PDB: 97310 件ウェブページステータス検索Chemie searchBIRD

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5U0D	Identification of a New Zinc Binding Chemotype by Fragment Screening 分子名称: (5R)-5-(2,4-dimethoxyphenyl)-2-sulfanylidene-1,3-oxazolidin-4-one, Carbonic anhydrase 2, GLYCEROL, ... 著者 Peat, T.S, Poulsen, S.A, Ren, B, Dolezal, O, Woods, L.A, Mujumdar, P, Chrysanthopoulos, P.K. 登録日 2016-11-23 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60, 2017
8IPC	The recombinant NZ-1 Fab complexed with the PDZ tandem fragment of A. aeolicus S2P homolog with the PA14 tag inserted between the residues 181 and 184 分子名称: Putative zinc metalloprotease aq_1964, The recombinantly-expressed heavy chain of the monoclonal antibody NZ-1, The recombinantly-expressed light chain of the monoclonal antibody NZ-1 著者 Adachi, Y, Nogi, T. 登録日 2023-03-14 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Recombinant production of antibody antigen-binding fragments with an N-terminal human growth hormone tag in mammalian cells. Protein Expr.Purif., 208-209, 2023
7AXC	Crystal structure of the hPXR-LBD in complex with ferutinine 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Granell, M, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXJ	Crystal structure of the hPXR-LBD in complex with estradiol and clotrimazole 分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ESTRADIOL, Nuclear receptor subfamily 1 group I member 2 著者 Delfosse, V, Granell, M, Blanc, P, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
8F6V	Crystal Structure of Nanobody VHH108 Bound to Its Antigen PA14 Cif 分子名称: CFTR inhibitory factor, Nanobody VHH108 著者 Simard, A.R, Madden, D.R. 登録日 2022-11-17 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif To Be Published
8F6U	Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif 分子名称: CFTR inhibitory factor, Nanobody VHH113 著者 Simard, A.R, Taher, N.M, Mishra, A.K, Madden, D.R. 登録日 2022-11-17 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif To Be Published
7SJU	Myocilin OLF mutant T293K 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-19 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.391 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SIJ	Myocilin OLF mutant E352K 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-14 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SJV	Myocilin OLF mutant T353I 分子名称: CALCIUM ION, Myocilin, C-terminal fragment, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-19 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SKF	Myocilin OLF mutant A445V 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-20 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.282 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SKE	Myocilin OLF mutant R296H 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-20 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SJT	Myocilin OLF mutant K398R 分子名称: CALCIUM ION, Myocilin, C-terminal fragment, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-19 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SJW	Myocilin OLF mutant L303I 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-19 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SKG	Myocilin OLF mutant V329M 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-20 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SIB	Myocilin OLF mutant K500R 分子名称: CALCIUM ION, GLYCEROL, Myocilin, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-13 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7SKD	Myocilin OLF mutant S331L 分子名称: CALCIUM ION, Myocilin, C-terminal fragment, ... 著者 Scelsi, H.S, Barlow, B.M, Lieberman, R.L. 登録日 2021-10-20 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.712 Å) 主引用文献 Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
7AXE	Crystal structure of the hPXR-LBD in complex with oxadiazon 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Harrus, D, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXD	Crystal structure of the hPXR-LBD in complex with fipronil 分子名称: ISOPROPYL ALCOHOL, Nuclear receptor subfamily 1 group I member 2, fipronil 著者 Granell, M, Delfosse, V, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7AXL	Crystal structure of the hPXR-LBD in complex with estradiol and heptachlor endo-epoxide 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ESTRADIOL, Nuclear receptor subfamily 1 group I member 2, ... 著者 Delfosse, V, Granell, M, Blanc, P, Bourguet, W. 登録日 2020-11-09 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Proc.Natl.Acad.Sci.USA, 118, 2021
7S2I	Crystal structure of sulfonamide resistance enzyme Sul1 in complex with 6-hydroxymethylpterin 分子名称: 6-HYDROXYMETHYLPTERIN, CHLORIDE ION, GLYCEROL, ... 著者 Stogios, P.J, Skarina, T, Kim, Y, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-09-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2M	Crystal structure of sulfonamide resistance enzyme Sul3 in complex with 6-hydroxymethylpterin 分子名称: 6-HYDROXYMETHYLPTERIN, Sul3 著者 Stogios, P.J, Skarina, T, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-09-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2J	Crystal structure of sulfonamide resistance enzyme Sul2 apoenzyme 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Stogios, P.J, Skarina, T, Michalska, K, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-09-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2K	Crystal structure of sulfonamide resistance enzyme Sul2 in complex with 7,8-dihydropteroate, magnesium, and pyrophosphate 分子名称: 4-AMINOBENZOIC ACID, 7,8-DIHYDROPTEROATE, CHLORIDE ION, ... 著者 Stogios, P.J, Skarina, T, Michalska, K, Venkatesan, M, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-09-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
7S2L	Crystal structure of sulfonamide resistance enzyme Sul3 apoenzyme 分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ... 著者 Stogios, P.J, Venkatesan, M, Michalska, K, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-09-03 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics. Nat Commun, 14, 2023
2TGP	THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS 分子名称: CALCIUM ION, SULFATE ION, TRYPSIN INHIBITOR, ... 著者 Huber, R, Bode, W, Deisenhofer, J, Schwager, P. 登録日 1982-09-27 公開日 1983-01-18 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Acta Crystallogr.,Sect.B, 39, 1983

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