6QHM
| 14-3-3 sigma with RelA/p65 binding site pS281 | 分子名称: | 14-3-3 protein sigma, LEU-SEP-GLU | 著者 | Wolter, M, Ottmann, C. | 登録日 | 2019-01-16 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
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6QIU
| Crystal structure of 14-3-3 sigma in complex with Ataxin-1 Ser776 phosphopeptide | 分子名称: | 14-3-3 protein sigma, Ataxin-1 phosphopeptide, CHLORIDE ION, ... | 著者 | Leysen, S, Milroy, L.G, Davis, J.M, Brunsveld, L, Ottmann, C. | 登録日 | 2019-01-21 | 公開日 | 2020-05-13 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Structural insights into the cytoplasmic chaperone effect of 14-3-3 proteins on Ataxin-1 To Be Published
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6QDT
| Crystal structure of 14-3-3sigma in complex with a RapGef2 pT740 phosphopeptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. | 登録日 | 2019-01-02 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
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6QHL
| 14-3-3 sigma with RelA/p65 binding site pS45 | 分子名称: | 14-3-3 protein sigma, GLYCEROL, Transcription factor p65 | 著者 | Wolter, M, Ottmann, C. | 登録日 | 2019-01-16 | 公開日 | 2020-05-13 | 最終更新日 | 2020-12-30 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
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6QDS
| Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide stabilized by semi-synthetic fusicoccane FC-NCPC | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, FC-NCPC, ... | 著者 | Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. | 登録日 | 2019-01-02 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
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6QDR
| Crystal structure of 14-3-3sigma in complex with a PAK6 pT99 phosphopeptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Andrei, S.A, Kaplan, A, Fournier, A.E, Ottman, C. | 登録日 | 2019-01-02 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.615 Å) | 主引用文献 | Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth. Cell Chem Biol, 27, 2020
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6QZR
| 14-3-3 sigma in complex with FOXO1 pT24 peptide | 分子名称: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Forkhead box protein O1, ... | 著者 | Ottmann, C, Wolter, M, Lau, R.A. | 登録日 | 2019-03-12 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
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6QZS
| 14-3-3 sigma in complex with FOXO1 pS256 peptide | 分子名称: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ... | 著者 | Ottmann, C, Wolter, M, Lau, R.A. | 登録日 | 2019-03-12 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
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4DHR
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(2-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DAU
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4DHM
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHT
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 PROTEIN SIGMA, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DX0
| Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative | 分子名称: | 14-3-3-like protein E, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA | 著者 | Richter, A, Rose, R, Hedberg, C, Waldmann, H, Ottmann, C. | 登録日 | 2012-02-27 | 公開日 | 2012-05-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction. Chemistry, 18, 2012
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4BG6
| 14-3-3 interaction with Rnd3 prenyl-phosphorylation motif | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, FARNESYL, ... | 著者 | Riou, P, Kjaer, S, Purkiss, A, O'Reilly, N, McDonald, N.Q. | 登録日 | 2013-03-23 | 公開日 | 2013-05-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins. Cell(Cambridge,Mass.), 153, 2013
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4DHP
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4E2E
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4DAT
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4DNK
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4DHS
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(3,5-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHN
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHQ
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(3-chlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHO
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(3-methoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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4DHU
| Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening | 分子名称: | (2-{2-[(2,3-dichlorophenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 PROTEIN SIGMA, CHLORIDE ION, ... | 著者 | Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. | 登録日 | 2012-01-30 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
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6ZFD
| 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, GLYCEROL | 著者 | Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. | 登録日 | 2020-06-17 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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6ZFG
| 14-3-3 zeta chimera with 18E6 and fusicoccin | 分子名称: | 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL | 著者 | Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. | 登録日 | 2020-06-17 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
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