PDB: 1553 件ウェブページステータス検索Chemie searchBIRD

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1I91	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE 分子名称: 6-[N-(3-HYDROXY-PHENYL)-3-(MORPHOLIN-4-YLMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-1,1,-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W. 登録日 2001-03-16 公開日 2001-03-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. J.Med.Chem., 45, 2002
1HEA	CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1992-07-16 公開日 1992-10-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1URT	MURINE CARBONIC ANHYDRASE V 分子名称: CARBONIC ANHYDRASE V, ZINC ION 著者 Boriack-Sjodin, P.A, Christianson, D.W. 登録日 1996-07-03 公開日 1997-01-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-based design of an intramolecular proton transfer site in murine carbonic anhydrase V. Biochemistry, 35, 1996
1THJ	CARBONIC ANHYDRASE FROM METHANOSARCINA 分子名称: CARBONIC ANHYDRASE, ZINC ION 著者 Kisker, C, Schindelin, H, Rees, D.C. 登録日 1996-04-02 公開日 1996-10-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. EMBO J., 15, 1996
4RN4	Human Carbonic anhydrases II in complex with a acetazolamide derivative comprising one hydrophobic and one hydrophilic tail moiety 分子名称: 2-({[1-(beta-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl]methyl}[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]amino)-5-sulfamoyl-1,3,4-thiadiazole, Carbonic anhydrase 2, FORMIC ACID, ... 著者 Ren, B, Tanpure, R, Peat, T.S, Bornaghi, L.F, Vullo, D, Supuran, C.T, Poulsen, S. 登録日 2014-10-22 公開日 2015-01-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site. J.Med.Chem., 58, 2015
4M2U	Carbonic Anhydrase II in complex with Dorzolamide 分子名称: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, ZINC ION 著者 Pinard, M.P, Boone, C.D, Rife, B.D, Supuran, C.T, Mckenna, R. 登録日 2013-08-05 公開日 2013-11-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21, 2013
6T7U	Carborane inhibitor of Carbonic Anhydrase IX 分子名称: Carbonic anhydrase 2, Carborane inhibitor, ZINC ION 著者 Brynda, J, Rezacova, P, Kugler, M, Gruner, B. 登録日 2019-10-23 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. Eur.J.Med.Chem., 200, 2020
6T9Z	Nidocarborane inhibitor of Carbonic Anhydrase IX 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, Nidocarborane, ... 著者 Brynda, J, Rezacova, P, Kugler, M, Gruner, B. 登録日 2019-10-29 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX. Eur.J.Med.Chem., 200, 2020
1V9E	Crystal Structure Analysis of Bovine Carbonic Anhydrase II 分子名称: Carbonic anhydrase II, ZINC ION 著者 Saito, R, Sato, T, Ikai, A, Tanaka, N. 登録日 2004-01-26 公開日 2004-02-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of bovine carbonic anhydrase II at 1.95 A resolution. Acta Crystallogr.,Sect.D, 60, 2004
1ZSC	CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
4RIU	A Carbonic Anhydrase IX Mimic in Complex with a Saccharin-Based Inhibitor 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 Mahon, B.P, McKenna, R. 登録日 2014-10-07 公開日 2015-02-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.651 Å) 主引用文献 Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors. Bioorg.Med.Chem., 23, 2015
3RYV	Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide 分子名称: Carbonic anhydrase 2, N-ethyl-4-sulfamoylbenzamide, ZINC ION 著者 Snyder, P.W, Bai, S, Heroux, A, Whitesides, G.W. 登録日 2011-05-11 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase. J.Am.Chem.Soc., 133, 2011
5C8I	Joint X-ray/neutron structure of Human Carbonic Anhydrase II in complex with Methazolamide 分子名称: Carbonic anhydrase 2, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION 著者 Aggarwal, M, Kovalevsky, A.Y, Fisher, S.Z, McKenna, R. 登録日 2015-06-25 公開日 2016-07-20 最終更新日 2024-03-06 実験手法 NEUTRON DIFFRACTION (1.56 Å), X-RAY DIFFRACTION 主引用文献 Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug. IUCrJ, 3, 2016
1ZSA	CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM 分子名称: CARBONIC ANHYDRASE II 著者 Lesburg, C.A, Christianson, D.W. 登録日 1996-01-09 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35, 1996
4O1K	Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora. 分子名称: Carbonic anhydrase, ZINC ION 著者 Lehneck, R, Neumann, P, Vullo, D, Elleuche, S, Supuran, C.T, Ficner, R, Poggeler, S. 登録日 2013-12-16 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora. Febs J., 281, 2014
1BN4	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, N-[(4-METHOXYPHENYL)METHYL]2,5-THIOPHENEDESULFONAMIDE, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BNW	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, N-(2-THIENYLMETHYL)-2,5-THIOPHENEDISULFONAMIDE, ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-30 公開日 1999-06-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BN1	CARBONIC ANHYDRASE II INHIBITOR 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE), ... 著者 Boriack-Sjodin, P.A, Zeitlin, S, Christianson, D.W. 登録日 1998-07-31 公開日 1999-05-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci., 7, 1998
1BV3	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA 分子名称: 4-(HYDROXYMERCURY)BENZOIC ACID, PROTEIN (CARBONIC ANHYDRASE II), UREA, ... 著者 Briganti, F, Mangani, S, Scozzafava, A, Vernaglione, G, Supuran, C.T. 登録日 1998-09-22 公開日 1999-09-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? J.Biol.Inorg.Chem., 4, 1999
1AVN	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR 分子名称: AZIDE ION, CARBONIC ANHYDRASE II, HISTAMINE, ... 著者 Briganti, F, Mangani, S, Orioli, P, Scozzafava, A, Vernaglione, G, Supuran, C.T. 登録日 1997-09-17 公開日 1997-12-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry, 36, 1997
1FSQ	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE II, COBALT (II) ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-11 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FQN	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-06 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FQM	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE, MERCURY (II) ION, ZINC ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-06 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
9CA2	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Alexander, R.S, Christianson, D.W. 登録日 1991-07-09 公開日 1992-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Engineering the hydrophobic pocket of carbonic anhydrase II. Biochemistry, 30, 1991
4XIW	Carbonic anhydrase Cah3 from Chlamydomonas reinhardtii in complex with acetazolamide 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase, alpha type, ... 著者 Hainzl, T, Grundstrom, C, Benlloch, R, Shevela, D, Shutova, T, Messinger, J, Samuelsson, G, Sauer-Eriksson, A.E. 登録日 2015-01-07 公開日 2015-02-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure and Functional Characterization of Photosystem II-Associated Carbonic Anhydrase CAH3 in Chlamydomonas reinhardtii. Plant Physiol., 167, 2015

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