8K1U
| Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, Ktr system potassium uptake protein B, ... | 著者 | Chang, Y.K, Chiang, W.T, Hu, N.J, Tsai, M.D. | 登録日 | 2023-07-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Structural basis and synergism of ATP and Na + activation in bacterial K + uptake system KtrAB. Nat Commun, 15, 2024
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8I5Y
| Structure of human Nav1.7 in complex with vixotrigine | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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6NUC
| Structure of Calcineurin in complex with NHE1 peptide | 分子名称: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wang, X, Page, R, Peti, W. | 登録日 | 2019-01-31 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
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6NUF
| Structure of Calcineurin in complex with NHE1 peptide | 分子名称: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wang, X, Page, R, Peti, W. | 登録日 | 2019-01-31 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
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8GZ1
| Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Sodium channel protein type 8 subunit alpha, ... | 著者 | Li, Y, Jiang, D. | 登録日 | 2022-09-24 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
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4U9O
| Crystal structure of NqrA from Vibrio cholerae | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Na(+)-translocating NADH-quinone reductase subunit A | 著者 | Fritz, G. | 登録日 | 2014-08-06 | 公開日 | 2014-12-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase. Nature, 516, 2014
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4U9S
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4UAJ
| Crystal structure of NqrF in hexagonal space group | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Na(+)-translocating NADH-quinone reductase subunit F, SULFATE ION | 著者 | Fritz, G. | 登録日 | 2014-08-10 | 公開日 | 2015-08-05 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7019 Å) | 主引用文献 | Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase. Nature, 516, 2014
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2OCV
| Structural basis of Na+ activation mimicry in murine thrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | 登録日 | 2006-12-21 | 公開日 | 2007-04-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin. J.Biol.Chem., 282, 2007
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7Z04
| 10 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | 分子名称: | BERYLLIUM TRIFLUORIDE ION, FXYD domain-containing ion transport regulator, MAGNESIUM ION, ... | 著者 | Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shasavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. | 登録日 | 2022-02-22 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (7.5 Å) | 主引用文献 | The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. J.Biol.Chem., 298, 2022
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7YZR
| 50 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | 分子名称: | BERYLLIUM TRIFLUORIDE ION, FXYD domain-containing ion transport regulator, MAGNESIUM ION, ... | 著者 | Fruergaard, M.U, Dach, I, Andersen, J.L, Ozol, M, Shasavar, A, Quistgaard, E.M, Poulsen, H, Fedosova, N.U, Nissen, P. | 登録日 | 2022-02-21 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (6.92 Å) | 主引用文献 | The Na + ,K + -ATPase in complex with beryllium fluoride mimics an ATPase phosphorylated state. J.Biol.Chem., 298, 2022
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8FAJ
| OXA-48-NA-1-157 inhibitor complex | 分子名称: | (5R)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... | 著者 | Smith, C.A, Stewart, N.K, Toth, M, Vakulenko, S.B. | 登録日 | 2022-11-28 | 公開日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases. Acs Infect Dis., 9, 2023
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5JAF
| LeuT Na+-free Return State, C2 form at pH 5 | 分子名称: | Transporter, octyl beta-D-glucopyranoside | 著者 | Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P. | 登録日 | 2016-04-12 | 公開日 | 2016-06-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.021 Å) | 主引用文献 | A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun, 7, 2016
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8I5G
| Structure of human Nav1.7 in complex with PF-05089771 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-25 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
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8IWO
| The rice Na+/H+ antiporter SOS1 in an auto-inhibited state | 分子名称: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl tetradecanoate, OsSOS1 | 著者 | Zhang, X.Y, Tang, L.H, Zhang, C.R, Nie, J.W. | 登録日 | 2023-03-30 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na + /H + antiporter. Nat.Plants, 9, 2023
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7X23
| Cryo-EM structure of non gastric H,K-ATPase alpha2 SPWC mutant in 3Na+E1-AMPPCPF state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Potassium-transporting ATPase alpha chain 2, ... | 著者 | Abe, K, Nakanishi, H, Young, V, Artigas, P. | 登録日 | 2022-02-25 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms. Nat Commun, 13, 2022
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7D91
| Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ (P4(3)2(1)2 symmetry) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | 登録日 | 2020-10-12 | 公開日 | 2021-01-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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7D92
| Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain (P4(3)2(1)2 symmetry) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C. | 登録日 | 2020-10-12 | 公開日 | 2021-01-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state. Proc.Natl.Acad.Sci.USA, 118, 2021
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5JAG
| LeuT T354H mutant in the outward-oriented, Na+-free Return State | 分子名称: | Transporter, octyl beta-D-glucopyranoside | 著者 | Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P. | 登録日 | 2016-04-12 | 公開日 | 2016-06-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun, 7, 2016
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3ZK2
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8FHR
| Cryo-EM structure of human NCC (class 3-3) | 分子名称: | Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera | 著者 | Zhang, J, Fan, M, Feng, L. | 登録日 | 2022-12-14 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614, 2023
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8FHO
| Cryo-EM structure of human NCC (class 1) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, SODIUM ION, ... | 著者 | Zhang, J, Fan, M, Feng, L. | 登録日 | 2022-12-14 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614, 2023
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8FHP
| Cryo-EM structure of human NCC (class 3-1) | 分子名称: | Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera | 著者 | Zhang, J, Fan, M, Feng, L. | 登録日 | 2022-12-14 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614, 2023
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8FHQ
| Cryo-EM structure of human NCC (class 3-2) | 分子名称: | Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera | 著者 | Zhang, J, Fan, M, Feng, L. | 登録日 | 2022-12-14 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614, 2023
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8XMH
| Potassium transporter KtrAB from Bacillus subtilis in ATP-bound state with addition of EDTA and EGTA, vertical C2 symmetry axis | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Ktr system potassium uptake protein A, Ktr system potassium uptake protein B, ... | 著者 | Chang, Y.K, Chiang, W.T, Hu, N.J, Tsai, M.D. | 登録日 | 2023-12-27 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis and synergism of ATP and Na + activation in bacterial K + uptake system KtrAB. Nat Commun, 15, 2024
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