DNA Stretching in the Nucleosome Facilitates Alkylation by an Intercalating Antitumor Agent

Summary for 3KUY

DescriptorHistone H3.2, Histone H4, Histone H2A, ... (8 entities in total)
Functional Keywordsnucleosome, chromatin, dna stretching, intercalation, alkylation, chromosomal protein, dna-binding, methylation, nucleosome core, nucleus, structural protein-dna complex, structural protein/dna
Biological sourceXenopus laevis (African clawed frog)
Cellular locationNucleus Q6AZJ8 Q92130
Nucleus (By similarity) 3KUY 3KUY
Total number of polymer chains10
Total molecular weight196764.46
Wu, B.,Davey, C.A. (deposition date: 2009-11-28, release date: 2010-01-05, Last modification date: 2011-07-13)
Primary citation
Davey, G.E.,Wu, B.,Dong, Y.,Surana, U.,Davey, C.A.
DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent
Nucleic Acids Res., 38:2081-2088, 2010
PubMed: 20026584 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkp1174
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27260.7%5.7%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution