PDB: 73050 件ウェブページステータス検索Chemie searchBIRD

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3R3L	Structure of NP protein from Lassa AV strain 分子名称: MANGANESE (II) ION, Nucleoprotein, ZINC ION 著者 Perbandt, M, Brunotte, L, Gunther, S, Betzel, C. 登録日 2011-03-16 公開日 2011-09-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.449 Å) 主引用文献 Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J.Biol.Chem., 286, 2011
3Q4T	Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin 分子名称: 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-2A, ... 著者 Chaikuad, A, Alfano, I, Mahajan, P, Cooper, C.D.O, Sanvitale, C, Vollmar, M, Krojer, T, Muniz, J.R.C, Raynor, J, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) 登録日 2010-12-24 公開日 2011-02-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation. J.Biol.Chem., 290, 2015
3PL6	Structure of Autoimmune TCR Hy.1B11 in complex with HLA-DQ1 and MBP 85-99 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MBP peptide / T-cell receptor beta chain chimera, MHC class II HLA-DQ-alpha chain, ... 著者 Sethi, D.K, Wucherpfennig, K.W. 登録日 2010-11-13 公開日 2010-12-22 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J.Exp.Med., 208, 2011
4H1U	Nucleotide-free human dynamin-1-like protein GTPase-GED fusion 分子名称: CITRATE ANION, Dynamin-1-like protein 著者 Wenger, J, Klinglmayr, E, Puehringer, S, Goettig, P. 登録日 2012-09-11 公開日 2013-08-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses. Plos One, 8, 2013
3Q0C	Crystal structure of SUVH5 SRA-fully methylated CG DNA complex in space group P6122 分子名称: DNA (5'-D(*AP*CP*TP*AP*(5CM)P*GP*TP*AP*GP*TP*T)-3'), Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5, ... 著者 Eerappa, R, Simanshu, D.K, Patel, D.J. 登録日 2010-12-15 公開日 2011-02-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6567 Å) 主引用文献 A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev., 25, 2011
4K9A	Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pG(2 ,5 )pA 分子名称: ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ... 著者 Gao, P, Wu, Y, Patel, D.J. 登録日 2013-04-19 公開日 2013-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.264 Å) 主引用文献 Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
4HCV	Crystal structure of ITK in complex with compound 53 分子名称: 3-{4-amino-1-[(3S)-1-propanoylpiperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(propan-2-yl)phenyl]benzamide, Tyrosine-protein kinase ITK/TSK 著者 Han, S, Caspers, N. 登録日 2012-10-01 公開日 2012-11-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay. J.Med.Chem., 55, 2012
4K97	Structure of Ternary Complex of cGAS with dsDNA and Bound ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ... 著者 Gao, P, Wu, Y, Patel, D.J. 登録日 2013-04-19 公開日 2013-05-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
3PNY	Structure of Glutamyl-tRNA synthetase from Mycobacterium tuberculosis in space group P21 分子名称: Glutamyl-tRNA synthetase 著者 Kachalova, G.S, Laurinavichiute, D, Bartunik, H.D. 登録日 2010-11-20 公開日 2011-12-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural analysis of the non-discriminating glutamyl-tRNA synthetase from Mycobacterium tuberculosis suggests minor role of anticodon recognition in tRNA(Gln) discrimination To be Published
4K9H	Bace-1 inhibitor complex 分子名称: 1-cyclopentyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-{[3-(trifluoromethyl)benzyl]amino}butan-2-yl]-6-oxo-5-(2-oxopyrrolidin-1-yl)-1,6-dihydropyridine-3-carboxamide, Beta-secretase 1 著者 Jordan, S.R. 登録日 2013-04-19 公開日 2013-07-10 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity. Bioorg.Med.Chem.Lett., 23, 2013
3TJD	co-crystal structure of Jak2 with thienopyridine 19 分子名称: 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 著者 Huang, X. 登録日 2011-08-24 公開日 2011-11-30 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
4LKF	Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with GalA-WKY at 1.64 A Resolution 分子名称: CALCIUM ION, P-HYDROXYBENZOIC ACID, PA-I galactophilic lectin, ... 著者 Kadam, R.U, Stocker, A, Reymond, J.-L. 登録日 2013-07-07 公開日 2013-12-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. Chemistry, 19, 2013
4EM9	Human PPAR gamma in complex with nonanoic acids 分子名称: 3,3',3''-phosphanetriyltripropanoic acid, GLYCEROL, Peroxisome proliferator-activated receptor gamma, ... 著者 Liberato, M.V, Nascimento, A.S, Polikarpov, I. 登録日 2012-04-11 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) Gamma activators and pan-PPAR partial agonists Plos One, 7, 2012
4LLV	The structure of the unbound form of anti-HIV antibody 4E10 Fv 分子名称: 4E10 Fv heavy chain, 4E10 Fv light chain, GLYCEROL, ... 著者 Finton, K.A.K, Rupert, P.B, Strong, R.K. 登録日 2013-07-09 公開日 2013-10-16 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10. Plos Pathog., 9, 2013
4EO0	crystal structure of the pilus binding domain of the filamentous phage IKe 分子名称: Attachment protein G3P 著者 Jakob, R.P, Geitner, A.J, Weininger, U, Balbach, J, Dobbek, H, Schmid, F.X. 登録日 2012-04-13 公開日 2012-05-30 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structural and energetic basis of infection by the filamentous bacteriophage IKe. Mol.Microbiol., 84, 2012
4LOH	Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(3',5')p] 分子名称: Stimulator of interferon genes protein, cGAMP 著者 Gao, P, Patel, D.J. 登録日 2013-07-12 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.), 154, 2013
4LOJ	Crystal structure of mSting in complex with c[G(2',5')pA(3',5')p] 分子名称: Stimulator of interferon genes protein, cGAMP 著者 Gao, P, Patel, D.J. 登録日 2013-07-12 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.), 154, 2013
3RSX	Structure of Bace-1 (Beta-Secretase) in Complex with 6-(Thiophen-3-yl)quinolin-2-amine 分子名称: 6-(thiophen-3-yl)quinolin-2-amine, Beta-secretase 1, IODIDE ION 著者 Sickmier, E.A. 登録日 2011-05-02 公開日 2011-08-31 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
3U65	The Crystal Structure of Tat-P(T) (Tp0957) 分子名称: 1,2-ETHANEDIOL, THIOCYANATE ION, Tp33 protein 著者 Brautigam, C.A, Tomchick, D.R, Deka, R.K, Norgard, M.V. 登録日 2011-10-12 公開日 2012-02-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter. J.Mol.Biol., 416, 2012
4LXD	Bcl_2-Navitoclax Analog (without Thiophenyl) Complex 分子名称: 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide, Apoptosis regulator Bcl-2 著者 Park, C.H. 登録日 2013-07-29 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19, 2013
4EEH	Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-(4-Hydroxy-phenyl)-1H-indazol-6-ol 分子名称: 3-(4-hydroxyphenyl)-1H-indazol-6-ol, Heat shock protein HSP 90-alpha, SULFATE ION 著者 Musil, D, Lehmann, M, Graedler, U, Buchstaller, H.-P. 登録日 2012-03-28 公開日 2012-06-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 Bioorg.Med.Chem.Lett., 22, 2012
3TL3	Structure of a short-chain type dehydrogenase/reductase from Mycobacterium ulcerans 分子名称: SODIUM ION, Short-chain type dehydrogenase/reductase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-08-29 公開日 2011-09-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3TNY	Structure of YfiY from Bacillus cereus bound to the siderophore iron (III) schizokinen 分子名称: YfiY (ABC transport system substrate-binding protein), [2-(hydroxy-kappaO)-4-[(3-{(hydroxy-kappaO)[1-(hydroxy-kappaO)ethenyl]amino}propyl)amino]-2-{2-[(3-{(hydroxy-kappaO)[1- (hydroxy-kappaO)ethenyl]amino}propyl)amino]-2-oxoethyl}-4-oxobutanoato(6-)-kappaO]iron 著者 Clifton, M.C. 登録日 2011-09-02 公開日 2012-09-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands To be Published
3TO7	Crystal structure of yeast Esa1 HAT domain bound to coenzyme A with active site lysine acetylated 分子名称: CACODYLIC ACID, COENZYME A, GLYCEROL, ... 著者 Yuan, H, Ding, E.C, Marmorstein, R. 登録日 2011-09-04 公開日 2011-11-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J., 31, 2011
4EFT	Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile 分子名称: (2R)-3-cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)propanenitrile, Heat shock protein HSP 90-alpha 著者 Musil, D, Lehmann, M, Graedler, U, Buchstaller, H.-P. 登録日 2012-03-30 公開日 2012-06-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 Bioorg.Med.Chem.Lett., 22, 2012

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