9B59
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9IIL
| Structure of the complex of erythrose-4-phosphate dehydrogenase from Acinetobacter baumannii with nicotinamide adenine dinucleotide in the presence of poly(ethylene glycol) at 2.20 A resolution | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | 著者 | Viswanathan, V, Kumari, A, Singh, A, Kumar, A, Sharma, P, Chopra, S, Jeyakanthan, J, Sharma, S, Raje, C.I, Singh, T.P. | 登録日 | 2024-06-20 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the complex of erythrose-4-phosphate dehydrogenase from Acinetobacter baumannii with nicotinamide adenine dinucleotide in the presence of poly(ethylene glycol) at 2.20 A resolution To Be Published
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9BNJ
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8Y95
| Structure of NET-NE in Occluded state | 分子名称: | CHLORIDE ION, Noradrenaline, SODIUM ION, ... | 著者 | Zhang, H, Xu, H.E, Jiang, Y. | 登録日 | 2024-02-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Dimerization and antidepressant recognition at noradrenaline transporter. Nature, 630, 2024
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9B5H
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9IJB
| Crystal structure and function analysis of a highly potential drug target 6-phosphogluconate dehydrogenase in Mycobacterium tuberculosis | 分子名称: | 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating | 著者 | Wang, Y.Z, Ren, X.Q, Li, T, Zhang, R.D. | 登録日 | 2024-06-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.740405 Å) | 主引用文献 | Crystal structure and function analysis of 6-phosphogluconate dehydrogenase in Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun., 731, 2024
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6DCF
| Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A | 分子名称: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | 著者 | Lilic, M, Darst, S.A, Campbell, E.A. | 登録日 | 2018-05-06 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
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9EUE
| The FK1 domain of FKBP51 in complex with SAFit-analog 23a | 分子名称: | (1-methylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Meyners, C, Buffa, V, Hausch, F. | 登録日 | 2024-03-27 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
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9B3R
| The structure of human cardiac F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | 著者 | Doran, M.H, Sousa, D, Rynkiewicz, M.J, Lehman, W, Cammarato, A. | 登録日 | 2024-03-20 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of human cardiac actin To Be Published
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9EOE
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9BKG
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8XH7
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9EU7
| The FK1 domain of FKBP51 in complex with SAFit-analog 15b | 分子名称: | (2-methyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Meyners, C, Buffa, V, Hausch, F. | 登録日 | 2024-03-27 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
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8YF1
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9EOF
| Structure of the human INTS5/8/10/15 subcomplex | 分子名称: | Integrator complex subunit 10, Integrator complex subunit 15, Integrator complex subunit 5, ... | 著者 | Razew, M, Galej, W.P. | 登録日 | 2024-03-14 | 公開日 | 2024-06-12 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | Structural basis of the Integrator complex assembly and association with transcription factors. Mol.Cell, 84, 2024
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9BEZ
| MID domain of human Argo2 bound to RNA | 分子名称: | Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate | 著者 | Harp, J.M, Egli, M. | 登録日 | 2024-04-16 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
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8ZNG
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9BKL
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9BVV
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8Z76
| The structure of thiocyanate dehydrogenase from Pelomicrobium methylotrophicum (pmTcDH), activated by crystals soaking with 1 mM CuCl2 during 6 months | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, SODIUM ION, ... | 著者 | Varfolomeeva, L.A, Solovieva, A.Y, Shipkov, N.S, Dergousova, N.I, Boyko, K.M, Tikhonova, T.V, Popov, V.O. | 登録日 | 2024-04-19 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The structure of thiocyanate dehydrogenase from Pelomicrobium methylotrophicum (pmTcDH), activated by crystals soaking with 1 mM CuCl2 To Be Published
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8ZAV
| alcohol dehydrogenases KpADH mutant - S9Y/F161K | 分子名称: | 1,2-ETHANEDIOL, NAD-dependent epimerase/dehydratase domain-containing protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Zhang, L, Ni, Y, Xu, G.C. | 登録日 | 2024-04-25 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Engineering alcohol dehydrogenases KpADH for enhanced organic-solvent tolerance and its molecular mechanisms To Be Published
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9BF0
| MID domain of human Argo2 bound to UTP | 分子名称: | Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE | 著者 | Harp, J.M, Egli, M. | 登録日 | 2024-04-16 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
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9BF2
| MID domain of Ago2 bound to UMP | 分子名称: | Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE | 著者 | Harp, J.M, Egli, M. | 登録日 | 2024-04-16 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
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9EUA
| The FK1 domain of FKBP51 in complex with SAFit-analog 23d | 分子名称: | (1-propylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Meyners, C, Buffa, V, Hausch, F. | 登録日 | 2024-03-27 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
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9FWG
| LSD1/CoREST bound to bomedemstat | 分子名称: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | 著者 | Speranzini, V, Mattevi, A. | 登録日 | 2024-06-30 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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