8K9U
 
 | | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 2 (ADKI2) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LYSINE, Lysine--tRNA ligase, ... | | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | | 登録日 | 2023-08-01 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
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8QJM
 | | SmNuc1 nuclease from Stenotrophomonas maltophilia in complex with cytidine-5'-monophosphate | | 分子名称: | CYTIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, S1/P1 Nuclease, ... | | 著者 | Adamkova, K, Koval, T, Kolenko, P, Dohnalek, J. | | 登録日 | 2023-09-13 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study.
Febs J., 2024
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7ORS
 | | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147 | | 分子名称: | (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... | | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | | 登録日 | 2021-06-06 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove
To Be Published
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7MHW
 | | Crystal structure of the protease inhibitor U-Omp19 from Brucella abortus fused to Maltose-binding protein | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Outer membrane lipoprotein omp19, SULFATE ION | | 著者 | Darriba, M.L, Klinke, S, Otero, L.H, Cerutti, M.L, Cassataro, J, Pasquevich, K.A. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | A disordered region retains the full protease inhibitor activity and the capacity to induce CD8 + T cells in vivo of the oral vaccine adjuvant U-Omp19.
Comput Struct Biotechnol J, 20, 2022
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8QJQ
 | | SmNuc1 nuclease from Stenotrophomonas maltophilia in complex with cytidine - 5' - monophosphate as an inhibitor. | | 分子名称: | CYTIDINE-5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Adamkova, K, Koval, T, Kolenko, P, Dohnalek, J. | | 登録日 | 2023-09-13 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study.
Febs J., 2024
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5TPS
 | | Structure of a Fc heterodimer | | 分子名称: | Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Zhou, A, Wei, H. | | 登録日 | 2016-10-21 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A new Fc heterodimer
To be published
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7XV4
 | | Crystal structure of RPA70N-ATRIP fusion | | 分子名称: | ATR-interacting protein, Replication protein A 70 kDa DNA-binding subunit | | 著者 | Wu, Y.Y, Zang, N, Fu, W.M, Zhou, C. | | 登録日 | 2022-05-20 | | 公開日 | 2023-06-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023
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7UYX
 | | Structure of bacteriophage PA1c gp2 | | 分子名称: | Bacteriophage PA1C gp2 | | 著者 | Enustun, E, Deep, A, Gu, Y, Nguyen, K, Chaikeeratisak, V, Armbruster, E, Ghassemian, M, Pogliano, J, Corbett, K.D. | | 登録日 | 2022-05-07 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Identification of the bacteriophage nucleus protein interaction network.
Nat.Struct.Mol.Biol., 30, 2023
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8JSY
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8UC6
 | | Calpain-7:IST1 Complex | | 分子名称: | Calpain-7, IST1 homolog | | 著者 | Paine, E, Whitby, F.G, Hill, C.P, Sunquist, W.I. | | 登録日 | 2023-09-25 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission.
Elife, 12, 2023
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7UYZ
 | | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | | 分子名称: | Cyclic GMP-AMP synthase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | | 登録日 | 2022-05-07 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
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5CML
 | | Crystal structure of the Esterase domain from Rhodothermus marinus Rmar_1206 protein | | 分子名称: | OsmC family protein, TRIETHYLENE GLYCOL | | 著者 | Marles-Wright, J, Wardrope, C, Jensen, M.-B.V, Horsfall, L.E, Togneri, P.D, Rosser, S.J. | | 登録日 | 2015-07-16 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Characterisation of a New Family of Carboxyl Esterases with an OsmC Domain.
Plos One, 11, 2016
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8UM3
 | | PanDDA analysis -- Crystal Structure of Zika virus NS3 Helicase in complex with Z203039992 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 6-chlorotetrazolo[1,5-b]pyridazine, ... | | 著者 | Godoy, A.S, Noske, G.D, Fairhead, M, Lithgo, R.M, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Marples, P.G, Ni, X, Tomlinson, C.W.E, Wild, C, Mesquita, N.C.M.R, Oliva, G, Fearon, D, Walsh, M.A, von Delft, F. | | 登録日 | 2023-10-17 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (1.925 Å) | | 主引用文献 | PanDDA analysis -- Crystal Structure of Zika virus NS3 Helicase in complex with Z203039992
To Be Published
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7OQ1
 | | NaK S-ELM mutant with Na+ and K+ | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | | 著者 | Minniberger, S, Plested, A.J.R. | | 登録日 | 2021-06-02 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023
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7MHE
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957 | | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]benzene-1-sulfonyl}morpholine, Fatty acid synthase | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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7UZR
 | | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | | 分子名称: | Cyclic GMP-AMP synthase, MANGANESE (II) ION, Palindromic DNA18, ... | | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | | 登録日 | 2022-05-09 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS
Nat Commun, 15, 2024
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6MGF
 | | untagged, wild-type LptB in complex with ADP | | 分子名称: | (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-ben zopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Lipopolysaccharide export system ATP-binding protein LptB, ... | | 著者 | Mandler, M.D, Owens, T.W, Ruiz, N, Kahne, D. | | 登録日 | 2018-09-13 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.982 Å) | | 主引用文献 | Bypassing the requirement for coupling of ATP binding and hydrolysis in the lipopolysaccharide ABC transporte
not published
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8QW2
 | | Human NDPK-C in complex with UDP and Mg2+ | | 分子名称: | MAGNESIUM ION, Nucleoside diphosphate kinase 3, URIDINE-5'-DIPHOSPHATE | | 著者 | Werten, S, Amjadi, R, Scheffzek, K. | | 登録日 | 2023-10-18 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Mechanistic Insights into Substrate Recognition of Human Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes.
Int J Mol Sci, 25, 2024
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7OQ6
 | | Crystal structure of cytochrome P450 Sas16 from Streptomyces asterosporus | | 分子名称: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, THIOCYANATE ION | | 著者 | Zhang, L, Zhang, S, Bechthold, A, Einsle, O. | | 登録日 | 2021-06-02 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate.
Acta Pharm Sin B, 13, 2023
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7OR8
 | | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136 | | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | | 登録日 | 2021-06-04 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove
To Be Published
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8K9W
 | | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 4 (ADKI4) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lysine--tRNA ligase, ~{N}2-(2-methoxyphenyl)-~{N}4-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine | | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | | 登録日 | 2023-08-01 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
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7V0C
 | | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG | | 分子名称: | Cyclic GMP-AMP synthase, MANGANESE (II) ION, Palindromic DNA18, ... | | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | | 登録日 | 2022-05-10 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
To Be Published
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5GIB
 | | Succinic acid bound trypsin crystallized as dimer | | 分子名称: | CALCIUM ION, Cationic trypsin, SUCCINIC ACID | | 著者 | Kutumbarao, N.H.V, Manohar, R, KarthiK, L, Malathy, P, Gunasekaran, K, Velmurugan, D. | | 登録日 | 2016-06-22 | | 公開日 | 2016-08-10 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.697 Å) | | 主引用文献 | Trypsin bound with Succinic acid
To Be Published
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7V0R
 | | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA | | 分子名称: | Cyclic GMP-AMP synthase, MAGNESIUM ION, Palindromic DNA18, ... | | 著者 | Wu, S, Gabelli, S.B, Sohn, J. | | 登録日 | 2022-05-10 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA
To Be Published
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7ORT
 | | Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ176 | | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... | | 著者 | Centorrino, F, Wu, Q, Ottmann, C. | | 登録日 | 2021-06-06 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | A crystallography-based study of fragment extensions
into the 14-3-3 binding groove
To Be Published
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