PDB: 289 件ウェブページステータス検索Chemie searchBIRD

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8UJV	Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide opposite urea lesion 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Tomar, R, Egli, M, Stone, M.P. 登録日 2023-10-11 公開日 2024-03-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024
8UJX	Crystal structure of human polymerase eta with incoming dGMPnPP nucleotide opposite urea lesion 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Tomar, R, Egli, M, Stone, M.P. 登録日 2023-10-11 公開日 2024-03-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta. Biochemistry, 63, 2024
8V7I	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 1 mM Mg2+ for 1800s To Be Published
8V7C	Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Human DNA polymerase eta-DNA-dT primer gemCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7K	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 10 mM Mn2+ for 1800s To Be Published
8V7A	Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Human DNA polymerase eta-DNA-dT primer dCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7J	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:reaction with 20 mM Mg2+ for 600s To Be Published
8V7F	Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ To Be Published
8V7H	Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*A)-R(P*(CAR))-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer ternary complex:ground state at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7B	Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 4-amino-1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Human DNA polymerase eta-DNA-dT primer araCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7E	Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+ To Be Published
8V7D	Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T*())-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Human DNA polymerase eta-DNA-dT primer rCTP insertion ternary complex at pH7.0 (K+ MES) with 1 Ca2+ ion To Be Published
8V7G	Human DNA polymerase eta-DNA-gemC-ended primer-dAMPNPP ternary complex with Mg2+ 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*(U7B))-3'), DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3'), ... 著者 Chang, C, Gao, Y. 登録日 2023-12-04 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mn2+ To Be Published
3OHB	Yeast DNA polymerase eta extending from an 8-oxoG lesion 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*GP*(8OG)P*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... 著者 Silverstein, T.D, Jain, R, Aggarwal, A.K. 登録日 2010-08-17 公開日 2010-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure, 18, 2010
4DL6	Human DNA polymerase eta extending primer immediately after cisplatin crosslink (Pt-GG3). 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Cisplatin, DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*CP*C)-3'), ... 著者 Zhao, Y, Biertumpfel, C, Gregory, M, Hua, Y, Hanaoka, F, Yang, W. 登録日 2012-02-05 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta Proc.Natl.Acad.Sci.USA, 109, 2012
3OHA	Yeast DNA polymerase eta inserting dCTP opposite an 8oxoG lesion 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(P*TP*(8OG)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ... 著者 Silverstein, T.D, Jain, R, Aggarwal, A.K. 登録日 2010-08-17 公開日 2010-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure, 18, 2010
5KFK	Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 300s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFU	Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 80s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFA	Human DNA polymerase eta-DNA ternary complex: ground state at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFJ	Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 180s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFV	Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 140s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KG7	Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 10 mM Zn2+ for 60s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*A)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFD	Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 300s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFN	Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: reaction with 1 mM Mg2+ for 1800s 分子名称: 2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFZ	Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 5 mM Mn2+ for 60s at 14 degree 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

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