PDB: 1556 件ウェブページステータス検索Chemie searchBIRD

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1I91	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE 分子名称: 6-[N-(3-HYDROXY-PHENYL)-3-(MORPHOLIN-4-YLMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-1,1,-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W. 登録日 2001-03-16 公開日 2001-03-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J.Med.Chem., 45, 2002
5DSL	Structure of CO2 released holo-form of human carbonic anhydrase II with 10 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5DSK	Structure of CO2 released holo-form of human carbonic anhydrase II with 3 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5DSQ	Structure of CO2 released apo-form of human carbonic anhydrase II with 3 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5DSM	Structure of CO2 released holo-form of human carbonic anhydrase II with 25 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5DSR	Structure of CO2 released apo-form of human carbonic anhydrase II with 10 min warming 分子名称: Carbonic anhydrase 2, GLYCEROL 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5DSP	Structure of CO2 released apo-form of human carbonic anhydrase II with 40 sec warming 分子名称: Carbonic anhydrase 2, GLYCEROL 著者 Kim, C.U, Park, S.Y, McKenna, R. 登録日 2015-09-17 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5C8I	Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide 分子名称: Carbonic anhydrase 2, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION 著者 Aggarwal, M, Kovalevsky, A.Y, Fisher, S.Z, McKenna, R. 登録日 2015-06-25 公開日 2016-07-20 最終更新日 2024-03-06 実験手法 NEUTRON DIFFRACTION (1.56 Å), X-RAY DIFFRACTION 主引用文献 Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug. IUCrJ, 3, 2016
3KWA	Polyamines inhibit carbonic anhydrases 分子名称: Carbonic anhydrase 2, MERCURY (II) ION, SPERMINE, ... 著者 Temperini, C. 登録日 2009-12-01 公開日 2010-07-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule J.Med.Chem., 53, 2010
1HEA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1992-07-16 公開日 1992-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1BNW	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, N-(2-THIENYLMETHYL)-2,5-THIOPHENEDISULFONAMIDE, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN4	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN1	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
3BOB	Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2 分子名称: CADMIUM ION, Cadmium-specific carbonic anhydrase 著者 Xu, Y, Feng, L, Jeffrey, P.D, Shi, Y, Morel, F.M.M. 登録日 2007-12-17 公開日 2008-01-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature, 452, 2008
3BOJ	Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 1 without bound metal (CDCA1-R1) 分子名称: ACETATE ION, Cadmium-specific carbonic anhydrase 著者 Xu, Y, Feng, L, Jeffrey, P.D, Shi, Y, Morel, F.M.M. 登録日 2007-12-17 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature, 452, 2008
3BOH	Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 1 with acetate (CDCA1-R1) 分子名称: ACETATE ION, CADMIUM ION, Cadmium-specific carbonic anhydrase 著者 Xu, Y, Feng, L, Jeffrey, P.D, Shi, Y, Morel, F.M.M. 登録日 2007-12-17 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature, 452, 2008
3BOE	Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 2 with acetate (CDCA1-R2) 分子名称: ACETATE ION, CADMIUM ION, Cadmium-specific carbonic anhydrase 著者 Xu, Y, Feng, L, Jeffrey, P.D, Shi, Y, Morel, F.M.M. 登録日 2007-12-17 公開日 2008-01-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature, 452, 2008
3BOC	Carbonic anhydrase from marine diatom Thalassiosira weissflogii- zinc bound domain 2 (CDCA1-R2) 分子名称: Cadmium-specific carbonic anhydrase, ZINC ION 著者 Xu, Y, Feng, L, Jeffrey, P.D, Shi, Y, Morel, F.M.M. 登録日 2007-12-17 公開日 2008-01-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature, 452, 2008
1ZSC	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
1BV3	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, PROTEIN (CARBONIC ANHYDRASE II), UREA, ... 著者 Briganti, F, Mangani, S, Scozzafava, A, Vernaglione, G, Supuran, C.T. 登録日 1998-09-22 公開日 1999-09-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? J.Biol.Inorg.Chem., 4, 1999
1AVN	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR 分子名称: AZIDE ION, CARBONIC ANHYDRASE II, HISTAMINE, ... 著者 Briganti, F, Mangani, S, Orioli, P, Scozzafava, A, Vernaglione, G, Supuran, C.T. 登録日 1997-09-17 公開日 1997-12-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry, 36, 1997
1ZSA	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM 分子名称: CARBONIC ANHYDRASE II 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
3ZNC	MURINE CARBONIC ANHYDRASE IV COMPLEXED WITH BRINZOLAMIDE 分子名称: (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, CARBONIC ANHYDRASE IV, ZINC ION 著者 Stams, T, Chen, Y, Christianson, D.W. 登録日 1998-02-10 公開日 1999-03-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7, 1998
5CXK	Crystal structure of beta carbonic anhydrase from Vibrio cholerae 分子名称: BICARBONATE ION, Carbonic anhydrase, ZINC ION 著者 Ferraroni, M, Supuran, C. 登録日 2015-07-29 公開日 2015-12-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure and kinetic studies of a tetrameric type II beta-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Acta Crystallogr.,Sect.D, 71, 2015
12CA	ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1991-10-01 公開日 1992-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121. J.Biol.Chem., 266, 1991

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