PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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5V0N	BACE1 in complex with inhibitor 5g 分子名称: Beta-secretase 1, GLYCEROL, N-{(1S,2S)-1-[(2S)-4-benzyl-3-oxopiperazin-2-yl]-1-hydroxy-3-phenylpropan-2-yl}-7-ethyl-1,3,3-trimethyl-2,2-dioxo-1,2,3,4-tetrahydro-2lambda~6~-[1,2,5]thiadiazepino[3,4,5-hi]indole-9-carboxamide, ... 著者 Mesecar, A, Ghosh, A, Yen, Y.-C. 登録日 2017-02-28 公開日 2017-05-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.155 Å) 主引用文献 Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. Bioorg. Med. Chem. Lett., 27, 2017
4Y70	Yeast 20S proteasome in complex with Ac-LAV-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-LAV-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-13 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4Y8P	Yeast 20S proteasome beta7-delta7_Cter mutant in complex with Ac-PAL-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PAL-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4Y9Y	Yeast 20S proteasome beta2-H116E mutant 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, Proteasome subunit alpha type-1, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-17 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4YEK	X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with thymidine 分子名称: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... 著者 Balaev, V.V, Lashkov, A.A, Gabdulkhakov, A.G, Betzel, C, Mikhailov, A.M. 登録日 2015-02-24 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine. Acta Crystallogr.,Sect.F, 72, 2016
4YFX	Escherichia coli RNA polymerase in complex with Myxopyronin B 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.844 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
5URF	The structure of human bocavirus 1 分子名称: viral protein 3 著者 Mietzsch, M, Kailasan, S, Garrison, J, Ilyas, M, Chipman, P, Kandola, K, Jansen, M, Spear, J, Sousa, D, McKenna, R, Soderlund-Venermo, M, Baker, T, Agbandje-McKenna, M. 登録日 2017-02-10 公開日 2017-03-29 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural Insights into Human Bocaparvoviruses. J. Virol., 91, 2017
4YNM	ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM) 分子名称: Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION 著者 Rogawski, D.S, Ndoj, J, Cho, H.-J, Maillard, I, Grembecka, J, Cierpicki, T. 登録日 2015-03-10 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry, 54, 2015
4YU7	Crystal structure of Piratoxin I (PrTX-I) complexed to caffeic acid 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog piratoxin-1, CAFFEIC ACID, ... 著者 Fernandes, C.A.H, Fontes, M.R.M. 登録日 2015-03-18 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.647 Å) 主引用文献 Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids. Plos One, 10, 2015
4YA0	Yeast 20S proteasome beta2-H116E mutant in complex with Ac-PAE-ep 分子名称: Ac-PAE-ep, CHLORIDE ION, MAGNESIUM ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-17 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
5UTZ	Human IL-2/Fab complex 分子名称: Fab 5111 heavy chain, Fab 5111 light chain, GLYCEROL, ... 著者 Jude, K.M, Garcia, K.C. 登録日 2017-02-15 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.747 Å) 主引用文献 A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat. Med., 24, 2018
4Y75	Yeast 20S proteasome in complex with Ac-PAF-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PAF-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-13 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4Y8N	Yeast 20S proteasome beta7-delta7_Cter mutant in complex with Ac-PAE-ep 分子名称: Ac-PAE-ep, CHLORIDE ION, MAGNESIUM ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4Y69	Yeast 20S proteasome in complex with Ac-PAD-ep 分子名称: Ac-PAD-ep, CHLORIDE ION, MAGNESIUM ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-12 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4Y81	Yeast 20S proteasome in complex with Ac-PAY-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PAY-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4Y8Q	Yeast 20S proteasome beta7-delta7_Cter mutant in complex with Ac-PAY-ep 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ac-PAY-ep, CHLORIDE ION, ... 著者 Huber, E.M, Groll, M. 登録日 2015-02-16 公開日 2015-06-17 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. J.Am.Chem.Soc., 137, 2015
4YAK	Ca. Korarchaeum cryptofilum dinucleotide forming Acetyl-coenzyme A synthetase 1 in complex with coenzyme A, acetyl-coenzyme A and with phosphorylated phosphohistidine segment (site I orientation) 分子名称: ACETYL COENZYME *A, COENZYME A, alpha subunit of Acyl-CoA synthetase (NDP forming), ... 著者 Weisse, R.H.-J, Scheidig, A.J. 登録日 2015-02-17 公開日 2016-01-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.464 Å) 主引用文献 Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer. Proc.Natl.Acad.Sci.USA, 113, 2016
5VAL	BRAF in Complex with N-(3-(tert-butyl)phenyl)-4-methyl-3-(6-morpholinopyrimidin-4-yl)benzamide 分子名称: N-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide, Serine/threonine-protein kinase B-raf 著者 Mamo, M, Appleton, B.A. 登録日 2017-03-27 公開日 2017-06-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J. Med. Chem., 60, 2017
4YAJ	Ca. Korarchaeum cryptofilum dinucleotide forming Acetyl-coenzyme A synthetase 1 (apo form) 分子名称: SODIUM ION, alpha subunit of Acetyl-coenzyme A synthetase (dinucleotide-forming) 3, beta subunit of Acetyl-coenzyme A synthetase (dinucleotide-forming) 3 著者 Weisse, R.H.-J, Scheidig, A.J. 登録日 2015-02-17 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer. Proc.Natl.Acad.Sci.USA, 113, 2016
5UW7	PCY1 Y481F Variant in Complex with Follower Peptide 分子名称: MAGNESIUM ION, Peptide cyclase 1, Presegetalin A1 著者 Chekan, J.R, Nair, S.K. 登録日 2017-02-20 公開日 2017-05-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4Y3O	Crystal structure of Ribosomal oxygenase NO66 in complex with substrate Rpl8 peptide and Ni(II) and cofactor N-oxalyglycine 分子名称: ACETATE ION, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, GLYCEROL, ... 著者 Wang, C, Zhang, Q, Zang, J. 登録日 2015-02-10 公開日 2015-10-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D, 71, 2015
4Z3U	PRV nuclear egress complex 分子名称: CHLORIDE ION, SODIUM ION, UL31, ... 著者 Bigalke, J.M, Heldwein, E.E. 登録日 2015-03-31 公開日 2015-11-11 最終更新日 2019-12-11 実験手法 X-RAY DIFFRACTION (2.706 Å) 主引用文献 Structural basis of membrane budding by the nuclear egress complex of herpesviruses. Embo J., 34, 2015
4ZBL	Phototoxic fluorescent protein mKillerOrange 分子名称: CITRIC ACID, GLYCEROL, KillerOrange 著者 Pletnev, V.Z, Pletneva, N.V, Pletnev, S.V. 登録日 2015-04-14 公開日 2015-12-23 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Crystal Structure of Phototoxic Orange Fluorescent Proteins with a Tryptophan-Based Chromophore. Plos One, 10, 2015
5UHB	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with Rifampin 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.29 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
4Z7F	Crystal structure of FolT bound with folic acid 分子名称: FOLIC ACID, Folate ECF transporter 著者 Zhao, Q, Wang, C.C, Wang, C.Y, Zhang, P. 登録日 2015-04-07 公開日 2015-07-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.194 Å) 主引用文献 Structures of FolT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters Nat Commun, 6, 2015

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