PDB: 20505 件ウェブページステータス検索Chemie searchBIRD

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4ZBI	Mcl-1 complexed with small molecules 分子名称: 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 著者 Zhao, B. 登録日 2015-04-14 公開日 2015-04-29 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. J.Med.Chem., 58, 2015
3EAZ	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-26 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
3GIN	Crystal structure of E454K-CBD1 分子名称: CALCIUM ION, Sodium/calcium exchanger 1 著者 Chaptal, V, Mercado-Besserer, G, Abramson, J. 登録日 2009-03-05 公開日 2009-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and functional analysis of a Ca2+ sensor mutant of the na+/ca2+ exchanger J.Biol.Chem., 284, 2009
3FHO	Structure of S. pombe Dbp5 分子名称: ATP-dependent RNA helicase dbp5 著者 Cheng, Z, Song, H. 登録日 2008-12-09 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Solution and crystal structures of mRNA exporter Dbp5p and its interaction with nucleotides J.Mol.Biol., 388, 2009
4A55	Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PIK-108 著者 Hon, W.-C, Berndt, A, Williams, R.L. 登録日 2011-10-24 公開日 2011-12-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases. Oncogene, 31, 2012
3GAU	Solution structure of Human Complement Factor H in 50 mM NaCl buffer 分子名称: Complement factor H 著者 Okemefuna, A.I, Nan, R, Gor, J, Perkins, S.J. 登録日 2009-02-18 公開日 2009-06-09 最終更新日 2024-02-21 実験手法 SOLUTION SCATTERING 主引用文献 Electrostatic interactions contribute to the folded-back conformation of wild type human factor H. J.Mol.Biol., 391, 2009
8EZD	Brain-derived 42-residue amyloid-beta fibril type A 分子名称: Beta-amyloid protein 42 著者 Tycko, R, Lee, M, Yau, Y.-M, Louis, J.M. 登録日 2022-10-31 公開日 2023-03-22 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions. Proc.Natl.Acad.Sci.USA, 120, 2023
8EZE	Brain-derived 42-residue amyloid-beta fibril type B 分子名称: Beta-amyloid protein 42 著者 Tycko, R, Lee, M, Yau, Y.-M, Louis, J.M. 登録日 2022-10-31 公開日 2023-03-22 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions. Proc.Natl.Acad.Sci.USA, 120, 2023
3GGW	Crystal Structure of FAB F22-4 in complex with a Carbohydrate-mimetic peptide 分子名称: FAB F22-4 HEAVY CHAIN, FAB F22-4 LIGHT CHAIN, PEPTIDE B1 著者 Saul, F.A, Vulliez-Le Normand, B, Bentley, G.A. 登録日 2009-03-02 公開日 2009-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Mimicry of O-Antigen by a Peptide Revealed in a Complex with an Antibody Raised against Shigella flexneri Serotype 2a J.Mol.Biol., 388, 2009
3GAV	Solution structure of Human Complement Factor H in 137 mM NaCl buffer 分子名称: Complement factor H 著者 Okemefuna, A.I, Nan, R, Gor, J, Perkins, S.J. 登録日 2009-02-18 公開日 2009-06-09 最終更新日 2024-02-21 実験手法 SOLUTION SCATTERING 主引用文献 Electrostatic interactions contribute to the folded-back conformation of wild type human factor H. J.Mol.Biol., 391, 2009
3GAW	Solution structure of Human Complement Factor H in 250 mM NaCl buffer 分子名称: Complement factor H 著者 Okemefuna, A.I, Nan, R, Gor, J, Perkins, S.J. 登録日 2009-02-18 公開日 2009-06-09 最終更新日 2024-02-21 実験手法 SOLUTION SCATTERING 主引用文献 Electrostatic interactions contribute to the folded-back conformation of wild type human factor H. J.Mol.Biol., 391, 2009
3HQB	Crystal structure of human desarg-C5A 分子名称: Complement C5 著者 Cook, W.J, Ealick, S.E. 登録日 2009-06-05 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.299 Å) 主引用文献 Structure of human desArg-C5a. Acta Crystallogr.,Sect.D, 66, 2010
3HQA	Crystal structure of human desarg-C5A 分子名称: Complement C5 著者 Cook, W.J, Ealick, S.E. 登録日 2009-06-05 公開日 2010-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.586 Å) 主引用文献 Structure of human desArg-C5a. Acta Crystallogr.,Sect.D, 66, 2010
4AGW	Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromet hyl)phenyl}benzamide, GLYCEROL, ... 著者 Weisberg, E, Choi, H.G, Seeliger, M, Gray, N, Griffin, J.D. 登録日 2012-02-01 公開日 2012-02-15 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of Bcr-Abl, Pdgfralpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. Blood, 115, 2010
3EAC	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), Oxidized form. 分子名称: Tyrosine-protein kinase CSK 著者 Liu, D, Seidel, R.D, Cowburn, D. 登録日 2008-08-25 公開日 2009-11-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
3LNX	Second PDZ domain from human PTP1E 分子名称: IODIDE ION, THIOCYANATE ION, Tyrosine-protein phosphatase non-receptor type 13 著者 Zhang, J, Chang, A, Ke, H, Phillips Jr, G.N, Lee, A.L, Center for Eukaryotic Structural Genomics (CESG) 登録日 2010-02-03 公開日 2010-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.642 Å) 主引用文献 Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry, 49, 2010
3E0U	Crystal structure of T. cruzi GPX1 分子名称: AMMONIUM ION, GLYCEROL, Glutathione peroxidase 著者 Patel, S.H, Hussain, S, Harris, R, Driscoll, P, Djordjevic, S. 登録日 2008-08-01 公開日 2009-08-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). Biochem.J., 425, 2010
6R3M	Family 11 Carbohydrate-Binding Module from Clostridium thermocellum in complex with beta-1,3-1,4-mixed-linked tetrasaccharide 分子名称: ACETATE ION, CALCIUM ION, Endoglucanase H, ... 著者 Ribeiro, D.O, Carvalho, A.L. 登録日 2019-03-20 公開日 2020-02-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Molecular basis for the preferential recognition of beta 1,3-1,4-glucans by the family 11 carbohydrate-binding module from Clostridium thermocellum. Febs J., 287, 2020
6R4W	Crystal structure of apo PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVNAPVP-CONH2 分子名称: ACE-GLU-VAL-ASN-ALA-PRO-VAL-LPD, Pro-Pro endopeptidase, ZINC ION 著者 Pichlo, C, Baumann, U. 登録日 2019-03-24 公開日 2019-06-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.391 Å) 主引用文献 Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
6R56	Crystal structure of PPEP-1(K101E/E184K) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION 著者 Pichlo, C, Baumann, U. 登録日 2019-03-24 公開日 2019-06-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
6R4Z	Crystal structure of holo PPEP-1(E143A/Y178F) in complex with product peptide Ac-EVNP-CO2 (substrate peptide: Ac-EVNPPVP-CONH2) 分子名称: ACE-GLU-VAL-ASN-PRO, NICKEL (II) ION, Pro-Pro endopeptidase, ... 著者 Pichlo, C, Baumann, U. 登録日 2019-03-24 公開日 2019-06-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.052 Å) 主引用文献 Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
6R59	Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVAPPVP-NH2 分子名称: ACE-GLU-VAL-ALA-PRO-PRO-VAL-LPD, Pro-Pro endopeptidase, ZINC ION 著者 Pichlo, C, Baumann, U. 登録日 2019-03-24 公開日 2019-06-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1. J.Biol.Chem., 294, 2019
6LF1	SeviL, a GM1b/asialo-GM1 binding lectin 分子名称: CHLORIDE ION, SeviL 著者 Kamata, K, Ozeki, Y, Park, S.-Y, Tame, J.R.H. 登録日 2019-11-28 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The structure of SeviL, a GM1b/asialo-GM1 binding R-type lectin from the mussel Mytilisepta virgata. Sci Rep, 10, 2020
5HS7	Reduced form of the transcriptional regulator YodB from B. subtilis 分子名称: GLYCEROL, HTH-type transcriptional regulator YodB 著者 Lee, S.J, Lee, I.G, Lee, B.J. 登録日 2016-01-25 公開日 2016-08-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Two distinct mechanisms of transcriptional regulation by the redox sensor YodB Proc.Natl.Acad.Sci.USA, 113, 2016
6R36	T. brucei farnesyl pyrophosphate synthase (FPPS) 分子名称: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. 登録日 2019-03-19 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase. Chembiochem, 21, 2020

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