PDB: 2561 件ウェブページステータス検索Chemie searchBIRD

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6K39	Structural analysis of AIMP2-DX2 and HSP70 interaction 分子名称: Heat shock 70 kDa protein 1A,Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 著者 Cho, H.Y, Son, S.Y, Jeon, Y.H. 登録日 2019-05-16 公開日 2019-10-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.3981427 Å) 主引用文献 Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development. Nat.Chem.Biol., 16, 2020
6NU6	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5 分子名称: 4-[(1R,2S)-2-(carboxymethyl)cyclopentane-1-carbonyl]benzoic acid, 4-[(1S,2R)-2-(carboxymethyl)cyclopentane-1-carbonyl]benzoic acid, ATP-dependent dethiobiotin synthetase BioD, ... 著者 Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. 登録日 2019-01-31 公開日 2020-02-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.437 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5 To Be Published
6NWN	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with glutamic acid linked compound 10 分子名称: 5'-{[N-({(1S,2R)-2-[4-(carboxymethyl)benzene-1-carbonyl]cyclopentyl}acetyl)-L-gamma-glutamyl]amino}-2',5'-dideoxycytidine, ATP-dependent dethiobiotin synthetase BioD, CITRIC ACID 著者 Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. 登録日 2019-02-06 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.005 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with glutamic acid linked compound 10 To Be Published
6NVE	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 7 分子名称: 4-{[(1S,2S)-2-(carboxymethyl)cyclopentyl]methyl}benzoic acid, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION 著者 Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B. 登録日 2019-02-05 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 7 To Be Published
7QNZ	human Lig1-DNA-PCNA complex reconstituted in absence of ATP 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase 1, Oligo13P, ... 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2021-12-23 公開日 2023-01-11 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.58 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
4NM5	Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif 分子名称: ADENOSINE-5'-DIPHOSPHATE, Axin-1, CHLORIDE ION, ... 著者 Stamos, J.L, Chu, M.L.-H, Enos, M.D, Shah, N, Weis, W.I. 登録日 2013-11-14 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3, 2014
5L3P	Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Arenz, S, Wilson, D.N. 登録日 2016-05-24 公開日 2016-07-20 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis. Nucleic Acids Res., 44, 2016
1QM4	Methionine Adenosyltransferase Complexed with a L-Methionine Analogue 分子名称: L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID, MAGNESIUM ION, METHIONINE ADENOSYLTRANSFERASE, ... 著者 Gonzalez, B, Pajares, M.A, Hermoso, J.A, Sanz-Aparicio, J. 登録日 1999-09-20 公開日 2000-09-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site J.Mol.Biol., 300, 2000
1ULZ	Crystal structure of the biotin carboxylase subunit of pyruvate carboxylase 分子名称: pyruvate carboxylase n-terminal domain 著者 Kondo, S, Nakajima, Y, Sugio, S, Yong-Biao, J, Sueda, S, Kondo, H. 登録日 2003-09-18 公開日 2004-03-09 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution. Acta Crystallogr.,Sect.D, 60, 2004
4NM7	Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADENOSINE-5'-DIPHOSPHATE, Axin-1, ... 著者 Stamos, J.L, Chu, M.L.-H, Enos, M.D, Shah, N, Weis, W.I. 登録日 2013-11-14 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3, 2014
6LTW	Crystal structure of Apo form of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis 分子名称: MAGNESIUM ION, PHOSPHATE ION, S-adenosylmethionine synthase 著者 Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D. 登録日 2020-01-23 公開日 2020-10-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew.Chem.Int.Ed.Engl., 60, 2021
6LTV	Crystal Structure of I122A/I330A variant of S-adenosylmethionine synthetase from Cryptosporidium hominis in complex with ONB-SAM (2-nitro benzyme S-adenosyl-methionine) 分子名称: MAGNESIUM ION, S-adenosylmethionine synthase, TRIPHOSPHATE, ... 著者 Singh, R.K, Michailidou, F, Rentmeister, A, Kuemmel, D. 登録日 2020-01-23 公開日 2020-10-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions. Angew.Chem.Int.Ed.Engl., 60, 2021
6ASV	E. coli PRPP Synthetase 分子名称: CHLORIDE ION, PHOSPHATE ION, Ribose-phosphate pyrophosphokinase 著者 French, J.B, Zhou, W. 登録日 2017-08-25 公開日 2019-01-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal structure of E. coli PRPP synthetase. BMC Struct. Biol., 19, 2019
3HVC	Crystal structure of human p38alpha MAP kinase 分子名称: 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, Mitogen-activated protein kinase 14 著者 Perry, J.J, Tainer, J.A. 登録日 2009-06-15 公開日 2009-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses. J.Mol.Biol., 391, 2009
7KC7	Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to ADP without Magnesium with disordered phosphate tail 分子名称: 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION 著者 Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V. 登録日 2020-10-05 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase. Biochemistry, 60, 2021
7KCT	Crystal Structure of the Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase (OGC) Biotin Carboxylase (BC) Domain Dimer in Complex with Adenosine 5'-Diphosphate Magnesium Salt (MgADP), Adenosine 5'-Diphosphate (ADP, and Bicarbonate Anion (Hydrogen Carbonate/HCO3-) 分子名称: 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ... 著者 Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V. 登録日 2020-10-07 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase. Biochemistry, 60, 2021
7KBL	Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to Bicarbonate 分子名称: 2-oxoglutarate carboxylase small subunit, BICARBONATE ION 著者 Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V. 登録日 2020-10-02 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase. Biochemistry, 60, 2021
4J1R	Crystal Structure of GSK3b in complex with inhibitor 15R 分子名称: (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION, ... 著者 Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-02-01 公開日 2013-03-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
4J71	Crystal Structure of GSK3b in complex with inhibitor 1R 分子名称: (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, CHLORIDE ION, Glycogen synthase kinase-3 beta, ... 著者 Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-02-12 公開日 2013-03-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
4KRD	Crystal Structure of Pho85-Pcl10 Complex 分子名称: Cyclin-dependent protein kinase PHO85, PHO85 cyclin-10 著者 Quiocho, F.A, Zheng, F. 登録日 2013-05-16 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition. J.Biol.Chem., 288, 2013
1KQP	NH3-DEPENDENT NAD+ SYNTHETASE FROM BACILLUS SUBTILIS AT 1 A RESOLUTION 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase, ... 著者 Symersky, J, Devedjiev, Y, Moore, K, Brouillette, C, DeLucas, L. 登録日 2002-01-07 公開日 2002-06-28 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 NH3-dependent NAD+ synthetase from Bacillus subtilis at 1 A resolution. Acta Crystallogr.,Sect.D, 58, 2002
3CQU	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 分子名称: Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, RAC-alpha serine/threonine-protein kinase 著者 Pandit, J. 登録日 2008-04-03 公開日 2008-05-27 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
3CQW	Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor 分子名称: 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ... 著者 Pandit, J. 登録日 2008-04-03 公開日 2008-05-27 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
3C8Z	The 1.6 A Crystal Structure of MshC: The Rate Limiting Enzyme in the Mycothiol Biosynthetic Pathway 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, Cysteinyl-tRNA synthetase, ... 著者 Tremblay, L.W, Fan, F, Vetting, M.W, Blanchard, J.S. 登録日 2008-02-14 公開日 2008-12-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway. Biochemistry, 47, 2008
3G8C	Crystal Structure of Biotin Carboxylase in Complex with Biotin, Bicarbonate, ADP and Mg Ion 分子名称: ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, BIOTIN, ... 著者 Chou, C.Y, Yu, L.P, Tong, L. 登録日 2009-02-12 公開日 2009-03-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. J.Biol.Chem., 284, 2009

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