3KUY
DNA Stretching in the Nucleosome Facilitates Alkylation by an Intercalating Antitumor Agent
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3.2 | polymer | 135 | 15303.9 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 3 | C, G (C, G) | Histone H2A | polymer | 119 | 12941.1 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (D, H) | Histone H2B | polymer | 125 | 13848.1 | 2 | UniProt (Q92130) Pfam (PF00125) UniProt (by SIFTS) (P02281) | Xenopus laevis (African clawed frog) | |
| 5 | I (I) | DNA (145-MER) | polymer | 145 | 44749.7 | 1 | |||
| 6 | J (J) | DNA (145-MER) | polymer | 145 | 44740.6 | 1 | |||
| 7 | K (E) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 8 | L, M (I, J) | 2-[(2R)-oxiran-2-ylmethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione | non-polymer | 253.3 | 2 | Chemie (ATV) |
Sequence modifications
A, E: 1 - 135 (UniProt: P84233)
D, H: -2 - 122 (UniProt: Q92130)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Gly 103 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Glu -1 | Asp 3 | SEE REMARK 999 |
| Pro 7 | Ala 11 | SEE REMARK 999 |
| Thr 29 | Ser 33 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 196203.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 561.4 | |
| All* | Total formula weight | 196764.5 |
