5U0D

Identification of a New Zinc Binding Chemotype by Fragment Screening

Summary for 5U0D

Entry DOI	10.2210/pdb5u0d/pdb
Related	5TY1 5TY8 5TY9 5TYA 5U0E 5U0F 5U0G
Descriptor	Carbonic anhydrase 2, ZINC ION, (5R)-5-(2,4-dimethoxyphenyl)-2-sulfanylidene-1,3-oxazolidin-4-one, ... (5 entities in total)
Functional Keywords	fragment screening, carbonic anhydrase, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29699.84
Authors	Peat, T.S.,Poulsen, S.A.,Ren, B.,Dolezal, O.,Woods, L.A.,Mujumdar, P.,Chrysanthopoulos, P.K. (deposition date: 2016-11-23, release date: 2017-08-30, Last modification date: 2023-10-04)
Primary citation	Chrysanthopoulos, P.K.,Mujumdar, P.,Woods, L.A.,Dolezal, O.,Ren, B.,Peat, T.S.,Poulsen, S.A. Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60:7333-7349, 2017 Cited by PubMed: 28817930 DOI: 10.1021/acs.jmedchem.7b00606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation