The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)

Summary for 2OKJ

DescriptorGlutamate decarboxylase 1, GAMMA-AMINO-BUTANOIC ACID, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID, ... (4 entities in total)
Functional Keywordsplp-dependent decarboxylase, lyase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight115307.78
Buckle, A.M.,Fenalti, G.,Law, R.H.P.,Whisstock, J.C. (deposition date: 2007-01-17, release date: 2007-03-27, Last modification date: 2011-07-13)
Primary citation
Fenalti, G.,Law, R.H.P.,Buckle, A.M.,Langendorf, C.,Tuck, K.,Rosado, C.J.,Faux, N.G.,Mahmood, K.,Hampe, C.S.,Banga, J.P.,Wilce, M.,Schmidberger, J.,Rossjohn, J.,El-Kabbani, O.,Pike, R.N.,Smith, A.I.,Mackay, I.R.,Rowley, M.J.,Whisstock, J.C.
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14:280-286, 2007
PubMed: 17384644 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb1228
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21770.9%5.0%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2okj
no rotation
Molmil generated image of 2okj
rotated about x axis by 90°
Molmil generated image of 2okj
rotated about y axis by 90°
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