3IJ0
| Crystal structure of Eed in complex with a trimethylated histone H3K9 peptide | 分子名称: | Histone H3K9 peptide, Polycomb protein EED | 著者 | Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. | 登録日 | 2009-08-03 | 公開日 | 2009-09-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
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3IJC
| Crystal structure of Eed in complex with NDSB-195 | 分子名称: | ETHYL DIMETHYL AMMONIO PROPANE SULFONATE, Polycomb protein EED | 著者 | Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. | 登録日 | 2009-08-04 | 公開日 | 2009-09-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
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3IJ1
| Crystal structure of Eed in complex with a trimethylated histone H4K20 peptide | 分子名称: | Histone H4K20 peptide, Polycomb protein EED | 著者 | Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. | 登録日 | 2009-08-03 | 公開日 | 2009-09-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
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3JZN
| Structure of EED in apo form | 分子名称: | Polycomb protein EED | 著者 | Xu, C, Bian, C.B, Ouyang, H, Qiu, W, MacKenzie, F, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-23 | 公開日 | 2009-12-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JPX
| EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex | 分子名称: | HISTONE PEPTIDE, Polycomb protein EED | 著者 | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-04 | 公開日 | 2009-10-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JZH
| EED-H3K79me3 | 分子名称: | HISTONE PEPTIDE, Polycomb protein EED | 著者 | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-23 | 公開日 | 2009-12-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3K27
| Complex structure of EED and trimethylated H3K9 | 分子名称: | HISTONE PEPTIDE, Polycomb protein EED | 著者 | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-29 | 公開日 | 2009-12-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JZG
| Structure of EED in complex with H3K27me3 | 分子名称: | HISTONE PEPTIDE, Polycomb protein EED | 著者 | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-23 | 公開日 | 2009-12-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3K26
| Complex structure of EED and trimethylated H3K4 | 分子名称: | HISTONE PEPTIDE, Polycomb protein EED | 著者 | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-29 | 公開日 | 2009-12-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JRP
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4GM8
| Crystal structure of human WD repeat domain 5 with compound MM-102 | 分子名称: | MM-102, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2013-07-31 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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4GM9
| Crystal structure of human WD repeat domain 5 with compound MM-401 | 分子名称: | MM-401, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2014-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of human WD repeat domain 5 with compound MM-401 To be Published
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5KWN
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5M23
| Modulation of MLL1 Methyltransferase Activity | 分子名称: | 4-[(~{E})-[4-[[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-pentanoyl]amino]propanoyl]amino]methyl]phenyl]diazenyl]-~{N}-[(2~{S})-3-methyl-1-oxidanylidene-butan-2-yl]benzamide, WD repeat-containing protein 5 | 著者 | Srinivasan, V. | 登録日 | 2016-10-11 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
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4I79
| Crystal structure of human NUP43 | 分子名称: | Nucleoporin Nup43, UNKNOWN ATOM OR ION, floating chain, ... | 著者 | Xu, C, Tempel, W, Li, Z, He, H, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2012-11-30 | 公開日 | 2013-02-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of human nuclear pore complex component NUP43. Febs Lett., 589, 2015
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5WP3
| Crystal Structure of EED in complex with EB22 | 分子名称: | EB22, Polycomb protein EED, UNKNOWN ATOM OR ION | 著者 | Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2017-08-03 | 公開日 | 2017-09-13 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4GQ1
| Nup37 of S. pombe | 分子名称: | Nup37, SULFATE ION | 著者 | Liu, X, Mitchell, J, Wozniak, R, Blobel, G, Fan, J. | 登録日 | 2012-08-22 | 公開日 | 2012-10-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural evolution of the membrane-coating module of the nuclear pore complex. Proc.Natl.Acad.Sci.USA, 109, 2012
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4H5J
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5MWJ
| Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1 | 分子名称: | DIMETHYL SULFOXIDE, Transducin-like enhancer protein 1, pepide inhibtor | 著者 | McGrath, S, Tortorici, M, Vidler, L, Drouin, L, Westwood, I, Gimeson, P, Van Montfort, R, Hoelder, S. | 登録日 | 2017-01-18 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1. Chemistry, 23, 2017
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4H5I
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5N4A
| Crystal structure of Chlamydomonas IFT80 | 分子名称: | GLYCEROL, Intraflagellar transport protein 80, OXALATE ION | 著者 | Taschner, M, Mourao, A. | 登録日 | 2017-02-10 | 公開日 | 2018-02-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis. Elife, 7, 2018
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4GM3
| Crystal structure of human WD repeat domain 5 with compound MM-101 | 分子名称: | MM-101, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.393 Å) | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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4GMB
| Crystal structure of human WD repeat domain 5 with compound MM-402 | 分子名称: | MM-402, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2014-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.781 Å) | 主引用文献 | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J.Med.Chem., 60, 2017
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5M25
| Modulation of MLL1 Methyltransferase Activity | 分子名称: | (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide, WD repeat-containing protein 5 | 著者 | Srinivasan, V. | 登録日 | 2016-10-11 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
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5M2N
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