6SI3
 
 | | p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301 | | 分子名称: | 1,2-ETHANEDIOL, 1-[7-bromanyl-9-[2,2,2-tris(fluoranyl)ethyl]carbazol-3-yl]-~{N}-methyl-methanamine, Cellular tumor antigen p53, ... | | 著者 | Joerger, A.C, Bauer, M.R, Structural Genomics Consortium (SGC) | | 登録日 | 2019-08-08 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
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5MQQ
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8FYH
 | | G4 RNA-mediated PRC2 dimer | | 分子名称: | G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... | | 著者 | Song, J, Kasinath, V. | | 登録日 | 2023-01-26 | | 公開日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Science, 381, 2023
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6SI1
 | | p53 cancer mutant Y220H | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cellular tumor antigen p53, ... | | 著者 | Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2019-08-08 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
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5H1A
 | | Crystal structure of an IclR homolog from Microbacterium sp. strain HM58-2 | | 分子名称: | IclR transcription factor homolog, PHOSPHATE ION | | 著者 | Akiyama, T, Yamada, Y, Takaya, N, Ito, S, Sasaki, Y, Yajima, S. | | 登録日 | 2016-10-08 | | 公開日 | 2017-01-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of an IclR homologue from Microbacterium sp. strain HM58-2.
Acta Crystallogr F Struct Biol Commun, 73, 2017
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2NVT
 | | RNA Polymerase II Elongation Complex in 150 mM Mg+2 with GMPCPP | | 分子名称: | 5'-D(*GP*TP*AP*CP*TP*TP*G)-3', 5'-D(P*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-13 | | 公開日 | 2006-12-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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2NVZ
 | | RNA Polymerase II elongation complex with UTP, updated 11/2006 | | 分子名称: | 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-14 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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6NQ3
 | | Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex | | 分子名称: | Histone-binding protein RBBP4, PHD finger protein 19, Polycomb protein SUZ12, ... | | 著者 | Chen, S, Jiao, L, Liu, X. | | 登録日 | 2019-01-19 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
Mol.Cell, 77, 2020
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6QJX
 | | TetR(D) T103A mutant in complex with minocycline and magnesium | | 分子名称: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | | 登録日 | 2019-01-27 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
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2NVX
 | | RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dUTP | | 分子名称: | 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-13 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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3CQZ
 | | Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin | | 分子名称: | ALPHA-AMANITIN, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... | | 著者 | Kaplan, C.D, Larsson, K.-M, Kornberg, R.D. | | 登録日 | 2008-04-03 | | 公開日 | 2008-07-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
Mol.Cell, 30, 2008
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6QJW
 | | TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium | | 分子名称: | 7-CHLOROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | | 登録日 | 2019-01-27 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
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2HH7
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2NVQ
 | | RNA Polymerase II Elongation Complex in 150 mM Mg+2 with 2'dUTP | | 分子名称: | 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ... | | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | | 登録日 | 2006-11-13 | | 公開日 | 2006-12-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
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3OYG
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI Compound1 (CompoundG) | | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-6-methyl-4-(5-methyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione, AMMONIUM ION, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), ... | | 著者 | Hare, S, Cherepanov, P. | | 登録日 | 2010-09-23 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3OYF
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI L-870,810 | | 分子名称: | 5-(1,1-dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide, AMMONIUM ION, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), ... | | 著者 | Hare, S, Cherepanov, P. | | 登録日 | 2010-09-23 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3OYB
 | | Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI MK2048 | | 分子名称: | (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, AMMONIUM ION, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), ... | | 著者 | Hare, S, Cherepanov, P. | | 登録日 | 2010-09-23 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3OYI
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5N2O
 | | Structure Of P63 SAM Domain L514F Mutant Causative Of AEC Syndrome | | 分子名称: | Tumor protein 63 | | 著者 | Rinnenthal, J, Wuerz, J.M, Osterburg, C, Guentert, P, Doetsch, V. | | 登録日 | 2017-02-08 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2VPR
 | | Tet repressor class H in complex with 5a,6- anhydrotetracycline-Mg | | 分子名称: | 5A,6-ANHYDROTETRACYCLINE, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Schuldt, L, Palm, G, Hinrichs, W. | | 登録日 | 2008-03-03 | | 公開日 | 2008-03-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Tet Repressor Induction by Tetracycline: A Molecular Dynamics, Continuum Electrostatics, and Crystallographic Study
J.Mol.Biol., 378, 2008
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3OYK
 | | Crystal structure of the PFV S217H mutant intasome bound to manganese | | 分子名称: | AMMONIUM ION, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... | | 著者 | Hare, S, Cherepanov, P. | | 登録日 | 2010-09-23 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1M06
 | | Structural Studies of Bacteriophage alpha3 Assembly, X-Ray Crystallography | | 分子名称: | 5'-D(P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR)P*(3DR))-3', Capsid Protein, Major spike protein, ... | | 著者 | Bernal, R.A, Hafenstein, S, Olson, N.H, Bowman, V, Chipman, P.R, Baker, T.S, Fane, B.A, Rossmann, M.G. | | 登録日 | 2002-06-12 | | 公開日 | 2002-12-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural Studies of Bacteriophage alpha3 Assembly
J.Mol.Biol., 325, 2003
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7M5M
 | | PCNA bound to peptide mimetic | | 分子名称: | N-BUTANE, Peptide mimetic (ACE)RQCSMTCFYHSK(NH2) with linker, Proliferating cell nuclear antigen | | 著者 | Vandborg, B.A, Bruning, J.B. | | 登録日 | 2021-03-24 | | 公開日 | 2021-08-11 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A cell permeable bimane-constrained PCNA-interacting peptide.
Rsc Chem Biol, 2, 2021
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7M5L
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7M5N
 | | PCNA bound to peptide mimetic with linker | | 分子名称: | 1,3-dimethylbenzene, Peptide mimetic (ACE)RQCSMTCFYHSK(NH2) with linker, Proliferating cell nuclear antigen | | 著者 | Vandborg, B.A, Bruning, J.B. | | 登録日 | 2021-03-24 | | 公開日 | 2021-08-11 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | A cell permeable bimane-constrained PCNA-interacting peptide.
Rsc Chem Biol, 2, 2021
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