8C86
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![BU of 8c86 by Molmil](/molmil-images/mine/8c86) | Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2 | 分子名称: | (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Poonsiri, T, Benini, S, Loconte, V, Cianci, M. | 登録日 | 2023-01-18 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
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8C85
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![BU of 8c85 by Molmil](/molmil-images/mine/8c85) | Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1 | 分子名称: | (3,5-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Poonsiri, T, Benini, S, Loconte, V, Cianci, M. | 登録日 | 2023-01-18 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
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7DDI
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![BU of 7ddi by Molmil](/molmil-images/mine/7ddi) | Crystal structures of Na+,K+-ATPase in complex with digitoxin | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | 登録日 | 2020-10-29 | 公開日 | 2021-01-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.72 Å) | 主引用文献 | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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6UG1
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1NDD
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![BU of 1ndd by Molmil](/molmil-images/mine/1ndd) | STRUCTURE OF NEDD8 | 分子名称: | CHLORIDE ION, PROTEIN (UBIQUITIN-LIKE PROTEIN NEDD8), SULFATE ION | 著者 | Whitby, F.G, Xia, G, Pickart, C.M, Hill, C.P. | 登録日 | 1998-08-21 | 公開日 | 1999-02-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. J.Biol.Chem., 273, 1998
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3VRT
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![BU of 3vrt by Molmil](/molmil-images/mine/3vrt) | VDR ligand binding domain in complex with 2-Mehylidene-19,25,26,27-tetranor-1alpha,24-dihydroxyvitaminD3 | 分子名称: | (1R,3R,7E,17beta)-17-[(2R)-5-hydroxypentan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | 著者 | Nakabayashi, M, Yoshimoto, N, Inaba, Y, Itoh, T, Ito, N, Yamamoto, K. | 登録日 | 2012-04-14 | 公開日 | 2012-05-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands J.Med.Chem., 55, 2012
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6UOG
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8FXF
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![BU of 8fxf by Molmil](/molmil-images/mine/8fxf) | Crystal structure of the coiled-coil domain of TRIM56 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase TRIM56 | 著者 | Lou, X.H, Ma, B.B, Zhuang, Y, Li, X.C. | 登録日 | 2023-01-24 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions. Comput Struct Biotechnol J, 21, 2023
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3IJP
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5IFG
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![BU of 5ifg by Molmil](/molmil-images/mine/5ifg) | Crystal structure of HigA-HigB complex from E. Coli | 分子名称: | Antitoxin HigA, mRNA interferase HigB | 著者 | Yang, J.S, Zhou, K, Gao, z.Q, Liu, Q.S, Dong, Y.H. | 登録日 | 2016-02-26 | 公開日 | 2017-03-01 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Structural insight into the E. coli HigBA complex Biochem. Biophys. Res. Commun., 478, 2016
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4PTZ
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![BU of 4ptz by Molmil](/molmil-images/mine/4ptz) | Crystal structure of the Escherichia coli alkanesulfonate FMN reductase SsuE in FMN-bound form | 分子名称: | FLAVIN MONONUCLEOTIDE, FMN reductase SsuE, GLYCEROL, ... | 著者 | Driggers, C.M, Ellis, H.R, Karplus, P.A. | 登録日 | 2014-03-11 | 公開日 | 2014-06-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9007 Å) | 主引用文献 | Crystal Structure of Escherichia coli SsuE: Defining a General Catalytic Cycle for FMN Reductases of the Flavodoxin-like Superfamily. Biochemistry, 53, 2014
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6UOD
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3VIF
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![BU of 3vif by Molmil](/molmil-images/mine/3vif) | Crystal structure of beta-glucosidase from termite Neotermes koshunensis in complex with gluconolactone | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-glucosidase, CHLORIDE ION, ... | 著者 | Jeng, W.Y, Liu, C.I, Wang, A.H.J. | 登録日 | 2011-10-03 | 公開日 | 2012-07-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | High-resolution structures of Neotermes koshunensis beta-glucosidase mutants provide insights into the catalytic mechanism and the synthesis of glucoconjugates Acta Crystallogr.,Sect.D, 68, 2012
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8BZD
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![BU of 8bzd by Molmil](/molmil-images/mine/8bzd) | deAc-FC stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, De-acetylated Fusicoccin, ERalpha peptide, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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8BZG
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![BU of 8bzg by Molmil](/molmil-images/mine/8bzg) | FC-31 stabilizer of 14-3-3 and ERalpha | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, Fusicoccin 31, ... | 著者 | Visser, E.J, Ottmann, C. | 登録日 | 2022-12-14 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
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3VOV
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![BU of 3vov by Molmil](/molmil-images/mine/3vov) | Crystal Structure of ROK Hexokinase from Thermus thermophilus | 分子名称: | GLYCEROL, Glucokinase, ZINC ION | 著者 | Nakamura, T, Kashima, Y, Mine, S, Oku, T, Uegaki, K. | 登録日 | 2012-02-21 | 公開日 | 2012-06-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Characterization and crystal structure of the thermophilic ROK hexokinase from Thermus thermophilus J.Biosci.Bioeng., 2012
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4UCG
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![BU of 4ucg by Molmil](/molmil-images/mine/4ucg) | NmeDAH7PS R126S variant | 分子名称: | DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, ... | 著者 | Cross, P.J, Heyes, L.C, Zhang, S, Nazmi, A.R, Parker, E.J. | 登録日 | 2014-12-03 | 公開日 | 2016-01-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Functional Unit of Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase is Dimeric. Plos One, 11, 2016
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4PM1
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![BU of 4pm1 by Molmil](/molmil-images/mine/4pm1) | Human transthyretin (TTR) complexed with 16-alpha-bromo-estradiol | 分子名称: | (14beta,16alpha,17alpha)-16-bromoestra-1,3,5(10)-triene-3,17-diol, 1,2-ETHANEDIOL, Transthyretin | 著者 | Stura, E.A, Ciccone, L. | 登録日 | 2014-05-20 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | 主引用文献 | Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
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4PMF
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![BU of 4pmf by Molmil](/molmil-images/mine/4pmf) | Human transthyretin (TTR) complexed with curcumin | 分子名称: | (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, SODIUM ION, ... | 著者 | Stura, E.A, Ciccone, L. | 登録日 | 2014-05-21 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
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6XYD
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![BU of 6xyd by Molmil](/molmil-images/mine/6xyd) | Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi | 分子名称: | CHLORIDE ION, MAGNESIUM ION, SODIUM ION, ... | 著者 | Roske, Y, Heinemann, U, Andrea, E.D. | 登録日 | 2020-01-30 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi. J.Struct.Biol., 211, 2020
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6XXI
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![BU of 6xxi by Molmil](/molmil-images/mine/6xxi) | Crystal Structure of Human Deoxyhypusine Synthase in complex with NAD | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Wator, E, Wilk, P, Grudnik, P. | 登録日 | 2020-01-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | 主引用文献 | Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase. Biomolecules, 10, 2020
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7NLV
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![BU of 7nlv by Molmil](/molmil-images/mine/7nlv) | WILDTYPE CORE-STREPTAVIDIN WITH a conjugated BIOTINYLATED PYRROLIDINE II | 分子名称: | 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-((S)-pyrrolidin-3-yl)pentanamide, Streptavidin | 著者 | Nodling, A.R, Santi, N, Tsai, Y.H, Rizkallah, P, Luk, L.Y.P, Jin, Y. | 登録日 | 2021-02-22 | 公開日 | 2022-03-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | The role of streptavidin and its variants in catalysis by biotinylated secondary amines. Org.Biomol.Chem., 19, 2021
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8A62
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![BU of 8a62 by Molmil](/molmil-images/mine/8a62) | Small molecule stabilizer (compound 2) for FOXO1 and 14-3-3 | 分子名称: | (3~{S})-1-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]carbonyl-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-3-carboxamide, 14-3-3 protein sigma, Forkhead box protein O1, ... | 著者 | Kenanova, D.N, Visser, E.J, Virta, J, Sijbesma, E, Centorrino, F, Zhong, M, Vickery, H, Neitz, J, Brunsveld, L, Ottmann, C, Arkin, M.R. | 登録日 | 2022-06-16 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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8A6H
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![BU of 8a6h by Molmil](/molmil-images/mine/8a6h) | Small molecule stabilizer (compound 7) for C-RAF and 14-3-3 | 分子名称: | 14-3-3 protein sigma, 3-[2-(dimethylamino)ethyldisulfanyl]-1-[4-oxidanyl-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]propan-1-one, CHLORIDE ION, ... | 著者 | Kenanova, D.N, Visser, E.J, Virta, J, Sijbesma, E, Centorrino, F, Zhong, M, Vickery, H, Neitz, J, Brunsveld, L, Ottmann, C, Arkin, M.R. | 登録日 | 2022-06-17 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9, 2023
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2DFV
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![BU of 2dfv by Molmil](/molmil-images/mine/2dfv) | Hyperthermophilic threonine dehydrogenase from Pyrococcus horikoshii | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Probable L-threonine 3-dehydrogenase, SULFATE ION, ... | 著者 | Ishikawa, K, Higashi, N, Nakamura, T, Matsuura, T, Nakagawa, A. | 登録日 | 2006-03-03 | 公開日 | 2007-01-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The first crystal structure of L-threonine dehydrogenase. J.Mol.Biol., 366, 2007
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