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1O44
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Crystal structure of sh2 in complex with ru85052
分子名称: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4C
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.
分子名称: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4I
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219.
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O48
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.
分子名称: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4O
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE.
分子名称: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4Q
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256.
分子名称: PHENYL(SULFO)ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4N
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID.
分子名称: OXALIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4D
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.
分子名称: 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
著者Lange, G, Loenze, P, Liesum, A.
登録日2003-06-15
公開日2004-02-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1R1P
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Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads
分子名称: GRB2-related adaptor protein 2, LAT pY171 peptide, SULFATE ION
著者Cho, S, Mariuzza, R.A.
登録日2003-09-24
公開日2004-09-28
最終更新日2020-01-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
Embo J., 23, 2004
1R1Q
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Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads
分子名称: GRB2-related adaptor protein 2, LAT pY191 peptide, SULFATE ION
著者Cho, S, Mariuzza, R.A.
登録日2003-09-24
公開日2004-09-28
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
Embo J., 23, 2004
1R1S
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Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads
分子名称: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION
著者Cho, S, Mariuzza, R.A.
登録日2003-09-24
公開日2004-09-28
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
Embo J., 23, 2004
1RJA
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BU of 1rja by Molmil
Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain
分子名称: Tyrosine-protein kinase 6
著者Hong, E, Shin, J, Lee, W.
登録日2003-11-18
公開日2004-07-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution Structure and Backbone Dynamics of the Non-receptor Protein-tyrosine Kinase-6 Src Homology 2 Domain
J.Biol.Chem., 279, 2004
1RPY
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CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS
分子名称: SULFATE ION, adaptor protein APS
著者Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R.
登録日2003-12-03
公開日2003-12-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
1RQQ
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Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
分子名称: BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ...
著者Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R.
登録日2003-12-06
公開日2003-12-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
1UUS
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Structure of an activated Dictyostelium STAT in its DNA-unbound form
分子名称: STAT PROTEIN
著者Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W.
登録日2004-01-09
公開日2004-03-26
最終更新日2019-10-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form
Mol.Cell, 13, 2004
1UUR
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Structure of an activated Dictyostelium STAT in its DNA-unbound form
分子名称: STATA PROTEIN
著者Soler-Lopez, M, Petosa, C, Fukuzawa, M, Ravelli, R, Williams, J.G, Muller, C.W.
登録日2004-01-09
公開日2004-03-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of an Activated Dictyostelium Stat in its DNA-Unbound Form
Mol.Cell, 13, 2004
1XA6
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BU of 1xa6 by Molmil
Crystal Structure of the Human Beta2-Chimaerin
分子名称: Beta2-chimaerin, ZINC ION
著者Canagarajah, B, Leskow, F.C, Ho, J.Y, Mischak, H, Saidi, L.F, Kazanietz, M.G, Hurley, J.H.
登録日2004-08-25
公開日2004-11-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.
Cell(Cambridge,Mass.), 119, 2004
1WQU
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BU of 1wqu by Molmil
Solution structure of the human FES SH2 domain
分子名称: Proto-oncogene tyrosine-protein kinase FES/FPS
著者Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-10-02
公開日2005-06-14
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes
J.Biomol.NMR, 31, 2005
1Y1U
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Structure of unphosphorylated STAT5a
分子名称: Signal transducer and activator of transcription 5A
著者Neculai, D, Neculai, A.M, Verrier, S, Straub, K, Klumpp, K, Pfitzner, E, Becker, S.
登録日2004-11-19
公開日2005-10-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Structure of the unphosphorylated STAT5a dimer
J.Biol.Chem., 280, 2005
1Y57
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Structure of unphosphorylated c-Src in complex with an inhibitor
分子名称: 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION
著者Cowan-Jacob, S.W, Fendrich, G, Manley, P.W, Jahnke, W, Fabbro, D, Liebetanz, J, Meyer, T.
登録日2004-12-02
公開日2005-06-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation
Structure, 13, 2005
1YVL
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BU of 1yvl by Molmil
Structure of Unphosphorylated STAT1
分子名称: 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta
著者Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X.
登録日2005-02-16
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural bases of unphosphorylated STAT1 association and receptor binding.
Mol.Cell, 17, 2005
1Z3K
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Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain
分子名称: Cytoplasmic protein NCK2
著者Ran, X, Song, J.
登録日2005-03-14
公開日2005-03-29
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain.
J.Biol.Chem., 280, 2005
1X0N
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NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor
分子名称: 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2
著者Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F.
登録日2005-03-24
公開日2005-04-19
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor
To be Published
1X27
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Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas
分子名称: CRK-associated substrate, Proto-oncogene tyrosine-protein kinase LCK, SODIUM ION
著者Nasertorabi, F, Tars, K, Becherer, K, Kodandapani, R, Liljas, L, Vuori, K, Ely, K.R.
登録日2005-04-20
公開日2006-02-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis for regulation of Src by the docking protein p130Cas
J.MOL.RECOG., 19, 2006
1X6C
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Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1
分子名称: Tyrosine-protein phosphatase, non-receptor type 6
著者Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-17
公開日2005-11-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1
To be Published

221051

件を2024-06-12に公開中

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