PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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6DUR	Citrobacter freundii tyrosine phenol-lyase complexed with L-phenylalanine 分子名称: (2E)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}-3-phenylpropanoic acid, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-phenylalanine, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... 著者 Phillips, R.S. 登録日 2018-06-21 公開日 2018-10-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of Wild-Type and F448A Mutant Citrobacter freundii Tyrosine Phenol-Lyase Complexed with a Substrate and Inhibitors: Implications for the Reaction Mechanism. Biochemistry, 57, 2018
6DDW	Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid 分子名称: Dihydrofolate reductase, GLYCEROL, N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid, ... 著者 Hajian, B, Scocchera, E, Wright, D. 登録日 2018-05-10 公開日 2018-05-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents. Cell Chem Biol, 26, 2019
6DGY	Crystal structure of HIV-1 Protease NL4-3 WT in complex with UMass1 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.954 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6DH7	Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with UMass1 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.997 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6D52	Superoxide dismutase SodCI of Salmonella enterica serovar Typhimurium at 1.6 Angstrom resolution 分子名称: COPPER (II) ION, Superoxide dismutase [Cu-Zn] 1, ZINC ION 著者 Newhouse IX, P.W, Forest, K.T, Satyshur, K.A. 登録日 2018-04-19 公開日 2019-05-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Superoxide dismutase SodCI of Salmonella enterica serovar Typhimurium at 1.6 Angstrom resolution to be published
6D5L	Ras:SOS:Ras in complex with a small molecule activator 分子名称: 6-chloro-1-[(3-chloro-4-fluorophenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazole, FORMIC ACID, GLYCEROL, ... 著者 Phan, J, Hodges, T, Fesik, S.W. 登録日 2018-04-19 公開日 2018-09-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J. Med. Chem., 61, 2018
6D6A	The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 10 分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl benzoate, Transcriptional activator protein LasR 著者 Dong, S.H, Nair, S.K. 登録日 2018-04-20 公開日 2018-08-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
6DIO	Structure of class II HMG-CoA reductase from Delftia acidovorans with NAD bound 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-3-methylglutaryl coenzyme A reductase, CITRIC ACID, ... 著者 Ragwan, E.R, Arai, E, Kung, Y. 登録日 2018-05-23 公開日 2018-09-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 New Crystallographic Snapshots of Large Domain Movements in Bacterial 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase. Biochemistry, 57, 2018
6DJ5	HIV-1 protease with mutation L76V in complex with GRL-0519 (tris-tetrahydrofuran as P2 ligand) 分子名称: (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, GLYCEROL, ... 著者 Wong-Sam, A.E, Wang, Y.F, Weber, I.T. 登録日 2018-05-24 公開日 2018-10-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease. ACS Omega, 3, 2018
6DJB	Structure of human Volume Regulated Anion Channel composed of SWELL1 (LRRC8A) 分子名称: Volume-regulated anion channel subunit LRRC8A 著者 Kefauver, J.M, Saotome, K, Pallesen, J, Cottrell, C.A, Ward, A.B, Patapoutian, A. 登録日 2018-05-24 公開日 2018-08-15 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structure of the human volume regulated anion channel. Elife, 7, 2018
6D83	Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit 分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... 著者 Buffalo, C.Z, Morris, K.L, Hurley, J.H. 登録日 2018-04-25 公開日 2018-08-08 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.27 Å) 主引用文献 HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
6DNB	Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) 分子名称: Aspartate aminotransferase, cytoplasmic, GLYCEROL, ... 著者 Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. 登録日 2018-06-06 公開日 2018-11-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry, 57, 2018
6DO7	NMR solution structure of wild type hFABP1 with GW7647 分子名称: Fatty acid-binding protein, liver 著者 Scanlon, M.J, Mohanty, B, Doak, B.C, Patil, R. 登録日 2018-06-09 公開日 2019-01-02 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor alpha agonists. J. Biol. Chem., 294, 2019
6DQ2	Cronobacter sakazakii (Enterobacter sakazakii) Metallo-beta-lactamse HARLDQ motif mutant S60 分子名称: Beta-lactamase, PHOSPHATE ION 著者 Monteiro Pedroso, M, Waite, D, Natasa, M, McGeary, R, Guddat, L, Hugenholtz, P, Schenk, G. 登録日 2018-06-10 公開日 2019-06-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.158 Å) 主引用文献 Broad spectrum antibiotic-degrading metallo-beta-lactamases are phylogenetically diverse Protein Cell, 2020
6DRQ	The crystal structure of SatS c-terminal domain in complex with bromine 分子名称: BROMIDE ION, Primosomal protein 著者 Hughes, R.C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2018-06-12 公開日 2019-01-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mycobacterium tuberculosisSatS is a chaperone for the SecA2 protein export pathway. Elife, 8, 2019
6DRT	Crystal structure of the processivity clamp GP45 complexed with recognition peptide of ligase from bacteriophage T4 分子名称: 1,2-ETHANEDIOL, DNA polymerase clamp, GP45 recognition loop 著者 Shi, K, Aihara, H. 登録日 2018-06-13 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.117 Å) 主引用文献 T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction. Nucleic Acids Res., 46, 2018
6DED	Crystal structure of the C-terminal ARM domain of Homo sapiens SPIN90 (SH3-protein interacting with Nck), residues 351-722 分子名称: NCK-interacting protein with SH3 domain 著者 Nolen, B.J, Luan, Q. 登録日 2018-05-11 公開日 2018-10-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.204 Å) 主引用文献 Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. EMBO J., 37, 2018
6DRW	JAK2 JH1 in complex with JNJ-7706621 (Crystal Form 2) 分子名称: 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Tyrosine-protein kinase JAK2 著者 Puleo, D.E, Schlessinger, J. 登録日 2018-06-13 公開日 2018-07-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 JAK2 JH2 Binders To Be Published
6DEN	Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl 分子名称: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, CARBON DIOXIDE, ... 著者 Garcia, M.D, Guddat, L.W. 登録日 2018-05-12 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.806 Å) 主引用文献 Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DEV	Human caspase-6 E35K 分子名称: Caspase-6 著者 Tubeleviciute-Aydin, A, Beautrait, A, Lynham, J, Sharma, G, Gorelik, A, Deny, L.J, Soya, N, Lukacs, G.L, Nagar, B, Marinier, A, LeBlanc, A.C. 登録日 2018-05-13 公開日 2019-03-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.348 Å) 主引用文献 Identification of Allosteric Inhibitors against Active Caspase-6. Sci Rep, 9, 2019
6DH2	Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with UMass6 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION 著者 Lockbaum, G.J, Schiffer, C.A. 登録日 2018-05-18 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.978 Å) 主引用文献 Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS Infect Dis, 5, 2019
6DHB	Crystal structure of the human TIM-3 with bound Calcium 分子名称: 1,2-ETHANEDIOL, BENZOIC ACID, CALCIUM ION, ... 著者 Gandhi, A.K, Kim, W.M, Huang, Y.H, Bonsor, D, Sundberg, E, Sun, Z.-Y, Petsko, G.A, Kuchroo, V, Blumberg, R.S. 登録日 2018-05-19 公開日 2018-12-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep, 8, 2018
6DV1	Crystal structure of the alpha-E-catenin actin-binding domain 分子名称: BROMIDE ION, Catenin alpha-1, SULFATE ION 著者 Ishiyama, N, Ikura, M. 登録日 2018-06-22 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Force-dependent allostery of the alpha-catenin actin-binding domain controls adherens junction dynamics and functions. Nat Commun, 9, 2018
6DHK	Bovine glutamate dehydrogenase complexed with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutamate dehydrogenase 1, mitochondrial 著者 Smith, T.J. 登録日 2018-05-20 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation. Biochemistry, 42, 2003
6DVY	Cryo-EM structure of mouse TRPV3 in complex with 2-Aminoethoxydiphenyl borate (2-APB) 分子名称: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3 著者 Singh, A.K, McGoldrick, L.L, Sobolevsky, A.I. 登録日 2018-06-25 公開日 2018-09-05 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure and gating mechanism of the transient receptor potential channel TRPV3. Nat. Struct. Mol. Biol., 25, 2018

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