6K39

Structural analysis of AIMP2-DX2 and HSP70 interaction

Summary for 6K39

Entry DOI	10.2210/pdb6k39/pdb
Descriptor	Heat shock 70 kDa protein 1A,Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (2 entities in total)
Functional Keywords	hsp70, aimp2-dx2, substrate binding domain, chaperone
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	33475.65
Authors	Cho, H.Y.,Son, S.Y.,Jeon, Y.H. (deposition date: 2019-05-16, release date: 2019-10-02, Last modification date: 2023-11-22)
Primary citation	Lim, S.,Cho, H.Y.,Kim, D.G.,Roh, Y.,Son, S.Y.,Mushtaq, A.U.,Kim, M.,Bhattarai, D.,Sivaraman, A.,Lee, Y.,Lee, J.,Yang, W.S.,Kim, H.K.,Kim, M.H.,Lee, K.,Jeon, Y.H.,Kim, S. Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development. Nat.Chem.Biol., 16:31-41, 2020 Cited by PubMed: 31792442 DOI: 10.1038/s41589-019-0415-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3981426881 Å)

Structure validation