1C6Q
 
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6EDX
 | | Crystal Structure of SGK3 PX domain | | 分子名称: | GLYCEROL, Serine/threonine-protein kinase Sgk3 | | 著者 | Chandra, M, Collins, B.M. | | 登録日 | 2018-08-12 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.009 Å) | | 主引用文献 | Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Nat Commun, 10, 2019
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1C6H
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2WLM
 | | POTASSIUM CHANNEL FROM MAGNETOSPIRILLUM MAGNETOTACTICUM | | 分子名称: | POTASSIUM CHANNEL, POTASSIUM ION | | 著者 | Clarke, O.B, Caputo, A.T, Smith, B.J, Gulbis, J.M. | | 登録日 | 2009-06-24 | | 公開日 | 2010-06-09 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | | 主引用文献 | Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels.
Cell(Cambridge,Mass.), 141, 2010
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5MLB
 | | Crystal structure of human RAS in complex with darpin K27 | | 分子名称: | DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2016-12-06 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
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5FDH
 | | CRYSTAL STRUCTURE OF OXA-405 BETA-LACTAMASE | | 分子名称: | Beta-lactamase, GLYCEROL, SULFATE ION | | 著者 | Retailleau, P, Oueslati, S, Marchini, L, Dortet, L, Naas, T, Iorga, B. | | 登録日 | 2015-12-16 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Biochemical and Structural Characterization of OXA-405, an OXA-48 Variant with Extended-Spectrum beta-Lactamase Activity.
Microorganisms, 8, 2019
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1CCJ
 | | CONFORMER SELECTION BY LIGAND BINDING OBSERVED WITH PROTEIN CRYSTALLOGRAPHY | | 分子名称: | CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Cao, Y, Musah, R.A, Wilcox, S.K, Goodin, D.B, Mcree, D.E. | | 登録日 | 1997-01-22 | | 公開日 | 1997-07-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Protein conformer selection by ligand binding observed with crystallography.
Protein Sci., 7, 1998
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1C6A
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6NZC
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4YUO
 | | High-resolution multiconformer synchrotron model of CypA at 273 K | | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | | 著者 | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | | 登録日 | 2015-03-18 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.
Elife, 4, 2015
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5M26
 | | Crystal structure of hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 in complex with methylhydroquinone | | 分子名称: | 2-methylbenzene-1,4-diol, FE (III) ION, Hydroquinone dioxygenase large subunit, ... | | 著者 | Ferraroni, M, Da Vela, S, Scozzafava, A, Kolvenbach, B, Corvini, P.F.X. | | 登録日 | 2016-10-12 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structures of native hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 and of substrate and inhibitor complexes.
Biochim. Biophys. Acta, 1865, 2017
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6O1E
 | | The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP | | 分子名称: | MAGNESIUM ION, MORC family CW-type zinc finger protein 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Klein, B.J, Zhang, Y, Kutateladze, T.G. | | 登録日 | 2019-02-19 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Mechanism for autoinhibition and activation of the MORC3 ATPase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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1BRY
 | | BRYODIN TYPE I RIP | | 分子名称: | BRYODIN I | | 著者 | Klei, H.E, Chang, C.Y. | | 登録日 | 1997-02-14 | | 公開日 | 1998-03-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica.
Biochemistry, 36, 1997
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4YUJ
 | | Multiconformer synchrotron model of CypA at 240 K | | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | | 著者 | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | | 登録日 | 2015-03-18 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.
Elife, 4, 2015
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6HQY
 | | Crystal structure of Schistosoma mansoni HDAC8 complexed with PCI-34051 | | 分子名称: | 1-[(4-methoxyphenyl)methyl]-~{N}-oxidanyl-indole-6-carboxamide, GLYCEROL, Histone deacetylase, ... | | 著者 | Marek, M, Shaik, T.B, Romier, C. | | 登録日 | 2018-09-25 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
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6G80
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5JZI
 | | Crystal structure of 1406 TCR bound to HLA-A2 with HCV 1406-1415 antigen peptide | | 分子名称: | Beta-2-microglobulin, HCV1406 TCR alpha chain, HCV1406 TCR beta chain, ... | | 著者 | Wang, Y, Piepenbrink, K.H, Baker, B.M. | | 登録日 | 2016-05-16 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | How an alloreactive T-cell receptor achieves peptide and MHC specificity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2OJ0
 | | Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site MN soaked | | 分子名称: | 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3', MANGANESE (II) ION, POTASSIUM ION, ... | | 著者 | Ennifar, E, Walter, P, Dumas, P. | | 登録日 | 2007-01-12 | | 公開日 | 2007-12-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Cation-dependent cleavage of the duplex form of the subtype-B HIV-1 RNA dimerization initiation site.
Nucleic Acids Res., 38, 2010
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1BLQ
 | | STRUCTURE AND INTERACTION SITE OF THE REGULATORY DOMAIN OF TROPONIN-C WHEN COMPLEXED WITH THE 96-148 REGION OF TROPONIN-I, NMR, 29 STRUCTURES | | 分子名称: | N-TROPONIN C | | 著者 | Mckay, R.T, Pearlstone, J.R, Corson, D.C, Gagne, S.M, Smillie, L.B, Sykes, B.D. | | 登録日 | 1998-07-19 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and interaction site of the regulatory domain of troponin-C when complexed with the 96-148 region of troponin-I.
Biochemistry, 37, 1998
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7BG4
 | | Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by Cryo-EM | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA, ... | | 著者 | Wiseman, B, Chaptal, V, Zampieri, V, Magnard, S, Hogbom, M, Falson, P. | | 登録日 | 2021-01-05 | | 公開日 | 2022-01-12 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
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6X3P
 | | Co-structure of BTK kinase domain with L-005298385 inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-{8-amino-3-[(6R,8aS)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(cyclopropyloxy)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide, ... | | 著者 | Fischmann, T.O. | | 登録日 | 2020-05-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Bioorg.Med.Chem.Lett., 30, 2020
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6CZG
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5M50
 | | Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins | | 分子名称: | Calmodulin-regulated spectrin-associated protein 3, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Akhmanova, A, Moores, C.A, Baldus, M, Steinmetz, M.O, Topf, M, Roberts, A.J, Grant, B.J, Scarabelli, G, Joseph, A.-P, van Hooff, J.J.E, Houben, K, Hua, S, Luo, Y, Stangier, M.M, Jiang, K, Atherton, J. | | 登録日 | 2016-10-20 | | 公開日 | 2017-10-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | | 主引用文献 | A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
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3HZG
 | | Crystal structure of mycobacterium tuberculosis thymidylate synthase X bound with FAD | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Staker, B.L, Rathod, P, Hunter, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2009-06-23 | | 公開日 | 2009-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
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5JTY
 | | Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007 | | 分子名称: | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, ... | | 著者 | Mou, T.-C, Sprang, S.R, Hansen, K.B. | | 登録日 | 2016-05-10 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
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