PDB: 72236 件ウェブページステータス検索Chemie searchBIRD

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4QKW	Crystal structure of the zebrafish cavin4a HR1 domain 分子名称: CHLORIDE ION, Muscle-related coiled-coil protein 著者 Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. 登録日 2014-06-10 公開日 2015-03-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into the organization of the cavin membrane coat complex Dev.Cell, 31, 2014
2OOA	crystal structure of the UBA domain from Cbl-b ubiquitin ligase 分子名称: E3 ubiquitin-protein ligase CBL-B 著者 Kozlov, G, Gehring, K. 登録日 2007-01-25 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Mol.Cell, 27, 2007
4D43	Crystal structure of S. aureus FabI in complex with NADP and 2-(2- chloro-4-nitrophenoxy)-5-ethyl-4-fluorophenol 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(2-chloro-4-nitrophenoxy)-5-ethyl-4-fluorophenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], ... 著者 Schiebel, J, Chang, A, Tonge, P.J, Sotriffer, C.A, Kisker, C. 登録日 2014-10-26 公開日 2015-03-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction. Biochemistry, 54, 2015
6VU5	Structure of G-alpha-q bound to its chaperone Ric-8A 分子名称: Guanine nucleotide-binding protein G(q) subunit alpha, Resistance to inhibitors of cholinesterase-8A (Ric-8A) 著者 Seven, A.B, Hilger, D. 登録日 2020-02-14 公開日 2020-03-18 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of G alpha Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms. Cell Rep, 30, 2020
4DUS	Structure of Bace-1 (Beta-Secretase) in complex with N-((2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)butan-2-yl)acetamide 分子名称: Beta-secretase 1, GLYCEROL, IODIDE ION, ... 著者 Sickmier, E.A. 登録日 2012-02-22 公開日 2012-10-10 最終更新日 2014-07-02 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase. ACS Med Chem Lett, 3, 2012
4QVX	Discovery of a Potent and Selective BCL-XL Inhibitor That Demonstrates Thrombocytopenia and Inhibits Tumor Growth in Vivo 分子名称: 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-(3-{4-[3-(dimethylamino)prop-1-yn-1-yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1 著者 Park, C.H. 登録日 2014-07-16 公開日 2015-07-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS MED.CHEM.LETT., 5, 2014
6EL9	Glucocorticoid Receptor in complex with AZD9567 分子名称: 1,2-ETHANEDIOL, 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide, Glucocorticoid receptor, ... 著者 Edman, K, Wissler, L. 登録日 2017-09-28 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J. Med. Chem., 61, 2018
4EFI	Crystal Structure of 3-oxoacyl-(Acyl-carrier protein) Synthase from Burkholderia Xenovorans LB400 分子名称: 3-oxoacyl-(Acyl-carrier protein) synthase, CHLORIDE ION, FORMIC ACID, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Craig, T.K, Abendroth, J, Staker, B, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-29 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
4ENZ	Structure of human ceruloplasmin at 2.6 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ... 著者 Samygina, V.R, Sokolov, A.V, Bourenkov, G, Vasilyev, V.B, Bartunik, H. 登録日 2012-04-13 公開日 2013-04-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins. Plos One, 8, 2013
4EUI	Crystal Structure of MIF L46F mutant 分子名称: Macrophage migration inhibitory factor, SULFATE ION 著者 Ashrafi, A, Pojer, F, Lashuel, H. 登録日 2012-04-25 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
8OFD	Crystal structure of beta-conglutin from Lupinus albus refined to 2.81 A 分子名称: ACETATE ION, Conglutin beta 1, POTASSIUM ION, ... 著者 Dolot, R.M, O'Sullivan, C.K, Jauset-Rubio, M. 登録日 2023-03-15 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 First crystal structure of beta-conglutin, a major lupin allergen from Lupinus albus seeds To Be Published
2PUQ	Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor 分子名称: CALCIUM ION, Coagulation factor VII, TRP-TYR-THR-ARG CHLOROMETHYLKETONE INHIBITOR, ... 著者 Bjelke, J.R, Rasmussen, H.B. 登録日 2007-05-09 公開日 2007-05-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa Biochem.J., 405, 2007
4EPP	Canonical poly(ADP-ribose) glycohydrolase from Tetrahymena thermophila. 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Poly(ADP-ribose) glycohydrolase 著者 Dunstan, M.S, Leys, D. 登録日 2012-04-17 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase. Nat Commun, 3, 2012
4D42	Crystal structure of S. aureus FabI in complex with NADP and 4-fluoro- 5-hexyl-2-phenoxyphenol 分子名称: 4-fluoro-5-hexyl-2-phenoxyphenol, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, ... 著者 Schiebel, J, Chang, A, Tonge, P.J, Sotriffer, C.A, Kisker, C. 登録日 2014-10-26 公開日 2015-03-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction. Biochemistry, 54, 2015
2OJF	Crystal structure of Protein Kinase A in complex with Pyridine-Pyrazolopyridine based inhibitors 分子名称: (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, Inhibitory peptide, cAMP-dependent protein kinase, ... 著者 Stoll, V.S. 登録日 2007-01-12 公開日 2007-03-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt. Bioorg.Med.Chem., 15, 2007
4R7I	Crystal structure of FMS kinase domain with a small molecular inhibitor, GLEEVEC 分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Macrophage colony-stimulating factor 1 receptor 著者 Zhang, Y, Zhang, C. 登録日 2014-08-27 公開日 2015-08-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med, 373, 2015
4R8U	S-SAD structure of DINB-DNA Complex 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA, DNA polymerase IV, ... 著者 Kottur, J, Nair, D.T, Weinert, T, Oligeric, V, Wang, M. 登録日 2014-09-03 公開日 2015-01-14 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Fast native-SAD phasing for routine macromolecular structure determination Nat.Methods, 12, 2015
2OKJ	The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67) 分子名称: 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID, GAMMA-AMINO-BUTANOIC ACID, Glutamate decarboxylase 1 著者 Buckle, A.M, Fenalti, G, Law, R.H.P, Whisstock, J.C. 登録日 2007-01-17 公開日 2007-03-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat.Struct.Mol.Biol., 14, 2007
2OBE	Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, DIHYDROGENPHOSPHATE ION, Hexon protein 著者 Xue, F, Rux, J.J, Burnett, R.M. 登録日 2006-12-18 公開日 2007-07-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based identification of a major neutralizing site in an adenovirus hexon J.Virol., 81, 2007
6G27	X-ray structure of NSD3-PWWP1 in complex with compound 5 分子名称: 5-methyl-6-phenyl-2-piperidin-4-yl-pyridazin-3-one, Histone-lysine N-methyltransferase NSD3 著者 Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A. 登録日 2018-03-22 公開日 2019-06-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol., 15, 2019
4CSO	The structure of OrfY from Thermoproteus tenax 分子名称: ORFY PROTEIN, TRANSCRIPTION FACTOR 著者 Zeth, K, Hagemann, A, Siebers, B, Martin, J, Lupas, A.N. 登録日 2014-03-09 公開日 2014-03-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10. Proteins, 82 Suppl 2, 2014
4A5P	Structure of the Shigella flexneri MxiA protein 分子名称: 1,2-ETHANEDIOL, PROTEIN MXIA 著者 Abrusci, P, Vegara-Irigaray, M, Johnson, S, Roversi, P, Friede, M.E, Deane, J.E, Tang, C.M, Lea, S.M. 登録日 2011-10-26 公開日 2012-11-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Architecture of the major component of the type III secretion system export apparatus. Nat.Struct.Mol.Biol., 20, 2013
4DWQ	RNA ligase RtcB-GMP/Mn(2+) complex 分子名称: GLYCEROL, GUANOSINE-5'-MONOPHOSPHATE, MALONATE ION, ... 著者 Okada, C, Xia, S, Englert, M, Yao, M, Soll, D, Wang, J. 登録日 2012-02-26 公開日 2012-09-05 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc.Natl.Acad.Sci.USA, 109, 2012
4RSU	Crystal structure of the light and hvem complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... 著者 Liu, W, Ramagoal, U.A, Himmel, D, Bonanno, J.B, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) 登録日 2014-11-11 公開日 2015-02-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. J.Exp.Med., 218, 2021
4RUM	Crystal structure of the NiCo transition-metal riboswitch bound to cobalt 分子名称: COBALT (II) ION, GLYCEROL, MAGNESIUM ION, ... 著者 Ramesh, A, Winkler, W.C. 登録日 2014-11-21 公開日 2015-04-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6426 Å) 主引用文献 Bacterial riboswitches cooperatively bind Ni(2+) or Co(2+) ions and control expression of heavy metal transporters. Mol.Cell, 57, 2015

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