PDB: 1957 件ウェブページステータス検索Chemie searchBIRD

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2JDQ	C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5 分子名称: IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC PROTEIN 2 著者 Tarendeau, F, Guilligay, D, Mas, P, Boulo, S, Baudin, F, Ruigrok, R.W.H, Hart, D.J, Cusack, S. 登録日 2007-01-11 公開日 2007-02-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit Nat.Struct.Mol.Biol., 14, 2007
5TWN	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, NS5B RNA- DEPENDENT RNA POLYMERASE, ... 著者 Sheriff, S. 登録日 2016-11-14 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase. Medchemcomm, 8, 2017
2VQZ	Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, POLYMERASE BASIC PROTEIN 2 著者 Guilligay, D, Tarendeau, F, Resa-Infante, P, Coloma, R, Crepin, T, Sehr, P, Lewis, J, Ruigrok, R.W.H, Ortin, J, Hart, D.J, Cusack, S. 登録日 2008-03-21 公開日 2008-05-13 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2. Nat.Struct.Mol.Biol., 15, 2008
6NUS	SARS-Coronavirus NSP12 bound to NSP8 co-factor 分子名称: NSP12, NSP8, ZINC ION 著者 Kirchdoerfer, R.N, Ward, A.B. 登録日 2019-02-01 公開日 2019-05-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. Nat Commun, 10, 2019
6NUR	SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors 分子名称: NSP12, NSP7, NSP8, ... 著者 Kirchdoerfer, R.N, Ward, A.B. 登録日 2019-02-01 公開日 2019-05-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. Nat Commun, 10, 2019
4NCM	Influenza polymerase basic protein 2 (PB2) bound to a small-molecule inhibitor 分子名称: N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide, Polymerase basic protein 2 著者 Jacobs, M.D. 登録日 2013-10-24 公開日 2014-07-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2. J.Med.Chem., 57, 2014
2O5D	Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study 分子名称: (2S)-2-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)-2-(4-FLUOROPHENYL)-N-[(4-NITROPHENYL)SULFONYL]ACETAMIDE, HCV 著者 Yao, N. 登録日 2006-12-05 公開日 2007-02-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study. Bioorg.Med.Chem.Lett., 17, 2007
1QJU	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP61209 分子名称: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2N-METHYL-2H-TETRAZOL-5-YL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... 著者 Hadfield, A.T, Minor, I, Diana, G.D, Rossmann, M.G. 登録日 1999-07-05 公開日 1999-07-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
1QJY	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP65099 分子名称: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2-METHYL-4-ISOXAZOLYL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... 著者 Hadfield, A.T, Diana, G.D, Rossmann, M.G. 登録日 1999-07-06 公開日 1999-07-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
7K9Y	GsI-IIC RT Template-Switching Complex (twinned) 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*TP*CP*CP*AP*GP*GP*CP*AP*AP*C)-3'), MAGNESIUM ION, ... 著者 Stamos, J.L, Lentzsch, A.M. 登録日 2020-09-29 公開日 2021-08-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase. J.Biol.Chem., 297, 2021
5U0B	Structure of full-length Zika virus NS5 分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Zhao, B, Du, F. 登録日 2016-11-23 公開日 2017-03-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and function of the Zika virus full-length NS5 protein. Nat Commun, 8, 2017
1NB7	HC-J4 RNA polymerase complexed with short RNA template strand 分子名称: 5'-R(*UP*UP*UP*U)-3', MANGANESE (II) ION, polyprotein 著者 O'Farrell, D.J, Trowbridge, R, Rowlands, D.J, Jaeger, J. 登録日 2002-12-02 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
5N8X	Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus 分子名称: 3D polymerase, GLYCEROL, MANGANESE (II) ION 著者 Ferrer-Orta, C, Verdaguer, N. 登録日 2017-02-24 公開日 2017-05-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
1NB4	HC-J4 RNA polymerase apo-form 分子名称: polyprotein 著者 Jaeger, J, O'Farrell, D.J, Trowbridge, R, Rowlands, D.J. 登録日 2002-12-02 公開日 2003-03-25 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
1NB6	HC-J4 RNA polymerase complexed with UTP 分子名称: MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE, polyprotein 著者 O'Farrell, D.J, Trowbridge, R, Rowlands, D.J, Jaeger, J. 登録日 2002-12-02 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
1MUK	reovirus lambda3 native structure 分子名称: MINOR CORE PROTEIN LAMBDA 3 著者 Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. 登録日 2002-09-24 公開日 2002-12-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 RNA Synthesis in a Cage-Structural Studies of Reovirus Polymerase lambda3 Cell(Cambridge,Mass.), 111, 2002
5N95	Tetragonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus 分子名称: 3D polymerase, TRIPHOSPHATE 著者 Ferrer-Orta, C, Verdaguer, N. 登録日 2017-02-24 公開日 2017-05-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
7UIG	Mediator-PIC Early (Mediator A) 分子名称: DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-29 公開日 2023-02-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
5IQ6	Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new pyridobenzothizole inhibitor 分子名称: N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine, RNA dependent RNA polymerase, ZINC ION 著者 Tarantino, D, Mastrangelo, E, Milani, M. 登録日 2016-03-10 公開日 2016-10-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res., 134, 2016
6UEB	Structure of Rabies SAD-B19 L-P complex from cryo-EM 分子名称: Large structural protein, Phosphoprotein,Phosphoprotein, ZINC ION 著者 Horwitz, J.A, Harrison, S.C. 登録日 2019-09-20 公開日 2020-02-05 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure of a rabies virus polymerase complex from electron cryo-microscopy. Proc.Natl.Acad.Sci.USA, 117, 2020
6YP5	Solution NMR structure of the oligomerization domain of respiratory syncytial virus phosphoprotein 分子名称: Phosphoprotein 著者 Cardone, C, Bontems, F, Bardiaux, B, Sizun, C. 登録日 2020-04-15 公開日 2021-04-28 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein. Biomolecules, 11, 2021
8G6R	Porcine epidemic diarrhea virus core polymerase complex 分子名称: RNA (5'-R(P*AP*AP*GP*AP*AP*GP*CP*UP*AP*UP*UP*AP*AP*AP*AP*UP*CP*AP*CP*A)-3'), RNA (5'-R(P*GP*GP*UP*UP*GP*UP*GP*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*U)-3'), ZINC ION, ... 著者 Anderson, T.K, Kirchdoerfer, R.N. 登録日 2023-02-15 公開日 2023-03-29 最終更新日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 An alphacoronavirus polymerase structure reveals conserved co-factor functions. Biorxiv, 2023
8CXI	Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy 分子名称: A11 heavy chain, A11 light chain, Ankyrin repeat family A protein 2,Envelope E protein, ... 著者 Liu, W, Zhang, X.K, Gong, D.Y, Dai, X.H, Sharma, A, Zhang, T.H, Rey, F, Zhou, Z.H. 登録日 2022-05-21 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of Zika Virus in Complex with Antibodies Targeting E Dimer Epitopes and Basis for Neutralization Efficacy To Be Published
8T12	Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered. 分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION 著者 Biswal, M, Lu, J, Song, J. 登録日 2023-06-01 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 ordered. To Be Published
8T13	Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered 分子名称: Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION 著者 Biswal, M, Lu, J, Song, J. 登録日 2023-06-01 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Cryo-EM structure of DENV2 NS5 in complex with human STAT2 with the N-terminal domain of STAT2 disordered To Be Published

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