PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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6XJF	X-ray crystal structure of Pyrococcus furiosus general transcription factor TFE-alpha (SeMet labeled protein) 分子名称: Transcription factor E 著者 Murakami, K.S, Jun, S.H. 登録日 2020-06-23 公開日 2020-07-08 最終更新日 2021-01-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase. Nat Commun, 11, 2020
8PBL	E. coli RNA polymerase elongation complex stalled at thymine dimer lesion 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Woodgate, J, Zenkin, N. 登録日 2023-06-09 公開日 2023-10-25 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Translation selectively destroys non-functional transcription complexes. Nature, 626, 2024
4ZRL	Structure of the non canonical Poly(A) polymerase complex GLD-2 - GLD-3 分子名称: CHLORIDE ION, Defective in germ line development protein 3, Poly(A) RNA polymerase gld-2 著者 Nakel, K, Bonneau, F, Eckmann, C.R, Conti, E. 登録日 2015-05-12 公開日 2015-07-08 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc.Natl.Acad.Sci.USA, 112, 2015
6H80	Dengue-RdRp3-inhibitor complex co-crystallisation 分子名称: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2018-07-31 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
6H9R	Dengue-RdRp3-inhibitor complex soaking 分子名称: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2018-08-05 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
6SZU	Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence 分子名称: 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Wandzik, J.M, Kouba, T, Cusack, S. 登録日 2019-10-02 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.41 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A 分子名称: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... 著者 Lilic, M, Darst, S.A, Campbell, E.A. 登録日 2018-05-06 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6TW1	Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence 分子名称: 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Wandzik, J.M, Kouba, T, Cusack, S. 登録日 2020-01-11 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 2020
6NPW	SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide 分子名称: PHOSPHATE ION, Ser2/Ser5 phosphorylated peptide, Ssu72 ortholog, ... 著者 Irani, S, Zhang, Y. 登録日 2019-01-18 公開日 2019-04-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.486 Å) 主引用文献 Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription. J.Biol.Chem., 294, 2019
7QXI	Cryo-EM structure of RNA polymerase-sigma54 holo enzyme with promoter DNA closed complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Ye, F.Z, Zhang, X.D. 登録日 2022-01-26 公開日 2022-11-09 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Mechanisms of DNA opening revealed in AAA+ transcription complex structures. Sci Adv, 8, 2022
6AE4	Crystals structure of Classical swine fever virus NS5B (residues 1-694, Y471A mutant) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6AE6	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A mutant, form 2) 分子名称: ACETATE ION, RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.856 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6AE7	Crystals structure of Classical swine fever virus NS5B (residues 1-672, E472A mutant) 分子名称: ACETATE ION, RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6AE5	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A mutant, form 1) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.754 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6UTY	E. coli sigma-S transcription initiation complex with a mismatching CTP ("Old" crystal soaked with CTP for 30 minutes) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.15 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UTX	E. coli sigma-S transcription initiation complex with an empty bubble ("Old" crystal) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.05 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UUB	E. coli sigma-S transcription initiation complex with a mismatching UTP ("Fresh" crystal soaked with UTP for 2 hours) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.955 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
6UUA	E. coli sigma-S transcription initiation complex with a mismatching CTP ("Fresh" crystal soaked with CTP for 2 hours) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Zuo, Y, De, S, Steitz, T.A. 登録日 2019-10-30 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.002 Å) 主引用文献 Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation. Iscience, 23, 2020
5YF5	Crystals structure of Classical swine fever virus NS5B (residues 1-694) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2017-09-20 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
4UD4	Structural Plasticity of Cid1 Provides a Basis for its RNA Terminal Uridylyl Transferase Activity 分子名称: GLYCEROL, POLY(A) RNA POLYMERASE PROTEIN CID1 著者 Yates, L.A, Durrant, B.P, Fleurdepine, S, Harlos, K, Norbury, C.J, Gilbert, R.J.C. 登録日 2014-12-07 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity. Nucleic Acids Res., 43, 2015
4UD5	Structural Plasticity of Cid1 Provides a Basis for its RNA Terminal Uridylyl Transferase Activity 分子名称: POLY(A) RNA POLYMERASE PROTEIN CID1 著者 Yates, L.A, Durrant, B.P, Fleurdepine, S, Harlos, K, Norbury, C.J, Gilbert, R.J.C. 登録日 2014-12-07 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Structural Plasticity of Cid1 Provides a Basis for its Distributive RNA Terminal Uridylyl Transferase Activity. Nucleic Acids Res., 43, 2015
5FMZ	Crystal structure of Influenza B polymerase with bound 5' vRNA 分子名称: 5'-R(*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP)-3', POLYMERASE ACIDIC PROTEIN, POLYMERASE BASIC PROTEIN 2, ... 著者 Guilligay, D, Cusack, S. 登録日 2015-11-10 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016
5D4E	Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP 分子名称: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
6RFG	Structure of the Vaccinia core protein E11 分子名称: 15 kDa core protein 著者 Grimm, C, Fischer, U. 登録日 2019-04-15 公開日 2019-12-11 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell, 179, 2019
7CTT	Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Peng, Q, Peng, R, Shi, Y. 登録日 2020-08-20 公開日 2020-09-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. Innovation (N Y), 2, 2021

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