, Katis, V.L, Koekemoer, L, Bountra, C, von Delft, F, Brennan, P.E. 登録日 2023-02-10 公開日 2023-03-01 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.393 Å) 主引用文献 Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease. J.Biol.Chem., 299, 2023
8GVL	PTPN21 FERM 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21 著者 Chen, L, Zheng, Y.Y, Zhou, C. 登録日 2022-09-15 公開日 2023-09-20 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
8GXE	PTPN21 FERM PTP complex 分子名称: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 著者 Chen, L, Zheng, Y.Y, Zhou, C. 登録日 2022-09-19 公開日 2023-09-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
8SU8	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde). 分子名称: (6P)-6-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Bruystens, J.G.H. 登録日 2023-05-11 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8T09	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde) 分子名称: 6-ethynyl-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Bruystens, J.G.H. 登録日 2023-05-31 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023
8T7V	Co-crystal structure of KRIT1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde) 分子名称: (7M)-7-(furan-2-yl)-2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Bruystens, J.G.H. 登録日 2023-06-21 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors. Acs Pharmacol Transl Sci, 6, 2023

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