PDB: 243531 件ウェブページステータス検索Chemie searchBIRD

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3NAX	PDK1 in complex with inhibitor MP7 分子名称: 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1 著者 Yan, Y, Munshi, S.K, Allison, T. 登録日 2010-06-02 公開日 2010-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor. J.Biol.Chem., 286, 2011
3CTB	Tethered PXR-LBD/SRC-1p apoprotein 分子名称: Pregnane X receptor, Linker, Steroid receptor coactivator 1 著者 Lesburg, C.A. 登録日 2008-04-11 公開日 2008-12-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability Protein Eng.Des.Sel., 21, 2008
1DJX	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-1,4,5-TRISPHOSPHATE 分子名称: ACETATE ION, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... 著者 Essen, L.-O, Perisic, O, Williams, R.L. 登録日 1996-08-24 公開日 1997-07-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C. Biochemistry, 36, 1997
3NBQ	Human uridine phosphorylase 1 (hUPP1) with 5-fluorouracil 分子名称: 5-FLUOROURACIL, Uridine phosphorylase 1 著者 Roosild, T.P. 登録日 2010-06-03 公開日 2010-10-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Active site conformational dynamics in human uridine phosphorylase 1. Plos One, 5, 2010
3CKR	Crystal structure of BACE-1 in complex with inhibitor 分子名称: (4S)-1,4-dibenzyl-N-[(1S,2R)-1-benzyl-3-{[3-(dimethylamino)benzyl]amino}-2-hydroxypropyl]-2-oxoimidazolidine-4-carboxamide, Beta-secretase 1 著者 Min, K. 登録日 2008-03-16 公開日 2008-06-03 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives Bioorg.Med.Chem.Lett., 18, 2008
3N6K	Human FPPS complex with NOV_823 分子名称: 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid, FARNESYL PYROPHOSPHATE SYNTHASE, PHOSPHATE ION 著者 Rondeau, J.-M. 登録日 2010-05-26 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP 分子名称: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N8S	Crystal Structure of BlaC-E166A covalently bound with Cefamandole 分子名称: (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION 著者 Tremblay, L.W, Blanchard, J.S. 登録日 2010-05-28 公開日 2010-11-24 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants. Biochemistry, 49, 2010
1J5J	Solution structure of HERG-specific scorpion toxin BeKm-1 分子名称: BeKm-1 toxin 著者 Korolokova, Y.V, Bocharov, E.V, Angelo, K, Maslennikov, I.V, Grinenko, O.V, Lipkin, A.V, Nosireva, E.D, Pluzhnikov, K.A, Olesen, S.-P, Arseniev, A.S, Grishin, E.V. 登録日 2002-04-16 公開日 2002-11-20 最終更新日 2024-10-16 実験手法 SOLUTION NMR 主引用文献 New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1. J.Biol.Chem., 277, 2002
3TNN	Crystal structure of N5-i5 Fab, an ADCC mediating and non-neutralizing CD4i anti-HIV- 1 antibody. 分子名称: CHLORIDE ION, Fab heavy chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5, Fab light chain of ADCC and non-neutralizing anti-HIV-1 antibody N5-i5, ... 著者 Wu, X, Pazgier, M. 登録日 2011-09-01 公開日 2012-09-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of N5-i5 Fab, an ADCC and non-neutralizing anti-HIV-1 antibody To be Published
1INV	A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES 分子名称: (1R)-4-acetamido-1,5-anhydro-2,4-dideoxy-1-phosphono-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 White, C.L, Janakiraman, M.N, Laver, W.G, Philippon, C, Vasella, A, Air, G.M, Luo, M. 登録日 1994-09-26 公開日 1995-02-07 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies. J.Mol.Biol., 245, 1995
4EQI	Crystal structure of serratia fonticola carbapenemase SFC-1 分子名称: 1,2-ETHANEDIOL, Carbapenem-hydrolizing beta-lactamase SFC-1, SODIUM ION 著者 Fonseca, F, Spencer, J. 登録日 2012-04-18 公開日 2012-05-23 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations. J.Am.Chem.Soc., 134, 2012
1EBH	OCTAHEDRAL COORDINATION AT THE HIGH AFFINITY METAL SITE IN ENOLASE; CRYSTALLOGRAPHIC ANALYSIS OF THE MG++-ENZYME FROM YEAST AT 1.9 ANGSTROMS RESOLUTION 分子名称: CHLORIDE ION, ENOLASE, MAGNESIUM ION 著者 Wedekind, J.E, Reed, G.H, Rayment, I. 登録日 1994-11-01 公開日 1995-04-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Octahedral coordination at the high-affinity metal site in enolase: crystallographic analysis of the MgII--enzyme complex from yeast at 1.9 A resolution. Biochemistry, 34, 1995
2O2D	Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with citrate 分子名称: CITRIC ACID, GLYCEROL, Glucose-6-phosphate isomerase, ... 著者 Arsenieva, D, Mazock, G.H, Appavu, B.L, Jeffery, C.J. 登録日 2006-11-29 公開日 2007-11-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution Proteins, 74, 2008
2ESX	The structure of the V3 region within gp120 of JR-FL HIV-1 strain (minimized average structure) 分子名称: Envelope polyprotein GP160 著者 Rosen, O, Sharon, M, Samson, A.O, Quadt, S.R, Anglister, J. 登録日 2005-10-27 公開日 2006-09-19 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Molecular switch for alternative conformations of the HIV-1 V3 region: Implications for phenotype conversion. Proc.Natl.Acad.Sci.Usa, 13, 2006
2ESZ	The structure of the V3 region within gp120 of JR-FL HIV-1 strain (ensemble) 分子名称: Envelope polyprotein GP160 著者 Rosen, O, Sharon, M, Samson, A.O, Quadt, S.R, Anglister, J. 登録日 2005-10-27 公開日 2006-09-19 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Molecular switch for alternative conformations of the HIV-1 V3 region: Implications for phenotype conversion. Proc.Natl.Acad.Sci.Usa, 13, 2006
1XM2	Crystal structure of Human PRL-1 分子名称: SULFATE ION, Tyrosine Phosphatase 著者 Jeong, D.G, Kim, S.J, Kim, J.H, Son, J.H, Ryu, S.E. 登録日 2004-10-01 公開日 2005-01-25 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms J.Mol.Biol., 345, 2005
3BCS	Glycogen Phosphorylase complex with 1(-D-glucopyranosyl) uracil 分子名称: 1-beta-D-glucopyranosylpyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form 著者 Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. 登録日 2007-11-13 公開日 2008-11-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
4L41	Human Lactose synthase: A 2:1 complex between human alpha-lactalbumin and human beta1,4-galactosyltransferase 分子名称: Alpha-lactalbumin, Beta-1,4-galactosyltransferase 1, CALCIUM ION, ... 著者 Ramakrishnan, B, Qasba, P.K. 登録日 2013-06-07 公開日 2013-10-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of Human Lactose Synthase forms a Novel 1:2 Complex between beta1,4Galactosyltransferase 1 and alpha-Lactalbumin Proteins To be Published
3TKU	MRCK beta in complex with fasudil 分子名称: 1,2-ETHANEDIOL, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, Serine/threonine-protein kinase MRCK beta 著者 Heikkila, T.J, Turnbull, A, Wheatley, E, Schroder, E, Crighton, D, Olson, M.F. 登録日 2011-08-29 公開日 2011-10-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Co-crystal structures of inhibitors with MRCK, a key regulator of tumor cell invasion Plos One, 6, 2011
3BJF	Pyruvate kinase M2 is a phosphotyrosine binding protein 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, OXALATE ION, ... 著者 Wu, N. 登録日 2007-12-03 公開日 2008-03-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature, 452, 2008
4PS3	Structure of PI3K gamma in complex with 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea 分子名称: 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Griffith, J.P. 登録日 2014-03-06 公開日 2014-05-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase gamma. J.Med.Chem., 58, 2015
1G3L	THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). TDP-L-RHAMNOSE COMPLEX. 分子名称: 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE, GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, SULFATE ION 著者 Blankenfeldt, W, Asuncion, M, Lam, J.S, Naismith, J.H. 登録日 2000-10-24 公開日 2000-12-27 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA). EMBO J., 19, 2000
2FCY	HIV-1 DIS kissing-loop in complex with Neomycin 分子名称: CHLORIDE ION, HIV-1 DIS RNA, NEOMYCIN, ... 著者 Ennifar, E, Paillart, J.C, Marquet, R, Dumas, P. 登録日 2005-12-13 公開日 2006-05-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell. Nucleic Acids Res., 34, 2006
3RL9	Crystal Structure of the complex of type I RIP with the hydrolyzed product of dATP, adenine at 1.9 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, GLYCEROL, ... 著者 Kushwaha, G.S, Pandey, N, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. 登録日 2011-04-19 公開日 2011-05-11 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states Biochim.Biophys.Acta, 1824, 2012

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